You can convert most of the columns by just calling convert_objects:

CopyIn [36]:

df = df.convert_objects(convert_numeric=True)
df.dtypes
Out[36]:
Date         object
WD            int64
Manpower    float64
2nd          object
CTR          object
2ndU        float64
T1            int64
T2          int64
T3           int64
T4        float64
dtype: object

For column '2nd' and 'CTR' we can call the vectorised str methods to replace the thousands separator and remove the '%' sign and then astype to convert:

CopyIn [39]:

df['2nd'] = df['2nd'].str.replace(',','').astype(int)
df['CTR'] = df['CTR'].str.replace('%','').astype(np.float64)
df.dtypes
Out[39]:
Date         object
WD            int64
Manpower    float64
2nd           int32
CTR         float64
2ndU        float64
T1            int64
T2            int64
T3            int64
T4           object
dtype: object
In [40]:

df.head()
Out[40]:
        Date  WD  Manpower   2nd   CTR  2ndU   T1  　　T2   T3     T4
0   2013/4/6   6       NaN  2645  5.27  0.29  407   533  454    368
1   2013/4/7   7       NaN  2118  5.89  0.31  257   659  583    369
2  2013/4/13   6       NaN  2470  5.38  0.29  354   531  473  　　383
3  2013/4/14   7       NaN  2033  6.77  0.37  396   748  681    458
4  2013/4/20   6       NaN  2690  5.38  0.29  361   528  541    381

Or you can do the string handling operations above without the call to astype and then call convert_objects to convert everything in one go.

UPDATE

Since version 0.17.0 convert_objects is deprecated and there isn't a top-level function to do this so you need to do:

df.apply(lambda col:pd.to_numeric(col, errors='coerce'))

See the docs and this related question: pandas: to_numeric for multiple columns

You have four main options for converting types in pandas:

1. to_numeric() - provides functionality to safely convert non-numeric types (e.g. strings) to a suitable numeric type. (See also to_datetime() and to_timedelta().)

2. astype() - convert (almost) any type to (almost) any other type (even if it's not necessarily sensible to do so). Also allows you to convert to categorial types (very useful).

3. infer_objects() - a utility method to convert object columns holding Python objects to a pandas type if possible.

4. convert_dtypes() - convert DataFrame columns to the "best possible" dtype that supports pd.NA (pandas' object to indicate a missing value).

Read on for more detailed explanations and usage of each of these methods.

1. to_numeric()

The best way to convert one or more columns of a DataFrame to numeric values is to use pandas.to_numeric().

This function will try to change non-numeric objects (such as strings) into integers or floating-point numbers as appropriate.

Basic usage

The input to to_numeric() is a Series or a single column of a DataFrame.

>>> s = pd.Series(["8", 6, "7.5", 3, "0.9"]) # mixed string and numeric values
>>> s
0      8
1      6
2    7.5
3      3
4    0.9
dtype: object

>>> pd.to_numeric(s) # convert everything to float values
0    8.0
1    6.0
2    7.5
3    3.0
4    0.9
dtype: float64

As you can see, a new Series is returned. Remember to assign this output to a variable or column name to continue using it:

# convert Series
my_series = pd.to_numeric(my_series)

# convert column "a" of a DataFrame
df["a"] = pd.to_numeric(df["a"])

You can also use it to convert multiple columns of a DataFrame via the apply() method:

# convert all columns of DataFrame
df = df.apply(pd.to_numeric) # convert all columns of DataFrame

# convert just columns "a" and "b"
df[["a", "b"]] = df[["a", "b"]].apply(pd.to_numeric)

As long as your values can all be converted, that's probably all you need.

Error handling

But what if some values can't be converted to a numeric type?

to_numeric() also takes an errors keyword argument that allows you to force non-numeric values to be NaN, or simply ignore columns containing these values.

Here's an example using a Series of strings s which has the object dtype:

>>> s = pd.Series(['1', '2', '4.7', 'pandas', '10'])
>>> s
0         1
1         2
2       4.7
3    pandas
4        10
dtype: object

The default behaviour is to raise if it can't convert a value. In this case, it can't cope with the string 'pandas':

>>> pd.to_numeric(s) # or pd.to_numeric(s, errors='raise')
ValueError: Unable to parse string

Rather than fail, we might want 'pandas' to be considered a missing/bad numeric value. We can coerce invalid values to NaN as follows using the errors keyword argument:

>>> pd.to_numeric(s, errors='coerce')
0     1.0
1     2.0
2     4.7
3     NaN
4    10.0
dtype: float64

The third option for errors is just to ignore the operation if an invalid value is encountered:

>>> pd.to_numeric(s, errors='ignore')
# the original Series is returned untouched

This last option is particularly useful for converting your entire DataFrame, but don't know which of our columns can be converted reliably to a numeric type. In that case, just write:

df.apply(pd.to_numeric, errors='ignore')

The function will be applied to each column of the DataFrame. Columns that can be converted to a numeric type will be converted, while columns that cannot (e.g. they contain non-digit strings or dates) will be left alone.

Downcasting

By default, conversion with to_numeric() will give you either an int64 or float64 dtype (or whatever integer width is native to your platform).

That's usually what you want, but what if you wanted to save some memory and use a more compact dtype, like float32, or int8?

to_numeric() gives you the option to downcast to either 'integer', 'signed', 'unsigned', 'float'. Here's an example for a simple series s of integer type:

>>> s = pd.Series([1, 2, -7])
>>> s
0    1
1    2
2   -7
dtype: int64

Downcasting to 'integer' uses the smallest possible integer that can hold the values:

>>> pd.to_numeric(s, downcast='integer')
0    1
1    2
2   -7
dtype: int8

Downcasting to 'float' similarly picks a smaller than normal floating type:

>>> pd.to_numeric(s, downcast='float')
0    1.0
1    2.0
2   -7.0
dtype: float32

2. astype()

The astype() method enables you to be explicit about the dtype you want your DataFrame or Series to have. It's very versatile in that you can try and go from one type to any other.

Basic usage

Just pick a type: you can use a NumPy dtype (e.g. np.int16), some Python types (e.g. bool), or pandas-specific types (like the categorical dtype).

Call the method on the object you want to convert and astype() will try and convert it for you:

# convert all DataFrame columns to the int64 dtype
df = df.astype(int)

# convert column "a" to int64 dtype and "b" to complex type
df = df.astype({"a": int, "b": complex})

# convert Series to float16 type
s = s.astype(np.float16)

# convert Series to Python strings
s = s.astype(str)

# convert Series to categorical type - see docs for more details
s = s.astype('category')

Notice I said "try" - if astype() does not know how to convert a value in the Series or DataFrame, it will raise an error. For example, if you have a NaN or inf value you'll get an error trying to convert it to an integer.

As of pandas 0.20.0, this error can be suppressed by passing errors='ignore'. Your original object will be returned untouched.

Be careful

astype() is powerful, but it will sometimes convert values "incorrectly". For example:

>>> s = pd.Series([1, 2, -7])
>>> s
0    1
1    2
2   -7
dtype: int64

These are small integers, so how about converting to an unsigned 8-bit type to save memory?

>>> s.astype(np.uint8)
0      1
1      2
2    249
dtype: uint8

The conversion worked, but the -7 was wrapped round to become 249 (i.e. 2⁸ - 7)!

Trying to downcast using pd.to_numeric(s, downcast='unsigned') instead could help prevent this error.

3. infer_objects()

Version 0.21.0 of pandas introduced the method infer_objects() for converting columns of a DataFrame that have an object datatype to a more specific type (soft conversions).

For example, here's a DataFrame with two columns of object type. One holds actual integers and the other holds strings representing integers:

>>> df = pd.DataFrame({'a': [7, 1, 5], 'b': ['3','2','1']}, dtype='object')
>>> df.dtypes
a    object
b    object
dtype: object

Using infer_objects(), you can change the type of column 'a' to int64:

>>> df = df.infer_objects()
>>> df.dtypes
a     int64
b    object
dtype: object

Column 'b' has been left alone since its values were strings, not integers. If you wanted to force both columns to an integer type, you could use df.astype(int) instead.

4. convert_dtypes()

Version 1.0 and above includes a method convert_dtypes() to convert Series and DataFrame columns to the best possible dtype that supports the pd.NA missing value.

Here "best possible" means the type most suited to hold the values. For example, this a pandas integer type, if all of the values are integers (or missing values): an object column of Python integer objects are converted to Int64, a column of NumPy int32 values, will become the pandas dtype Int32.

With our object DataFrame df, we get the following result:

>>> df.convert_dtypes().dtypes                                             
a     Int64
b    string
dtype: object

Since column 'a' held integer values, it was converted to the Int64 type (which is capable of holding missing values, unlike int64).

Column 'b' contained string objects, so was changed to pandas' string dtype.

By default, this method will infer the type from object values in each column. We can change this by passing infer_objects=False:

>>> df.convert_dtypes(infer_objects=False).dtypes                          
a    object
b    string
dtype: object

Now column 'a' remained an object column: pandas knows it can be described as an 'integer' column (internally it ran infer_dtype) but didn't infer exactly what dtype of integer it should have so did not convert it. Column 'b' was again converted to 'string' dtype as it was recognised as holding 'string' values.

Your solution is possible change with pass mask to loc function:

mask = df["Column3"]!="String1"
df.loc[mask,"Column3"] = df.loc[mask,"Column3"].astype(np.float64)

Another idea if convert all possible numeric, non numeric generate missing values, so replaced by original:

df['Column3'] = pd.to_numeric(df['Column3'], errors='coerce').fillna(df['Column3'])

For test is posible use checking type:

print (df['Column3'].apply(type))
0       <class 'str'>
1     <class 'float'>
2     <class 'float'>
3     <class 'float'>
4     <class 'float'>
5     <class 'float'>
6     <class 'float'>
7       <class 'str'>
8     <class 'float'>
9     <class 'float'>
10    <class 'float'>
11    <class 'float'>
12    <class 'float'>
13      <class 'str'>
14    <class 'float'>
Name: Column3, dtype: object

In my opinion still best should be only numeric column with missing values for non match values:

df['Column3'] = pd.to_numeric(df['Column3'], errors='coerce')

\xa0 is a non-breaking space (used as thousand separator here), which is not removed by your replace.

A safer approach might be to remove all non digits/dot/minus characters:

df = pd.DataFrame({'Profit': ['-$1\xa0000.00', '$605.00', '$680.00', '-$140.00 ']})

df['Profit'].str.replace('[^\d\.-]', '', regex=True).astype(float)

for only $ and \xa0:

df['Profit'].str.replace('[$\xa0]', '', regex=True).astype(float)

output:

0   -1000.0
1     605.0
2     680.0
3    -140.0
Name: Profit, dtype: float64