Generally your idea of trying to apply astype to each column is fine.

In [590]: X[:,0].astype(int)
Out[590]: array([1, 2, 3, 4, 5])

But you have to collect the results in a separate list. You can't just put them back in X. That list can then be concatenated.

In [601]: numlist=[]; obj_ind=[]

In [602]: for ind in range(X.shape[1]):
   .....:     try:
   .....:         x = X[:,ind].astype(np.float32)
   .....:         numlist.append(x)
   .....:     except:
   .....:         obj_ind.append(ind)

In [603]: numlist
Out[603]: [array([ 3.,  4.,  5.,  6.,  7.], dtype=float32)]

In [604]: np.column_stack(numlist)
Out[604]: 
array([[ 3.],
       [ 4.],
       [ 5.],
       [ 6.],
       [ 7.]], dtype=float32)

In [606]: obj_ind
Out[606]: [1]

X is a numpy array with dtype object:

In [582]: X
Out[582]: 
array([[1, 'A'],
       [2, 'A'],
       [3, 'C'],
       [4, 'D'],
       [5, 'B']], dtype=object)

You could use the same conversion logic to create a structured array with a mix of int and object fields.

In [616]: ytype=[]

In [617]: for ind in range(X.shape[1]):
    try:                        
        x = X[:,ind].astype(np.float32)
        ytype.append('i4')
    except:
        ytype.append('O')       

In [618]: ytype
Out[618]: ['i4', 'O']

In [620]: Y=np.zeros(X.shape[0],dtype=','.join(ytype))

In [621]: for i in range(X.shape[1]):
    Y[Y.dtype.names[i]] = X[:,i]

In [622]: Y
Out[622]: 
array([(3, 'A'), (4, 'A'), (5, 'C'), (6, 'D'), (7, 'B')], 
      dtype=[('f0', '<i4'), ('f1', 'O')])

Y['f0'] gives the the numeric field.

Use val.item() to convert most NumPy values to a native Python type:

import numpy as np

# for example, numpy.float32 -> python float
val = np.float32(0)
pyval = val.item()
print(type(pyval))         # <class 'float'>

# and similar...
type(np.float64(0).item()) # <class 'float'>
type(np.uint32(0).item())  # <class 'int'>
type(np.int16(0).item())   # <class 'int'>
type(np.cfloat(0).item())  # <class 'complex'>
type(np.datetime64(0, 'D').item())  # <class 'datetime.date'>
type(np.datetime64('2001-01-01 00:00:00').item())  # <class 'datetime.datetime'>
type(np.timedelta64(0, 'D').item()) # <class 'datetime.timedelta'>
...

(A related method np.asscalar(val) was deprecated with 1.16, and removed with 1.23).

For the curious, to build a table of conversions of NumPy array scalars for your system:

for name in dir(np):
    obj = getattr(np, name)
    if hasattr(obj, 'dtype'):
        try:
            if 'time' in name:
                npn = obj(0, 'D')
            else:
                npn = obj(0)
            nat = npn.item()
            print('{0} ({1!r}) -> {2}'.format(name, npn.dtype.char, type(nat)))
        except:
            pass

There are a few NumPy types that have no native Python equivalent on some systems, including: clongdouble, clongfloat, complex192, complex256, float128, longcomplex, longdouble and longfloat. These need to be converted to their nearest NumPy equivalent before using .item().

Your second method is to be preferred, but using np.float32 means casting numbers to single precision. For your matrix, this precision is too low: 115.80200375 becomes 115.80200195 due to truncation. You can set double precition explicitly with numpy.float64, or just pass Python's float type as an argument, which means the same.

Z = numpy.array(matr.tolist(), dtype=float)

or, to keep the matrix structure,

Z = numpy.matrix(matr.tolist(), dtype=float)