Suppose you have a 1D array, you plot the position of its values on the x axis, they are so dense that you can't tell the spatial distribution, you use a 1D histogram to show the distribution by count of boxes along the x axis. Problem solved.
Then you have two 1D arrays, a list of 2D dots in (x, y) axes. You plot their positions on the x-y plane, again they are so dense and overlap with each other. You want to view the distribution better by count of boxes in the plane, so you try a 2D diagram. Problem solved.
Here is an example
import numpy as np
import matplotlib.pyplot as plt
%matplotlib inline
# prepare 2D random dots centered at (0, 0)
n = 100000
x = np.random.randn(n)
y = x + np.random.randn(n)
# plot data
fig1 = plt.figure()
plt.plot(x,y,'.r')
plt.xlabel('x')
plt.ylabel('y')
gives

# plot 2D histogram using pcolor
fig2 = plt.figure()
plt.hist2d(x, y, bins=100)
plt.xlabel('x')
plt.ylabel('y')
cbar = plt.colorbar()
cbar.ax.set_ylabel('Counts')
gives

If you have the raw data from the counts, you could use plt.hexbin to create the plots for you (IMHO this is better than a square lattice): Adapted from the example of hexbin:
import numpy as np
import matplotlib.pyplot as plt
n = 100000
x = np.random.standard_normal(n)
y = 2.0 + 3.0 * x + 4.0 * np.random.standard_normal(n)
plt.hexbin(x,y)
plt.show()

If you already have the Z-values in a matrix as you mention, just use plt.imshow or plt.matshow:
XB = np.linspace(-1,1,20)
YB = np.linspace(-1,1,20)
X,Y = np.meshgrid(XB,YB)
Z = np.exp(-(X**2+Y**2))
plt.imshow(Z,interpolation='none')

If you have not only the 2D histogram matrix but also the underlying (x, y) data, then you could make a scatter plot of the (x, y) points and color each point according to its binned count value in the 2D-histogram matrix:
import numpy as np
import matplotlib.pyplot as plt
n = 10000
x = np.random.standard_normal(n)
y = 2.0 + 3.0 * x + 4.0 * np.random.standard_normal(n)
xedges, yedges = np.linspace(-4, 4, 42), np.linspace(-25, 25, 42)
hist, xedges, yedges = np.histogram2d(x, y, (xedges, yedges))
xidx = np.clip(np.digitize(x, xedges), 0, hist.shape[0]-1)
yidx = np.clip(np.digitize(y, yedges), 0, hist.shape[1]-1)
c = hist[xidx, yidx]
plt.scatter(x, y, c=c)
plt.show()
