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Mayo Clinic
mayoclinic.org › diseases-conditions › hashimotos-disease › diagnosis-treatment › drc-20351860
Hashimoto's disease-Hashimoto's disease - Diagnosis & treatment - Mayo Clinic
April 30, 2025 - If you're experiencing any of these symptoms, your health care provider will conduct a thorough physical exam, review your medical history and ask questions about your symptoms. To determine if hypothyroidism is the cause of your symptoms, your provider will order blood tests ...
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American Thyroid Association
thyroid.org › home › hashimoto’s thyroiditis
Hashimoto’s Thyroiditis | American Thyroid Association
August 25, 2023 - Hashimoto’s thyroiditis can be diagnosed even though you have no symptoms. Your thyroid antibody levels are high, but your thyroid hormone levels are normal. Repeating and monitoring your thyroid antibody levels is not needed. However, you do need to monitor your TSH blood level.
Discussions

Explain to me like I'm 5 how Hashimotos is diagnosed.
A couple of good comments already. Hashimotos is diagnosed based on the presence of antibodies which are attacking your thyroid. Now, depending how long that's been happening, your thyroid may or may not be still producing the necessary hormones. Which is why they also look at thyroid production levels (typically T4 is all they look at - lots of chatter in this subreddit about what numbers to look at). If your T4 is "in range," most docs won't want to touch anything until your thyroid starts to fail. HOWEVER, there is where TSH comes into play. If your TSH is high even with good T4, then how my doc explained it is your thyroid is working really, really hard to produce the hormones that it is. And typically, once the antibodies are discovered, there is no way of knowing how long it's been happening or how damaged your thyroid is, even if your other numbers are currently good. Now to confuse matters, your thyroid could fail for other, non Hashimotos reasons, as noted elsewhere in the thread. Hence, some people have hypothyroidism but not Hashi's, and vice versa if you have the antibodies but your thyroid is still functioning. Now to really complicate things (and where big arguments come into play) - immunomodulatory/immunosuppressant meds are pretty hard core and very powerful. They have serious side effects and can prevent the body from adequately responding to various factors and even worsen other autoimmune diseases. The "treatment" for Hashis is replacement thyroid hormones, which when at the right level etc, have basically no side effects. And taking those immunosuppressant meds won't restore thyroid function - you have antibodies, there is some unknown damage, and there is no way of "healing" your thyroid. The math is very much on the side of "take the tiny cheap replacement hormone." Research is mixed on what approach is any can slow the body's attack of the thyroid (lots of claims about various diets or other approaches), but things that are clear like other autoimmune diseases - high genetic component, monitor and watch, unknown what triggers (although typically some type of high stress/long illness correlates), once the body turns on itself, there's not much that can be done. Upside is that levo is basically bio-identical to what the body produces. My PCP put me on levo when my hormones where high, my TSH was high, but my T4 was perfect. I've had to adjust my diet a bit and add supplements, as Hashi's interferes with metabolism of certain nutrients. And I've had to change how I work out (I can't tolerate cardio or any high stress workouts - strength training, pilates, etc are all fine). And now I get maintenance blood draws. But it's not nearly as bad as the other autoimmune diseases floating around my family (we have great little cluster). Thus ends my TED talk. More on reddit.com
🌐 r/Hashimotos
57
28
November 18, 2024
What tests diagnosed you?
You only need a blood test for anti tpo and TSH. When your anti tpo levels are above 35 you have Hashimoto’s More on reddit.com
🌐 r/Hashimotos
46
9
September 1, 2023
Do you actually have a Hashimoto’s diagnosis?
Initially diagnosed with "being a woman", then diagnosed with "hormones, you'll be fine", then diagnosed with "Yes your thyroid levels aren't great but there's no need to medicate" and finally diagnosed with Hashimoto's after changing my GP to a female who would actually take me seriously More on reddit.com
🌐 r/Hashimotos
446
89
May 5, 2024
What symptoms led to your diagnosis?
Having two early miscarriages. Then started levothyroxine and now am 23 weeks pregnant with a healthy boy :) More on reddit.com
🌐 r/Hashimotos
95
12
January 25, 2024
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University of Michigan Health
uofmhealth.org › home › our care › specialties & services › hashimoto's disease
Hashimoto's Disease | University of Michigan Health
TSH is produced in the brain and travels to the thyroid gland to stimulate the thyroid to produce and release more thyroid hormone. A high TSH level indicates that the body does not have enough thyroid hormone. If the TSH level is found to be too high, other tests are usually ordered to further investigate the problem. Thyroid peroxidase antibodies and other anti-thyroid antibodies are also commonly tested for when confirming a diagnosis of Hashimoto's.
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NIDDK
niddk.nih.gov › home › health information › endocrine diseases › hashimoto's disease
Hashimoto's Disease - NIDDK
October 3, 2025 - Researchers don’t know why some people develop Hashimoto’s disease, but a family history of thyroid disease is common. Several factors may play a role, including2 · genes · viruses, such as hepatitis C · Hypothyroidism can also be caused by · some medicines used to treat bipolar disorder or other mental health problems · iodine-containing medicines used to treat abnormal heart rhythm · exposure to toxins, such as nuclear radiation · Doctors diagnose Hashimoto’s disease based on ·
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HealthDirect
healthdirect.gov.au › hashimotos-disease
Hashimoto's disease (Hashimoto's thyroiditis) | healthdirect
ASK YOUR DOCTOR — Preparing for an appointment? Use the Question Builder for general tips on what to ask your GP or specialist. While there is no cure for Hashimoto's disease, hypothyroidism can be treated.
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American Association of Clinical Endocrinology
aace.com › disease-and-conditions › thyroid › what-hashimotos-disease
What Is Hashimoto's Disease? | American Association of Clinical Endocrinology
Although many of the symptoms ... with Hashimoto’s disease who develop hypothyroidism are more likely to experience the following: ... A doctor can detect a goiter by performing a physical examination.
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Mayo Clinic
mayoclinic.org › diseases-conditions › hashimotos-disease › symptoms-causes › syc-20351855
Hashimoto's disease-Hashimoto's disease - Symptoms & causes - Mayo Clinic
April 30, 2025 - The thyroid gland is located at the base of the neck, just below the Adam's apple. ... Hashimoto's disease progresses slowly over the years. You may not notice signs or symptoms of the disease.
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Johns Hopkins Medicine
hopkinsmedicine.org › health › conditions-and-diseases › hashimotos-thyroiditis
Hashimoto's Thyroiditis | Johns Hopkins Medicine
August 8, 2024 - Hashimoto thyroiditis is the most common type of this health problem. It may also be called chronic autoimmune thyroiditis. This thyroiditis is an autoimmune disease. It occurs when your body makes antibodies that attack the cells in your thyroid. The thyroid gland becomes overrun with white blood cells and becomes scarred.
Find elsewhere
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HealthMatch
healthmatch.io › hashimotos-disease › hashimotos-thyroiditis-diagnosis-ultrasound
Diagnosing Hashimoto’s Thyroiditis: Ultrasound, Exams, And Blood Tests
June 1, 2022 - Hashimoto’s disease is a highly treatable condition. Find out how Hashimoto’s thyroiditis is diagnosed with ultrasound, exams, and blood tests.
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Penn Medicine
pennmedicine.org › home › conditions we treat › hashimotos disease
Hashimoto’s Disease – Symptoms and Causes | Penn Medicine
1 month ago - Diagnosing Hashimoto’s disease usually involves a physical exam and blood tests to check thyroid function. Your provider may order a thyroid-stimulating hormone (TSH) test and a free T4 (thyroxine) test. To see if hypothyroidism is linked to an autoimmune condition, they may also check for ...
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Better Health Channel
betterhealth.vic.gov.au › health › conditionsandtreatments › thyroid-hashimotos-disease
Thyroid - Hashimoto's disease | Better Health Channel
Myxoedema – this severe form of hypothyroidism produces symptoms and signs which may include unnatural sleepiness, extreme sensitivity to cool temperatures and coma. This condition may be fatal in severe cases. However, myxoedema is a very rare complication of untreated Hashimoto’s disease. Diagnosis of Hashimoto’s disease may include: Medical and family history ·
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Women's Health
womenshealth.gov › a-z-topics › hashimotos-disease
Hashimoto's disease | Office on Women's Health
Most of these women were recently diagnosed with hypothyroidism or had not yet started treatment for hypothyroidism.4 · Problems during pregnancy. The unborn baby's brain and nervous system need thyroid hormone to develop. Untreated or poorly treated Hashimoto's disease can lead to miscarriage, birth defects, or other problems. Hashimoto’s disease is treated with a daily dose of levothyroxine.
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Wikipedia
en.wikipedia.org › wiki › Hashimoto's_thyroiditis
Hashimoto's thyroiditis - Wikipedia
December 3, 2025 - Risk factors include a family history of the condition and having another autoimmune disease. Diagnosis is confirmed with blood tests for TSH, thyroxine (T4), antithyroid autoantibodies, and ultrasound.
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HealthCentral
healthcentral.com › condition › hashimotos-thyroiditis › hashimotos-thyroiditis-diagnosis
Hashimoto’s Thyroiditis Diagnosis
May 29, 2014 - Diagnosing Hashimoto’s thyroiditis may include physical examination, alongside testing. Learn how your doctor detects this common thyroid disorder.
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Anadolu Sağlık Merkezi
anadolumedicalcenter.com › health-guide › hashimoto-what-it-is-causes-symptoms-and-treatment
Hashimoto: What It Is, Causes, Symptoms, and Treatment | Anadolu Sağlık Merkezi
Damaged thyroid tissue is unable to synthesize enough hormones. As a result, the levels of thyroid hormone in the blood drop, leading to a condition called hypothyroidism, which causes various symptoms throughout the body. ... Hashimoto's disease is an autoimmune disorder.
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GoodRx
goodrx.com › goodrx health › health conditions › hypothyroidism: symptoms, causes, and treatments › hashimoto’s thyroiditis vs. hypothyroidism: what to know
Hashimoto’s Thyroiditis vs. Hypothyroidism: What to Know - GoodRx
August 9, 2024 - Sometimes, an ultrasound can help make the diagnosis of Hashimoto’s thyroiditis. The imaging may also include a fine-needle biopsy of thyroid tissue to confirm the diagnosis. This is often helpful when there’s a goiter or when thyroid lab tests are normal.
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Reddit
reddit.com › r/hashimotos › explain to me like i'm 5 how hashimotos is diagnosed.
r/Hashimotos on Reddit: Explain to me like I'm 5 how Hashimotos is diagnosed.
November 18, 2024 -

So I've been reading old posts to try to understand this but I'm still confused. I get that hypothyroidism and Hashimotos are related but don't always go hand in hand. One can be hypothyroid but not have Hashimotos and vice versa. But what I don't get is how Hashimotos is diagnosed if your thyroid levels are normal. And also, why don't doctors use medications like plaquenil to stop or slow autoimmune activity.

My husband has very high TPO antibodies but his T3, T4 and TSH are normal. His mom and brother are both hypothyroid,diagnosed with Hashimotos, and have been taking synthetic thyroid meds for a decade or more. My husband also has a 1:320 ANA. We are waiting to see a rheumatologist next month. He is experiencing a lot of fatigue.

His PCP shrugged off the thyroid antibodies and basically said nothing we can do until your thyroid fails. But that makes zero sense to me.

I have Sjogren’s and I take methotrexate, prescribed by my rheumatologist, to stop my body from attacking itself. Yes it comes with a small amount of risk but the reduction in inflammation and pain it gives me far outweighs this.

I really don't understand why the literature says the risks of immunomodulatory meds, like hydroxychloroquine, or immune suppressing meds are too great so they aren't prescribed for Hashimotos. This is completely contradictory to every other autoimmune disease.

Also, how is Hashimotos diagnosed if your thyroid is functioning still? What is the diagnosis criteria?

Lastly, is my husband's thyroid doomed to fail? Are we literally just supposed to sit on our hands and wait for that to happen?

He's already been dairy free for over 10 years. We eat very cleanly. My husband is very lean and athletic. He works out regularly. He takes a variety of supplements to support his health. What else can he do?

Sorry for the long vent with all the questions. We just feel helpless at this point and doctors aren't being much help.

Top answer
1 of 5
18
A couple of good comments already. Hashimotos is diagnosed based on the presence of antibodies which are attacking your thyroid. Now, depending how long that's been happening, your thyroid may or may not be still producing the necessary hormones. Which is why they also look at thyroid production levels (typically T4 is all they look at - lots of chatter in this subreddit about what numbers to look at). If your T4 is "in range," most docs won't want to touch anything until your thyroid starts to fail. HOWEVER, there is where TSH comes into play. If your TSH is high even with good T4, then how my doc explained it is your thyroid is working really, really hard to produce the hormones that it is. And typically, once the antibodies are discovered, there is no way of knowing how long it's been happening or how damaged your thyroid is, even if your other numbers are currently good. Now to confuse matters, your thyroid could fail for other, non Hashimotos reasons, as noted elsewhere in the thread. Hence, some people have hypothyroidism but not Hashi's, and vice versa if you have the antibodies but your thyroid is still functioning. Now to really complicate things (and where big arguments come into play) - immunomodulatory/immunosuppressant meds are pretty hard core and very powerful. They have serious side effects and can prevent the body from adequately responding to various factors and even worsen other autoimmune diseases. The "treatment" for Hashis is replacement thyroid hormones, which when at the right level etc, have basically no side effects. And taking those immunosuppressant meds won't restore thyroid function - you have antibodies, there is some unknown damage, and there is no way of "healing" your thyroid. The math is very much on the side of "take the tiny cheap replacement hormone." Research is mixed on what approach is any can slow the body's attack of the thyroid (lots of claims about various diets or other approaches), but things that are clear like other autoimmune diseases - high genetic component, monitor and watch, unknown what triggers (although typically some type of high stress/long illness correlates), once the body turns on itself, there's not much that can be done. Upside is that levo is basically bio-identical to what the body produces. My PCP put me on levo when my hormones where high, my TSH was high, but my T4 was perfect. I've had to adjust my diet a bit and add supplements, as Hashi's interferes with metabolism of certain nutrients. And I've had to change how I work out (I can't tolerate cardio or any high stress workouts - strength training, pilates, etc are all fine). And now I get maintenance blood draws. But it's not nearly as bad as the other autoimmune diseases floating around my family (we have great little cluster). Thus ends my TED talk.
2 of 5
9
There's this very very in depth resource on the specifics of Hashimoto's It goes into great detail about the progression of the disease and even the immune factors involved Unfortunately once the body is at the point of making antibodies that means it will "remember" this particular "enemy" Eventually their working on CRISPR based therapies or inverse vaccines but their still in research phases
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Verywell Health
verywellhealth.com › how-to-test-for-hashimotos-disease-4159884
Discover if You Have Hashimoto's With These Tests
October 23, 2025 - Hashimoto’s is typically diagnosed through a combination of your signs and symptoms, as well as blood tests. Your healthcare provider will review your health history, symptoms, and perform a physical exam to check for goiters.