1600 DPI (lower latency than 800DPI) and 1000Hz (higher than 1000Hz causes stutters in FN) in the mouse itself settings. Then mouse settings in FN choose something between 3% and 4% that feels good for you. Veno on 3%, Peterbot uses 3.2%, Eomzo 3.3, Muz 3.5%, Malibuca 4% (all when converted to 1600DPI). Then put ADS/scope on 40-50%, whatever feels best. I use 1600DPI 3.4% and 40% ADS, 1000Hz polling. Then keyboard settings: if you have adjustable actuation, put build+movement+edit keys on 0.1mm-0.4mm (whatever feels best, I use 0.4mm) and leave the rest of the keys on 1mm (I put WinKey+emotekey+ESC on 4mm so I don't hit them accidentally). Then binds (optimal is a myth, but many decent combos exist) : I prefer not to change too much beyond default as this can cause some bugs and loss of hidden binds down the line. Edit on E or F. Pickaxe on a different finger to shotgun to swap quickly. Divide build binds across hands and fingers, so Wall+stairs on mouse 4+5 (side mouse buttons, this is both ideal and default). Then put floor on Q and leave cone on V (press with thumb, both ideal and default). Don't forget to put scroll-up for pick-up/interact and scroll down as a second edit and second reset bind to be able to scroll-reset. Again, there's so many possible good binds to put pickaxe, AR and shotgun on. Its all down to whats comfortable but you want to be able to move left while pulling shotgun out. Many pros use 3, E or C, but a thumb bind would be good too. Good luck. Don't get caught up in changing your build binds a bunch. The ones I recommended or very similar are used by Veno, Eomzo and Cold for example. They will not limit your skill. Answer from d0rchadas on reddit.com