The best ones, as I worked with them, are XlsxWriter and xlwings. Both work smoothly and efficiently and are compatible with Python and Excel.

Xlwings Has two versions: Free and Pro (paid version). The free version can do almost anything you need to work with an Excel file. With the paid version, you can get more functionality and support, which developers (not regular users) do not usually need.

On the other hand, XlsxWriter It is also an excellent choice. Its user community has been growing fast recently. It supports everything you need to work with an Excel file.

Both can be installed simply with uv, pip and conda.

The other libraries, such as xlrd and xlwt (unfortunately, the maintainer hasn't updated it since Aug 22, 2017), were designed in the past to handle the old version (.xls) files. They are not comparable to the other two libraries that I mentioned.

OpenPyXl is also a decent library that can handle most of your needs. However, it needs more support to grow. In my opinion, it is not yet mature.

The pandas and the PyExcel libraries are also suitable for reading and writing data to an Excel file. I prefer pandas because it is a mature and efficient library that can handle large datasets. pyexcel is a wrapper API that is less capable than Pandas and more complicated to work with.

PyXLL is a professional library that can handle almost everything a user wants in Excel with Python. One of the famous companies working on Python distributions supports the library. Unfortunately, there is no free or community version of it, and you can only choose a 30-day trial of the pro version. After that, you must pay at least $29 (USD) per month, or $299 (USD) per year. It is powerful, but it is an expensive choice for a single developer.

IronXL is another library that offers a 30-day free trial. However, after that, the cheapest license (Lite) is $749 USD for one year, and you must pay for renewal each year with a discount, which is still expensive. I personally didn't try it, but as I saw what they offer, I don't know why it is so expensive.

Of course, there are more. Libraries, Wrapers and APIs for handling Excel files (for example, a list of some open source libraries can be found in Python for Excel), but the ones that I mentioned are the most mature and popular libraries.

Answer from Reza K Ghazi on Stack Overflow
Top answer
1 of 3
13

The best ones, as I worked with them, are XlsxWriter and xlwings. Both work smoothly and efficiently and are compatible with Python and Excel.

Xlwings Has two versions: Free and Pro (paid version). The free version can do almost anything you need to work with an Excel file. With the paid version, you can get more functionality and support, which developers (not regular users) do not usually need.

On the other hand, XlsxWriter It is also an excellent choice. Its user community has been growing fast recently. It supports everything you need to work with an Excel file.

Both can be installed simply with uv, pip and conda.

The other libraries, such as xlrd and xlwt (unfortunately, the maintainer hasn't updated it since Aug 22, 2017), were designed in the past to handle the old version (.xls) files. They are not comparable to the other two libraries that I mentioned.

OpenPyXl is also a decent library that can handle most of your needs. However, it needs more support to grow. In my opinion, it is not yet mature.

The pandas and the PyExcel libraries are also suitable for reading and writing data to an Excel file. I prefer pandas because it is a mature and efficient library that can handle large datasets. pyexcel is a wrapper API that is less capable than Pandas and more complicated to work with.

PyXLL is a professional library that can handle almost everything a user wants in Excel with Python. One of the famous companies working on Python distributions supports the library. Unfortunately, there is no free or community version of it, and you can only choose a 30-day trial of the pro version. After that, you must pay at least $29 (USD) per month, or $299 (USD) per year. It is powerful, but it is an expensive choice for a single developer.

IronXL is another library that offers a 30-day free trial. However, after that, the cheapest license (Lite) is $749 USD for one year, and you must pay for renewal each year with a discount, which is still expensive. I personally didn't try it, but as I saw what they offer, I don't know why it is so expensive.

Of course, there are more. Libraries, Wrapers and APIs for handling Excel files (for example, a list of some open source libraries can be found in Python for Excel), but the ones that I mentioned are the most mature and popular libraries.

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Below are a few libraries which do that. Recommend going through them as per your requirements.

  1. Pycel
  2. formulas
  3. Pandas
  4. xlwt
  5. Openpyxl

They all blend with excel really well. You can try these out.

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Reddit
reddit.com › r/learnpython › best excel library?
r/learnpython on Reddit: Best Excel Library?
November 3, 2022 -

Hi Community, I am new to Python and want do a project in Python with an Excel file. I want to read the data from two different cols and compair each pair to look if it is correct pair or not. What library would you recommend to do this, and what should I take in mind? Because I heard that working with excel is not easy task Thanks in advance

Discussions

excel - Best Python Module for Reading Data from .xlsx - Stack Overflow
I'm trying to read in data from .xlsx file and store the data in a list or preferably a dictionary in Python. I see there are many modules built for Python for interacting with .xlsx files like ope... More on stackoverflow.com
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parsing excel documents with python - Stack Overflow
I want to parse excel document to lists in Python. Is there a python library which is helpful for this action? And what functions are relevant in that library? More on stackoverflow.com
🌐 stackoverflow.com
Best Excel Library?
Are you good at excel already? That’s half the struggle right there. My first self-conceived project was reading an excel file with openpyxl. It wasn’t particularly hard and I’ve since done a ton of neat stuff using openpyxl to automate reports and stuff like that at work. The book ‘Automate the Boring Stuff’ has a pretty good primer on using openpyxl. Pandas is another option and their documentation/site has a 10 minute introduction tutorial that can get you started there. Pandas is definitely the way to go if you know you’ll need python to do the heavy lifting when it comes to working with the data itself. Openpyxl is good at interacting with excel files whereas pandas is more of a replacement for excel as the tool you use to interact with data. A pandas dataframe is conceptually very similar to an excel sheet. More on reddit.com
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37
November 3, 2022
Is Openxyl the best library to write on Excel?
I prefer xlsxwriter. More on reddit.com
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January 11, 2019
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DEV Community
dev.to › mhamzap10 › 7-python-excel-libraries-in-depth-review-for-developers-4hf4
7 Python Excel Libraries: In-Depth Review for Developers - DEV Community
July 19, 2024 - IronXL for Python is an advanced library that excels in creating, editing, and extracting data from Excel files. It provides a robust solution for users who need to work extensively with Excel files in a .NET framework context.
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Python-excel
python-excel.org
Python Resources for working with Excel - Working with Excel Files in Python
The recommended package for reading and writing Excel 2010 files (ie: .xlsx) ... An alternative package for writing data, formatting information and, in particular, charts in the Excel 2010 format (ie: .xlsx) ... Library with a unified api for reading and writing files with older Excel format (xls), Excel 2010 format (xlsx), OpenDocument Spreadsheet format (ods), and many others.
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LearnPython.com
learnpython.com › blog › python-package-for-excel
Best Python Packages for Excel | LearnPython.com
The pylightxl package is a lightweight, zero-dependency package that can read and write Excel files. The zero-dependency factor could be a compelling feature if you’re developing bigger projects, since this will avoid any compatibility issues with other software and make version control easier. Also, regardless of which version of Python you’re running (from Python 2.7.18 onwards), pylightxl will be compatible for life. After installing this library, you can import it and read in a file:
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Sheetflash
sheetflash.com › blog › the-best-python-libraries-for-excel-in-2024
The Best Python Libraries for Excel in 2025 | SheetFlash
Python, with its versatility, complements Excel by providing automation, data analysis, and task execution functionalities. Below are some of the most renowned Python libraries that cater to Excel operations. OpenPyXL is well-regarded for reading and writing Excel 2010 files (.xlsx).
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Excelpython
excelpython.org
Python for Excel - Best open-source Python libraries for working with Excel
409 Automate Excel with Python on Win & macOS. Works great for macros, UDFs, reporting, unit tests & REST API. ... 3 xlrd is a library for reading data and formatting information from Excel files, whether they are .xls or .xlsx files
Find elsewhere
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GeeksforGeeks
geeksforgeeks.org › python › reading-excel-file-using-python
Reading an excel file using Python - GeeksforGeeks
June 16, 2026 - ... Let's look at some examples of working with each library. Below is an image of the sample Excel data we are going to use in this article, click here to download it. pandas is the most popular library for ...
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Hakibenita
hakibenita.com › fast-excel-python
Fastest Way to Read Excel in Python | Haki Benita
January 3, 2024 - We now have a sample file, a way to test the contents and we've defined what to measure - we are ready to import some data! Pandas, the data analysis library for Python, is the go-to for just about anything related to data in Python, so it's ...
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Pythonexcel
pythonexcel.com
Python Excel - A Guide to Read/Write Excel Files in Python
It is a Python Library developed by Eric Gazoni and Charlie Clark to read and write Excel xlsx/xlsm/xltm/xltx files without using the Excel software. It is the most widely used library for python-excel purposes. It is an open source project, being non-commercial can have pros and cons.
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Iron Software
ironsoftware.com › ironxl for python › ironxl for python blog › product comparisons › best excel python library
Best Excel Python Library (List For Developers)
April 24, 2026 - OpenPyXL is a Python library tailored for handling Excel files in the XLSX format. The library allows developers to read, write, and modify Excel files
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Aspose
blog.aspose.com › aspose.blogs › aspose.cells for python – the best python excel library for developers
Aspose.Cells for Python – The Best Python Excel Library for Developers
August 13, 2025 - Discover why Aspose.Cells is the best Python Excel library for reading, writing, and manipulating XLSX files with powerful features and high performance.
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OpenPyXL
openpyxl.readthedocs.io
openpyxl - A Python library to read/write Excel 2010 xlsx/xlsm files — openpyxl 3.1.3 documentation
It was born from lack of existing library to read/write natively from Python the Office Open XML format.
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PyXLL
pyxll.com › blog › tools-for-working-with-excel-and-python
Tools for Working with Excel and Python – PyXLL
August 13, 2018 - If you need to read Excel files to extract data then OpenPyXL can do that too. The Excel file types are incredibly complicated and openpyxl does an amazing job of reading them into a form that’s easy to access in Python.
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Medium
medium.com › @ghanshyamsavaliya › 11-most-popular-ways-to-read-excel-files-in-python-ae0c37b7dfd9
11 most popular ways to read Excel files in python | by Ghanshyam Savaliya | Medium
February 17, 2023 - Here are the 11 most popular ways to read Excel files in Python with examples: The csv module is a built-in Python library for working with CSV files. It provides a simple and efficient way to read CSV files.
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Iron Software
ironsoftware.com › ironxl for python › ironxl for python blog › product comparisons › python excel library
Python Excel Library (Beginner-Friendly Guide)
August 1, 2026 - More generally, other libraries would be better suited to more widely used formats such as .XLSX, and it's far from the best suited to process binary format files. IronXL is a full-featured Python/.NET library for opening and writing Excel files in both .XLSX as well as .XLS format. The library will provide the utmost features as possible in creating, reading, and manipulating spreadsheets, so developers can build their automation on top of all things that can be done with Excel without installing Microsoft Excel.