April 9, 2025 - For patients seeking improved quality of life, these advancements are a game-changer in managing Hashimoto's Thyroiditis. ... New Potential Treatments: Metformin, DTE or LT4/T3 combination therapy, and surgical interventions are among the emerging treatments. Clinical Trials: Ongoing research and ...

March 2, 2025 - Here, we designed and synthesized a near-infrared fluorescent probe named HNTC-HT for differentiated imaging of Hashimoto's thyroiditis against thyroid carcinoma. Reactive oxygen species (ROS), such as peroxynitrite (ONOO−), highly accumulated ...

40.Zeber-Lubecka N., Kulecka M., Suchta K., Dąbrowska M., Ciebiera M., Hennig E.E. Association of Mitochondrial Variants with the Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis. Antioxidants. 2023;12:1983. doi: 10.3390/antiox12111983.

November 9, 2025 - The latest research on Hashimoto’s thyroiditis suggests that the treatment with mesenchymal stem cells can help regenerate the damaged tissues of the thyroid and improve the functions of this gland.

November 30, 2025 - ... Recent systematic reviews and meta-analyses showed modest benefits in managing Hashimoto thyroiditis in individuals without thyroid hormone replacement, with improved thyroid function parameters and reduced thyroid antibodies.[25][96] More research is needed to establish clear benefits.

May 5, 2021 - The increased but non-predominant expression of Th17- and Th1-specific cytokines in Hashimoto’s thyroiditis but not in Graves’ disease. Braz. J. Med. Biol. Res. 45, 1202–1208. doi: 10.1590/s0100-879x2012007500168 · PubMed Abstract | CrossRef Full Text | Google Scholar · Rajaei, E., Haybar, H., Mowla, K., and Zayeri, Z. D. (2019). Metformin one in a million efficient medicines for rheumatoid arthritis complications: inflammation, osteoblastogenesis, cardiovascular disease, malignancies.

April 11, 2025 - Nevertheless, careful consideration of sample size and strategies to address overfitting are essential to optimize their effectiveness in medical research contexts. To our knowledge, this is the first study to report circulating levels of a comprehensive panel of organic and fatty acids in patients with Hashimoto’s thyroiditis.

August 25, 2023 - April 21, 2021 in Clinical ... Thyroidology®, and VideoEndocrinology™ Latest Impact Factor: 5.309 Special Collection in Recognition of Hashimoto's Thyroiditis…...

December 17, 2020 - Eventually Rose purified thyroglobulin which was injected back into the very same animal from which it was derived and found not only antibodies but also inflammation in the thyroid: he had discovered autoimmune thyroiditis [1]. This seminal discovery prompted Doniach and Roitt to become the first to detect thyroglobulin antibodies in the sera of patients with Hashimoto’s thyroiditis (HT), the cause of which they had been trying to elucidate [2].

September 4, 2024 - Since there’s previous evidence ... AI · In 2022, with the help of AI, investigators published the first complete model of the thyroid-stimulating hormone (TSH) receptor. Visualizing the receptor for TSH has been incredibly useful for researchers and has already led to a couple of new discoveries. To the biologists’ surprise in 2023, a newfound region on the TSH receptor allows water entry and exit...

This could help titrating thyroid hormone replacement therapy. New preparations of sustained release T3 have successfully passed phase 1 clinical trials and may add to our armamentarium for HT therapy once necessary efficacy trials are completed. CONFLICT OF INTEREST None declared. 1.Hashimoto H The knowledge of the lymphomatous changes in the thyroid gland (struma lymphomatosa) [in German]. Archiv für klinische Chirurgie.

August 15, 2020 - Although the exact etiology has not been fully elucidated, Hashimoto's thyroiditis is related to an interaction among genetic elements, environmental factors and epigenetic influences. Cellular and humoral immunity play a key role in the development of the disease; thus, a T and B cells inflammatory infiltration is frequently found.

Studies in animals have shown that ... latest research on the pathogenesis of Hashimoto’s thyroiditis, the influence of MIF on antibodies occurring over the course of the disease has also been demonstrated....

December 3, 2025 - From this data, it was proposed that Hashimoto's struma could be an autoimmune disease of the thyroid gland: "Following these discoveries, the concept of organ-specific autoimmune disease was established and HT recognized as one such disease." Following this recognition, the same researchers from Middlesex Hospital published an article in 1962 in The Lancet that included a portrait of Hakaru Hashimoto.

Physical findings are variable and depend on the extent of the hypothyroidism and other factors, such as age. Examination findings may include the following: Puffy face and periorbital edema typical of hypothyroid facies ... Laboratory studies and potential results for patients with suspected Hashimoto thyroiditis include the following:

September 8, 2025 - Over time, the damage can prevent your thyroid from making enough thyroid hormone that your body needs. This leads to hypothyroidism. However, not everyone with Hashimoto’s disease develops hypothyroidism. Factors that may increase your risk of developing Hashimoto’s disease include your: Family history: Research suggests that your genetics account for about 80% of your likelihood of developing Hashimoto’s.

April 30, 2025 - What causes the immune system to attack thyroid cells is not clear. The onset of disease may be related to: ... Sex. Women are much more likely to get Hashimoto's disease.

September 29, 2022 - Methods: For this systematic review and meta-analysis, we searched PubMed, Embase, MEDLINE, Scopus, and Web of Science databases, and 48 random-effects representative studies from the inception to June 2022 were included without language restrictions to obtain the overall prevalence of Hashimoto's thyroiditis in adults worldwide. In addition, we stratified by time of publication, geographic region, economic level of the region of residence, gender, diagnostic method, etc. Results: A total of 11,399 studies were retrieved, of which 48 met the research criteria: 20 from Europe, 16 from Asia, five from South America, three from North America, and three from Africa.

August 8, 2024 - It will also depend on how severe the condition is. You will not need treatment if your thyroid hormone levels are normal. But Hashimoto thyroiditis can cause an underactive thyroid gland. If so, it can be treated with medicine. The medicine replaces lost thyroid hormone.

January 18, 2022 - This article is part of the Research TopicEnvironmental Exposures and Thyroid HealthView all 11 articles · Jiangyue Xu1†Ke Ding2†Lan Mu1Jiangsheng Huang1Fei Ye1Yu Peng1Can Guo1Chutong Ren1* 1Department of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, China · 2Department of Urology, Xiangya Hospital, Central South University, Changsha, China · Background: The prevalence of thyroid carcinoma (TC) and Hashimoto’s thyroiditis (HT) has been increasing dramatically over the past decades.