There are two steps to created & populate a new column using only a row number... (in this approach iloc is not used)

First, get the row index value by using the row number

CopyrowIndex = df.index[someRowNumber]

Then, use row index with the loc function to reference the specific row and add the new column / value

Copydf.loc[rowIndex, 'New Column Title'] = "some value"

These two steps can be combine into one line as follows

Copydf.loc[df.index[someRowNumber], 'New Column Title'] = "some value"

You can use df.loc[i], where the row with index i will be what you specify it to be in the dataframe.

>>> import pandas as pd
>>> from numpy.random import randint

>>> df = pd.DataFrame(columns=['lib', 'qty1', 'qty2'])
>>> for i in range(5):
>>>     df.loc[i] = ['name' + str(i)] + list(randint(10, size=2))

>>> df
     lib qty1 qty2
0  name0    3    3
1  name1    2    4
2  name2    2    8
3  name3    2    1
4  name4    9    6

RukTech's answer, df.set_value('C', 'x', 10), is far and away faster than the options I've suggested below. However, it has been slated for deprecation.

Going forward, the recommended method is .iat/.at.

Why df.xs('C')['x']=10 does not work:

df.xs('C') by default, returns a new dataframe with a copy of the data, so

df.xs('C')['x']=10

modifies this new dataframe only.

df['x'] returns a view of the df dataframe, so

df['x']['C'] = 10

modifies df itself.

Warning: It is sometimes difficult to predict if an operation returns a copy or a view. For this reason the docs recommend avoiding assignments with "chained indexing".

So the recommended alternative is

df.at['C', 'x'] = 10

which does modify df.

In [18]: %timeit df.set_value('C', 'x', 10)
100000 loops, best of 3: 2.9 µs per loop

In [20]: %timeit df['x']['C'] = 10
100000 loops, best of 3: 6.31 µs per loop

In [81]: %timeit df.at['C', 'x'] = 10
100000 loops, best of 3: 9.2 µs per loop