March 23, 2023 - Secondary hypothyroidism is a rare form of hypothyroidism caused by your pituitary gland underproducing TSH. It makes up · less than 1% of cases of hypothyroidism and can cause symptoms like fatigue, poor cold tolerance, and weight gain.

Symptoms vary from mild to severe. The most severe form is called myxedema, which is a medical emergency and can lead to coma and death. Risk factors for secondary hypothyroidism include being over 50 years old, being female, and having a history of pituitary or hypothalamic dysfunction.

September 15, 2025 - Pituitary hypothyroidism occurs when the pituitary gland doesn't release enough TSH, leading to low thyroid hormone levels. Symptoms include fatigue, weight gain, constipation, and changes in skin, hair, and nails.

Symptoms of thyroid hormone insufficiency include cold intolerance, weight gain, memory loss, dry skin, hair loss, brittle nails, constipation, increased sleep demand, and fatigue. Severe hypothyroidism left untreated can lead to coma and even death. Hypothyroidism from TSH or TRH deficiency ...

December 10, 2022 - Understand what happens when your thyroid is underactive and learn about treatment for this condition.

January 17, 2023 - Symptoms of central hypothyroidism are similar to those of primary hypothyroidism (including fatigability, cold intolerance, weight gain, and depression), and may or may not be accompanied by symptoms of hypopituitarism, such as those of hypogonadism (i.e., decreased libido, infertility) and secondary adrenal insufficiency (i.e., weakness, nausea, vomiting).

May 15, 2021 - Clinical hypothyroidism occurs ... hypothyroidism can contribute to numerous physiologic and metabolic derangements. Signs and symptoms are nonspecific and can vary in individual presentations (Table 2 and Table 31,3,10). Diagnosis is based on blood levels of decreased FT4, with a corresponding elevated thyrotropin (i.e., TSH) level in primary causes (thyroid source); the TSH level may be normal to low in secondary (pituitary source) or ...

February 13, 2024 - Learn about the symptoms and treatment of this rare condition caused by a problem with the pituitary gland.

August 26, 2025 - UpToDate, the evidence-based clinical decision support resource from Wolters Kluwer, is trusted at the point of care by clinicians worldwide.

May 21, 2023 - While some risk factors may contribute ... pituitary disorders, iodine deficiencies, congenital disease, and pregnancy), hypothyroidism is most often caused by factors out of your control. [1] Instead, it’s more important to be aware of the signs of hypothyroidism and to see your doctor if you suspect any of your symptoms could be ...

February 18, 2024 - In primary hypothyroidism, the thyroid gland cannot produce adequate amounts of thyroid hormone. The less commonly seen secondary or central hypothyroidism occurs when the thyroid gland functions normally; however, hypothyroidism results from the abnormal pituitary gland or hypothalamus function.

February 13, 2024 - Learn about the symptoms and treatment of this rare condition caused by a problem with the pituitary gland.

Explore pituitary hypothyroidism, its causes, symptoms, and effective treatment options for better management.

October 16, 2025 - Secondary hypothyroidism happens when the pituitary gland does not make enough TSH to stimulate the thyroid, often due to a pituitary tumor. Symptoms include fatigue, dry skin, joint and muscle pain, and weight gain.

August 28, 2023 - If a patient has hypothyroidism, they may experience symptoms such as weight gain, fatigue, cold intolerance, constipation, dry skin, and irregular menses in females.[8] Children may present with delayed growth, short stature, obesity, and rarely precocious puberty.[9] Since a TSH-producing ...

June 2, 2025 - For the most part, the symptoms of thyroid disease can be divided into two groups — those related to having too much thyroid hormone (hyperthyroidism) and those related to having too little thyroid hormone (hypothyroidism). The symptoms are often “opposites” between the two conditions.

March 23, 2025 - Central hypothyroidism should be treated with thyroid hormone replacement therapy, and the diagnosis should involve evaluating TSH and FT4 levels, with low T...

December 21, 2023 - In other words, the problem isn’t the thyroid gland itself, but the pituitary gland or hypothalamus. Common symptoms of central hypothyroidism include fatigue, hair loss, and ...

August 13, 2025 - In infants and children, central hypothyroidism may be caused by gene mutations or other issues such as2: craniopharyngiomas (benign tumors of the pituitary gland) ... Other symptoms may include low sodium, high cholesterol, heart failure, and QT interval prolongation.

July 10, 2017 - Hypothyroidism due to pituitary problems (central hypothyroidism) is associated with normal or low TSH levels in the setting of low thyroid hormone levels. The most common pituitary problems to cause central hypothyroidism are tumors of the pituitary gland. Treatment of hypothyroidism in these patients is complex because the TSH level cannot be used to help determine the correct dose.