argparse supports nargs parameter, which tells you how many parameters it eats. When nargs="+" it accepts one or more parameters, so you can pass -b 1 2 3 4 and it will be assigned as a list to b argument

# args.py
import argparse

p = argparse.ArgumentParser()

# accept two lists of arguments
# like -a 1 2 3 4 -b 1 2 3
p.add_argument('-a', nargs="+", type=int)
p.add_argument('-b', nargs="+", type=int)
args = p.parse_args()

# check if input is valid
set_a = set(args.a)
set_b = set(args.b)

# check if "a" is in proper range.
if len(set_a - set(range(1, 51))) > 0: # can use also min(a)>=1 and max(a)<=50
    raise Exception("set a not in range [1,50]")

# check if "b" is in "a"
if len(set_b - set_a) > 0:
    raise Exception("set b not entirely in set a")

# you could even skip len(...) and leave just operations on sets
# ...

So you can run:

$ python arg.py  -a 1 2 3 4 -b 2 20
Exception: set b not entirely in set a

$ python arg.py  -a 1 2 3 4 60 -b 2
Exception: set a not in range [1,50]

And this is valid:

$ python arg.py  -a 1 2 3 4 -b 2 3

With argparse, you just use type=int

import argparse

parser = argparse.ArgumentParser()
parser.add_argument('-a', '--arg', nargs='+', type=int)
print parser.parse_args()

Example output:

$ python test.py -a 1 2 3
Namespace(arg=[1, 2, 3])

Edit: I'm not familiar with argh, but it seems to be just a wrapper around argparse and this worked for me:

import argh

@argh.arg('-a', '--arg', nargs='+', type=int)
def main(args):
    print args

parser = argh.ArghParser()
parser.add_commands([main])
parser.dispatch()

Example output:

$ python test.py main -a 1 2 3
Namespace(arg=[1, 2, 3], function=<function main at 0x.......>)

SHORT ANSWER

Use the nargs option or the 'append' setting of the action option (depending on how you want the user interface to behave).

nargs

parser.add_argument('-l','--list', nargs='+', help='<Required> Set flag', required=True)
# Use like:
# python arg.py -l 1234 2345 3456 4567

nargs='+' takes 1 or more arguments, nargs='*' takes zero or more.

append

parser.add_argument('-l','--list', action='append', help='<Required> Set flag', required=True)
# Use like:
# python arg.py -l 1234 -l 2345 -l 3456 -l 4567

With append you provide the option multiple times to build up the list.

Don't use type=list!!! - There is probably no situation where you would want to use type=list with argparse. Ever.

LONG ANSWER

Let's take a look in more detail at some of the different ways one might try to do this, and the end result.

import argparse

parser = argparse.ArgumentParser()

# By default it will fail with multiple arguments.
parser.add_argument('--default')

# Telling the type to be a list will also fail for multiple arguments,
# but give incorrect results for a single argument.
parser.add_argument('--list-type', type=list)

# This will allow you to provide multiple arguments, but you will get
# a list of lists which is not desired.
parser.add_argument('--list-type-nargs', type=list, nargs='+')

# This is the correct way to handle accepting multiple arguments.
# '+' == 1 or more.
# '*' == 0 or more.
# '?' == 0 or 1.
# An int is an explicit number of arguments to accept.
parser.add_argument('--nargs', nargs='+')

# To make the input integers
parser.add_argument('--nargs-int-type', nargs='+', type=int)

# An alternate way to accept multiple inputs, but you must
# provide the flag once per input. Of course, you can use
# type=int here if you want.
parser.add_argument('--append-action', action='append')

# To show the results of the given option to screen.
for _, value in parser.parse_args()._get_kwargs():
    if value is not None:
        print(value)

Here is the output you can expect:

$ python arg.py --default 1234 2345 3456 4567
...
arg.py: error: unrecognized arguments: 2345 3456 4567

$ python arg.py --list-type 1234 2345 3456 4567
...
arg.py: error: unrecognized arguments: 2345 3456 4567

$ # Quotes won't help here... 
$ python arg.py --list-type "1234 2345 3456 4567"
['1', '2', '3', '4', ' ', '2', '3', '4', '5', ' ', '3', '4', '5', '6', ' ', '4', '5', '6', '7']

$ python arg.py --list-type-nargs 1234 2345 3456 4567
[['1', '2', '3', '4'], ['2', '3', '4', '5'], ['3', '4', '5', '6'], ['4', '5', '6', '7']]

$ python arg.py --nargs 1234 2345 3456 4567
['1234', '2345', '3456', '4567']

$ python arg.py --nargs-int-type 1234 2345 3456 4567
[1234, 2345, 3456, 4567]

$ # Negative numbers are handled perfectly fine out of the box.
$ python arg.py --nargs-int-type -1234 2345 -3456 4567
[-1234, 2345, -3456, 4567]

$ python arg.py --append-action 1234 --append-action 2345 --append-action 3456 --append-action 4567
['1234', '2345', '3456', '4567']

Takeaways:

• Use nargs or action='append'
  • nargs can be more straightforward from a user perspective, but it can be unintuitive if there are positional arguments because argparse can't tell what should be a positional argument and what belongs to the nargs; if you have positional arguments then action='append' may end up being a better choice.
  • The above is only true if nargs is given '*', '+', or '?'. If you provide an integer number (such as 4) then there will be no problem mixing options with nargs and positional arguments because argparse will know exactly how many values to expect for the option.
• Don't use quotes on the command line¹
• Don't use type=list, as it will return a list of lists
  • This happens because under the hood argparse uses the value of type to coerce each individual given argument you your chosen type, not the aggregate of all arguments.
  • You can use type=int (or whatever) to get a list of ints (or whatever)

¹: I don't mean in general.. I mean using quotes to pass a list to argparse is not what you want.

Remove the nargs=1 part.
From: https://docs.python.org/3/library/argparse.html#nargs

Note that nargs=1 produces a list of one item. This is different from the default, in which the item is produced by itself.