You can intercept the ctrl+c signal and call your own function at that time rather than exiting.

import signal
import sys

def exit_func(signal, frame):
    '''Exit function to be called when the user presses ctrl+c.
    Replace this with whatever you want to do to break out of the loop.
    '''
    print("Exiting")
    sys.exit(0) # remove this if you do not want to exit here

# register your exit function to handle the ctrl+c signal
signal.signal(signal.SIGINT, exit_func)

#loop forever
while True:
    ...

You should replace sys.exit(0) with something more useful to you. You could raise an exception and that except on it outside the loop body (or just finally) to perform your cleanup actions.

Because your program uses the tkinter module, binding is very easy. You don't need any external modules like PyHook.

For example:

from tkinter import * #imports everything from the tkinter library

def confirm(event=None): #set event to None to take the key argument from .bind
    print('Function successfully called!') #this will output in the shell

master = Tk() #creates our window

option1 = Button(master, text = 'Press Return', command = confirm)
option1.pack() #the past 2 lines define our button and make it visible

master.bind('<Return>', confirm) #binds 'return' to the confirm function

Unfortunately, this will only work in a Tk() window. Also, when applying the callback during the key binding, you can't specify any arguments.

As a further explanation of event=None, we put it in because master.bind annoyingly sends the key as an argument. This is is fixed by putting event as the parameter in the function. We then set event to the default value None because we have a button that uses the same callback, and if it wasn't there we would get a TypeError.

Python has a keyboard module with many features. Install it, perhaps with this command:

pip3 install keyboard

Then use it in code like:

import keyboard  # using module keyboard
while True:  # making a loop
    try:  # used try so that if user pressed other than the given key error will not be shown
        if keyboard.is_pressed('q'):  # if key 'q' is pressed 
            print('You Pressed A Key!')
            break  # finishing the loop
    except:
        break  # if user pressed a key other than the given key the loop will break