Angular uses webpack and all type script files are listed under it. To select your target typescript file, Chrome's Developer tool (F12). Go to Source tab,
Select Chrome "webpack://"->"src/app" -> your typescript file.
Or in older version of chrome follow this path "webpack://"->"."->"src/app" -> your typescript file ( See the image file).
Or Ctrl+P to locate your file(as suggested by fergal_dd)
Then set the debug line marker on ts file and use normal java script keyboard(F8, F10, F11 etc) feature to debug it.

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Angular uses webpack and all type script files are listed under it. To select your target typescript file, Chrome's Developer tool (F12). Go to Source tab,
Select Chrome "webpack://"->"src/app" -> your typescript file.
Or in older version of chrome follow this path "webpack://"->"."->"src/app" -> your typescript file ( See the image file).
Or Ctrl+P to locate your file(as suggested by fergal_dd)
Then set the debug line marker on ts file and use normal java script keyboard(F8, F10, F11 etc) feature to debug it.

Steps:
- Open Chrome's Developer tool F12.
- Press Ctrl+P in Chrome Dev Tools to search a TS file and open it.
Also, you can copy the filename from the code and paste it in the search inputbox.
This is the best approach.
For Debug AngularJS in chrome you can use AngularJS Batarang.
Here is the Link for description and Demo:
Introduction of Angular JS Batarang
Download chrome plugin from here: chrome plugin for debug AngularJS
What about Chrome Developer Tools? In Chrome you don't need any extension..
See https://developers.google.com/chrome-developer-tools/ for reference.
There also exists a special Extension for debugging AngularJS: https://chrome.google.com/webstore/detail/angularjs-batarang/ighdmehidhipcmcojjgiloacoafjmpfk