You also should validate the user input:

import sys

def is_intstring(s):
    try:
        int(s)
        return True
    except ValueError:
        return False

for arg in sys.argv[1:]:
    if not is_intstring(arg):
        sys.exit("All arguments must be integers. Exit.")

numbers = [int(arg) for arg in sys.argv[1:]]
sum = sum(numbers)

print "The sum of arguments is %s" % sum

I highly recommend argparse which comes with Python 2.7 and later.

The argparse module reduces boiler plate code and makes your code more robust, because the module handles all standard use cases (including subcommands), generates the help and usage for you, checks and sanitize the user input - all stuff you have to worry about when you are using sys.argv approach. And it is for free (built-in).

Here a small example:

import argparse

parser = argparse.ArgumentParser("simple_example")
parser.add_argument("counter", help="An integer will be increased by 1 and printed.", type=int)
args = parser.parse_args()
print(args.counter + 1)

and the output for python prog.py -h

usage: simple_example [-h] counter
    
positional arguments:
  counter     counter will be increased by 1 and printed.
    
optional arguments:
  -h, --help  show this help message and exit

and the output for python prog.py 1 As one would expect:

2

You need to skip sys.argv[0], which is the script's name:

for i in sys.argv[1:]:
    # ...

Everything on argv are strings. You need to manually convert them as integers, like:

value1 = int(argv[1])
value2 = int(argv[2])