Any of the Dell service programs are usually safe to remove and you'll probably find things run smoother without them. If you use the My Alienware app then you may need to keep Dell Fusion. Personally, I'd remove any of the extra Dell programs but that's your call. As for the *wonderful* Support Assist, go through your list of Programs in 'Uninstall a Program' and find anything that mentions it. There are usually 3 programs to remove before it's completely removed.

Hi @toll_booth  welcome to this user to user discussion forum. This is not Dell Support.  Currently Dell Support Drivers & Downloads says that the Alienware m15 series offers the Alienware Command Center (AWCC) Application Version 5.3.2.0, A00 and its AlienFX 2.0 application.  Users are encouraged to NOT update their AWCC version, but to use the fully functional AWCC version installed at the factory. Dell is required to provide its customers with a working version of their AWCC, but frequently fails because they lack the basic understanding of how AWCC compatibility functions within the Windows 10 operating system environment. Unfortunately the AWCC application is not standalone and makes use of Windows 10 Files, Folders and Registry entries, that are also used by other applications. Dell fails to support AWCC and fails provide any troubleshoot application to fix problems with loading AWCC, AlienFX 2.0, AWCC Home, FX, Fusion tabs. The AWCC self repair option does not work, and AWCC self uninstall does not remove all of its multiple files, folders, and/or Registry entries left behind within the Windows 10 operating system.  We have found that Revo Uninstaller Free will fully remove the AWCC (and OC Controls) application and its Advanced Scan Mode will then remove all the left behind items so that AWCC can be installed as if for the first time. AWCC must be installed so that Revo Uninstaller Free can remove it. AWCC might be installed, but fails to load with rotating circle of dots fault condition, use Revo Uninstaller Free.  Download Revo Uninstaller Free and Restart (not Shut Down). Open Revo Uninstaller Free and wait for it to load list of all installed applications on your system. Double click on Alienware Command Center (AWCC) to uninstall, click on create a restore point. Wait for AWCC to uninstall, Scan will change colour, click on Advanced, then click on Scan. AWCC will have two delete windows, click on Select everything, then click on Delete everything. The uninstall process will have completed when no more windows appear. Close Revo Uninstaller Free and wait for AWCC windows to appear and say process is successful. Restart (not Shut Down).  You are now ready to download the AWCC application onto your system, then install AWCC as if for the first time. Wait for AWCC to subsequently load its resources. The OC Controls install windows should automatically appear so that it can be installed and integrated within AWCC. Keep the AWCC window open so that the other resources are installed.  This is the fix for a bad AWCC install. There may be other AWCC problems, and the Reliability Monitor should be used to identify software issues.  Please click on Kudos to say thank you for response from user that is not employed by Dell. Please share an update on progress, so that other users derive benefit from your experience. Thank you.