February 15, 2024 - Pearce SH, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, Wemeau JL. 2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J. 2013 Dec;2(4):215-28.

September 1, 2020 - Treatment of subclinical hypothyroidism has long been controversial because of normal increases in TSH with age, variability between TSH measurements, and concerns for harm from treatment. Previous guidelines suggested that levothyroxine treatment may be appropriate with hypothyroid symptoms or a TSH level exceeding 10 mIU per L based on limited evidence.

March 15, 2021 - Importantly, there was no evidence that treating increased the risk of death in any age group. Current American Thyroid Association guidelines recommend treating subclinical hypothyroidism only if the TSH is above 10, regardless of age.

Subclinical hypothyroidism (SCH) is diagnosed when serum thyroid stimulation hormone (thyrotropin; TSH) levels are above the reference range, accompanied by levels of free thyroxine within its reference range. The management of SCH remains a diagnostic and therapeutic challenge despite many years of research relating to its epidemiology, aetiology, effectiveness of treatment and safety. European Thyroid Association (ETA) guidelines for the management of SCH were published almost a decade ago.

November 1, 2012 - Hypothyroidism may be either subclinical or overt. Subclinical hypothyroidism is characterized by a serum TSH above the upper reference limit in combination with a normal free thyroxine (T4).

May 1, 2024 - Patient perspective and feedback were elicited during the review and before the publication of this guideline. Subclinical hypothyroidism is diagnosed as a TSH concentration above the upper limit of the normal range and a serumfree thyroxine (T4) concentration within the normal range.

May 14, 2019 - Clinical question What are the benefits and harms of thyroid hormones for adults with subclinical hypothyroidism (SCH)? This guideline was triggered by a recent systematic review of randomised controlled trials, which could alter practice.

January 14, 2004 - Context Patients with serum thyroid-stimulating hormone (TSH) levels outside the reference range and levels of free thyroxine (FT4) and triiodothyronine (T3) within the reference range are common in clinical practice. The necessity for further evaluation, possible treatment, and the urgency of...

December 1, 2013 - Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation in serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0-10.0 mU/l) and more severely increased TSH value (>10 mU/l).

The management of subclinical primary hypothyroidism in non-pregnant adults.

February 1, 2019 - Natural course of subclinical hypothyroidism (TSH = thyroid-stimulating hormone, T4 = free thyroxine). Guidelines differ on screening for thyroid disease in the general population, owing to lack of large-scale randomized controlled trials showing treatment benefit in otherwise-healthy people ...

February 15, 1998 - Indications for treatment in subclinical hypothyroidism are not established, but general guidelines can be offered.

Recent studies have shown that levothyroxine treatment in milder forms rarely affects cognition, weight, or quality of life. Lifelong medication with levothyroxine should normally only be considered in manifest hypothyroidism. In subclinical hypothyroidism with TSH >10 mIU/L, treatment is indicated.

April 1, 2025 - The European Thyroid Association, in its 2013 guideline,10 recommends classifying subclinical hypothyroidism as mild or severe according to TSH level; if mild, it suggests no treatment but repeating this measurement 2 to 3 months later, along ...

Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation in serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0-10.0 mU/l) and more severely increased TSH value (>10 mU/l). An ...

A normal TSH reference range should ... of Subclinical Hypothyroidism, which set the TSH threshold at 4.0 mIU/L and classified TSH levels between 4.0 and 10.0 mIU/L as mildly increased and levels above 10 as severely increased [5]....

July 8, 2025 - Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid. 2014;24(12):1670–1751. doi:10.1089/thy.2014.0028 · Hennessey JV, Espaillat R. Diagnosis and management of subclinical hypothyroidism in elderly ...

August 8, 2023 - Keypoint The 2023 Korean Thyroid Association guidelines offer an updated approach to subclinical hypothyroidism management. They present new diagnostic criteria, region-specific thyroid-stimulating hormone reference ranges, and classify subclinical hypothyroidism severity based on age.

May 15, 2021 - Most patients with subclinical hypothyroidism do not benefit from treatment unless the thyroid-stimulating hormone level is greater than 10 mIU per L or the thyroid peroxidase antibody is elevated.