I think Zack properly answered the question but just to cover all the bases:

CopyUpdate myTable set MyColumn = NULL

This would set the entire column to null as the Question Title asks.

To set a specific row on a specific column to null use:

CopyUpdate myTable set MyColumn = NULL where Field = Condition.

This would set a specific cell to null as the inner question asks.

Answer from Jeff Martin on Stack Overflow
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W3Schools
w3schools.com โ€บ sql โ€บ sql_null_values.asp
SQL NULL Values - IS NULL and IS NOT NULL
SELECT CustomerName, ContactName, Address FROM Customers WHERE Address IS NULL; Try it Yourself ยป ยท Tip: Always use IS NULL to look for NULL values. The IS NOT NULL operator is used to test for non-empty values (NOT NULL values).
Discussions

sql - Set default value in query when value is null - Stack Overflow
I'm running a really simple query, however for some of the results the value in one field is null. How can I set that value to "a string" if its value is null? Something like SELECT RegName, More on stackoverflow.com
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Assigning Null value to the variable โ€“ SQLServerCentral Forums
Assigning Null value to the variable Forum โ€“ Learn more on SQLServerCentral More on sqlservercentral.com
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August 25, 2008
SQL Query - Adding NULL results to a SELECT query - Stack Overflow
This is my first time using Stack Overflow, so I hope I'm asking this question in the right way. I have 2 SQL queries that I am trying to compare and identify the missing values, although I'm having More on stackoverflow.com
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February 7, 2012
Need some knowledge on NULL and NOT NULL
a null is used for multiple purposes -- for example, not known, not applicable, etc. theoreticians take great joy in debating which uses are valid, and whether they can be substituted by some non-null placeholder suffice to say, a null is used when you don't know what value should go there if you don't want that situation to arise, just make the column NOT NULL and you'll never be able to not insert an actual value More on reddit.com
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December 22, 2021
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GeeksforGeeks
geeksforgeeks.org โ€บ sql โ€บ how-to-set-a-column-value-to-null-in-sql
How to Set a Column Value to Null in SQL? - GeeksforGeeks
In this article 'How to Set a Column Value to Null in SQL', we have reached to some of the basic conclusions, that are listed below. Use the table name in the UPDATE statement. Put NULL in the column name. To select which rows to update, use ...
Published ย  July 23, 2025
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Scaler
scaler.com โ€บ home โ€บ topics โ€บ sql โ€บ null value in sql
NULL Value in SQL - Scaler Topics
March 28, 2024 - Suppose Vaibhav reaches out to the firm and tells them that he lost the SIM Card of his contact number. So please mark the Contact Number of Vaibhav as NULL. In the above scenario, we can use the assignment operator = to set Vaibhav's contact ...
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SQL Shack
sqlshack.com โ€บ working-with-sql-null-values
Working with SQL NULL values
May 19, 2021 - However, we can disable this behavior pattern by using the SET ANSI_NULLS command. By default, this option status is ON but we can disable this option during the session-level so the equals (=) and not equal (<>) comparison operators do not ...
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Tutorialspoint
tutorialspoint.com โ€บ sql โ€บ sql-null-values.htm
SQL - NULL Values
SELECT ID, NAME, AGE, ADDRESS, ... in SQL. To do so, you can use the IS NULL operator in your WHERE clause to filter the rows containing NULL values and then set the new value using the SET keyword....
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TutorialsPoint
tutorialspoint.com โ€บ article โ€บ how-to-set-a-column-value-to-null-in-sql
How to Set a Column Value to Null in SQL?
October 11, 2024 - The result of the above query would be as shown below ยท You can also set a column value to NULL without using the WHERE clause ? UPDATE Customers SET Gender = NULL; SELECT * FROM Customers;
Find elsewhere
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Wyzant
wyzant.com โ€บ resources โ€บ ask an expert
How do I set a column value to NULL in SQL Server Management Studio? | Wyzant Ask An Expert
May 10, 2019 - First the column should be null-able, you can right click, edit the table, select the column value you want to make null and press the CTRL + 0 buttons. After that click on any other column, if it is successfully updated, no message would be displayed, otherwise it would show you the error window.
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Devart
devart.com โ€บ home โ€บ how to โ€บ how to handle null or empty values in sql server
How to Handle Null or Empty Values in SQL Server
December 19, 2024 - The IS NULL operator in SQL Server checks whether a column or an expression contains a NULL value. The basic query syntax is as follows: SELECT column_names FROM table_name WHERE column_name IS NULL;
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GeeksforGeeks
geeksforgeeks.org โ€บ sql โ€บ sql-null-values
NULL values in SQL - GeeksforGeeks
January 5, 2026 - To do so, we can use the IS NULL operator in the WHERE clause to select the rows with NULL values and then we can set the new value using the SET keyword. Let's suppose that we want to update SSN in the row where it is NULL.
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GeeksforGeeks
geeksforgeeks.org โ€บ sql server โ€บ how-to-set-a-column-value-to-null-in-sql-server
How to Set a Column Value to NULL in SQL Server - GeeksforGeeks
July 23, 2025 - -- The Department is to be updated to null instead of the employee's EmployeeID 101 UPDATE EmployeeDetails SET Department = NULL WHERE EmployeeID = 101; -- Displaying updated data SELECT * FROM EmployeeDetails; ... Explanation: After executing ...
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TutorialsCampus
tutorialscampus.com โ€บ sql โ€บ select-null.htm
SQL Select Null
SELECT * FROM employee_details WHERE manager_id IS NOT NULL; By executing above query, we can get results as shown below - Scenario โ€“ Update rows which are having NULL values in a column.
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TutorialsTeacher
tutorialsteacher.com โ€บ sql โ€บ sql-null-value
SQL - NULL Value
To fetch the NULL values from a table, we can use keywords, NULL or NOT NULL. You can not select NULL data of a table by using any comparison operators (e.g. =, !=, >, < ).
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LearnSQL.com
learnsql.com โ€บ cookbook โ€บ how-to-select-null-values-in-sql
How to Select NULL Values in SQL | LearnSQL.com
To select rows with NULL in a given column, use a special operator IS NULL: SELECT EmployeeID, EmployeeName, Salary FROM Employees WHERE Salary IS NULL; ... NULL in SQL is used to indicate a missing or unknown value.
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Database Journal
databasejournal.com โ€บ home โ€บ features
Working with NULL Values in SQL | DatabaseJournal.com
March 9, 2023 - For instance, if we want to query data that contains NULL values, we can use the IS NULL or IS NOT NULL keywords. Letโ€™s say we want to select every employee from the employees table who do not have a phone number; in this instance, we would ...
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SQLServerCentral
sqlservercentral.com โ€บ forums โ€บ topic โ€บ assigning-null-value-to-the-variable
Assigning Null value to the variable โ€“ SQLServerCentral Forums
August 25, 2008 - Setting a variable to null is as simple as SET @VariableName = NULL ยท select @col1 = isnull(col1,NULL),@col2 = isnull(col2,null) from table ยท What are you trying to acheive here? ISNull is a function that returns the first value if the first value is not null and the second value if it is null.
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GeeksforGeeks
geeksforgeeks.org โ€บ sql โ€บ sql-select-null
SQL - SELECT NULL - GeeksforGeeks
July 23, 2025 - Handling NULL values in SQL is essential for accurate data querying and database integrity. Using conditions like IS NULL and IS NOT NULL, along with constraints such as NOT NULL, ensures that we can effectively manage missing data.
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DbSchema
dbschema.com โ€บ blog โ€บ tutorials โ€บ sql null values โ€“ is null, coalesce, nullif, and common pitfalls | dbschema
SQL NULL Values โ€“ IS NULL, COALESCE, NULLIF, and Common Pitfalls | DbSchema
August 22, 2023 - SELECT order_id, revenue / NULLIF(units_sold, 0) AS revenue_per_unit FROM sales; When units_sold is 0, NULLIF converts it to NULL, so the division returns NULL instead of an error.