It is because of JavaScript that captures your clicks and, because of that, interferes with your keyboard shortcuts. If you disable JavaScript then shortcuts should start to work again. You can test it by pressing CTRL+SHIFT+I (Developer tools), then clicking Settings (gear icon) and enabling option Disable JavaScript.

Answer from pvc on Stack Exchange
Discussions

Ctrl+Right click closes Google Chrome - Google Chrome Community
Skip to main content · Google Chrome Help · Sign in · Google Help · Help Center · Community · Google Chrome · Terms of Service · Submit feedback · Send feedback on More on support.google.com
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September 18, 2022
Ctrl+click isn't opening links in my VS Code with Google Chrome - Stack Overflow
And Ctrl + click also works. Whether it's permanently working remains to be seen. 2024-02-11T13:36:16.327Z+00:00 ... Answer from JimmyTheCode helped me to debug it, but to fix the issue, I needed to close and open chrome additionally ... This does not provide an answer to the question. More on stackoverflow.com
🌐 stackoverflow.com
CTRL-Click often doesn't open new tab
This normally works for links in many browsers. If I right-click and then choose “open in new tab” it does work. I love using CTRL-click and this is kind of a nuisance. I’m on: Mac OS 10.10 SuiteCRM 7.4.1 & 7.7.4 Chrome, Safari, Firefox Anybody else notice this? More on community.suitecrm.com
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June 27, 2017
Ctrl+Click and Shift+Click do not open new tabs/windows in search results - Meta Stack Overflow
For example, when Ctrl+Click-ing on any link in https://stackoverflow.com/search?q=foobar, the operation is treated as a normal click. I can still use "Open in new tab" in the context menu, but that's quite a bit slower. I can reproduce this behavior in Firefox and Chrome for Windows. This behavior does not appear on a few other SE sites I tested. ... Works ... More on meta.stackoverflow.com
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Google Support
support.google.com › chrome › thread › 85091722 › ctrl-click-not-allowing-multiple-selections-anymore
CTRL + click not allowing multiple selections anymore - Google Chrome Community
November 24, 2020 - Google Chrome · false · Search · Clear search · Close search · Google apps · Main menu · 10245221157133569088 · true · Search Help Center · false · true · true · true · true · true · 237 · false ·
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Geekzone
geekzone.co.nz › forums.asp
Chrome: control click no longer opens links in a new tab
No issues for me either, with ctrl click, middle mouse click. 20984 posts Uber Geek +1 received by user: 5427 Trusted Lifetime subscriber ... I did a malware scan today. Anyway, malware wouldn't prevent you opening pop-ups so much as make more. Based on link above it seems like a bug in Windows / Chrome. Uploads are also broken, here on Geekzone and other forums. ... @freitasm also related to the latest chrome version on this forum. I have noticed on two devices that if you use Shift+Enter it will go to the immediate line below as expected.
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Google Support
support.google.com › chrome › thread › 179904455 › ctrl-right-click-closes-google-chrome
Ctrl+Right click closes Google Chrome - Google Chrome Community
September 18, 2022 - Skip to main content · Google Chrome Help · Sign in · Google Help · Help Center · Community · Google Chrome · Terms of Service · Submit feedback · Send feedback on
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SuiteCRM
community.suitecrm.com › 💬 general discussion
CTRL-Click often doesn't open new tab - 💬 General Discussion - SuiteCRM
June 27, 2017 - This normally works for links in many browsers. If I right-click and then choose “open in new tab” it does work. I love using CTRL-click and this is kind of a nuisance. I’m on: Mac OS 10.10 SuiteCRM 7.4.1 & 7.7.4 Chrome, Safari, Firefox Anybody else notice this?
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Reddit
reddit.com › r/chrome › feel like i'm going crazy - ctrl shortcuts not working and weird "close" box in top-right
r/chrome on Reddit: Feel like I'm going crazy - Ctrl shortcuts not working and weird "close" box in top-right
May 21, 2024 - This week my Ctrl shortcuts stopped working in Chrome, unless I directly click on the browser window. If I do so and, for example, close a tab via ctrl + W, the remaining browser page is unselected and I can't Ctrl shortcut on that page again until I click it, including Ctrl + Tab. Obviously super annoying from an efficiency standpoint. I also noticed in these instances I'm getting a weird "Close" box in the top right of my browser window.
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Windows 10 Forums
tenforums.com › browsers-email › 199782-browser-ctrl-click-open-tab-not-working-no-context-menu-either.html
Browser: Ctrl+click to open tab not working (no context menu either) - Windows 10 Help Forums
Hi, This might not be a Windows 10 specific problem but I know it's also not a browser-specific problem either because I can reproduce it on several different browsers (Chrome, Firefox, Edge). I'm on website where I absolutely need to be able to open links in a separate tab but am unable to. Right-clicking for the context-menu doesn't display the usual 'open in a new tab' and Ctrl+click or Shift+click doesn't work either.
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Reddit
reddit.com › r/todoist › ctrl + click no longer opening in new chrome tab
r/todoist on Reddit: Ctrl + Click no longer opening in new chrome tab
May 26, 2023 -

Hello. I use Ctrl+Click often to open new tabs so that I can go back the the original list easily. As of today, it no longer works. When I hold Ctrl and click nothing happens. Did something change?

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Google Support
support.google.com › chrome › thread › 5688613 › ctrl-shift-shortcuts-not-working-in-chrome
CTRL + SHIFT shortcuts not working in Chrome - Google Chrome Community
Skip to main content · Google Chrome Help · Sign in · Google Help · Help Center · Community · Google Chrome · Terms of Service · Submit feedback · Send feedback on
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Google Support
support.google.com › chrome › thread › 3535810 › keyboard-shortcut-not-working-consistently-in-chrome
Keyboard shortcut not working consistently in Chrome - Google Chrome Community
April 3, 2019 - Skip to main content · Google Chrome Help · Sign in · Google Help · Help Center · Community · Google Chrome · Terms of Service · Submit feedback · Send feedback on
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ASUS
koskila.net › how-to-solve-keyboard-shortcuts-not-working-in-google-chrome-on-windows
How to solve keyboard shortcuts not working in Google Chrome on Windows? - Koskila.net
September 10, 2024 - Restarting Chrome would always clear the issue, until it came up (usually right after hitting Ctrl+W or similar key combination!) and while restarting my PC would clear the issue for hours or days, that didn't feel like a sustainable option.
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Adobe Support Community
community.adobe.com › home › app communities › using the community › bug reports › cmd/ctrl click to open a thread in a new tab recently broken
Cmd/Ctrl click to open a thread in a new tab recently broken | Community
June 9, 2026 - If you disable JavaScript then shortcuts should start to work again. You can test it by pressing CTRL+SHIFT+I (Developer tools), then clicking Settings (gear icon) and enabling option Disable JavaScript.”
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Google Support
support.google.com › chrome › thread › 268713239 › ctrl-click-to-open-and-bring-link-to-front
CTRL + Click to open and bring link to front - Google Chrome Community
April 10, 2024 - Skip to main content · Google Chrome Help · Sign in · Google Help · Help Center · Community · Google Chrome · Terms of Service · Submit feedback · Send feedback on
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ServiceNow
support.servicenow.com › kb
On a Windows machine, while using chrome, using CTRL+Click(left Click) on the 'i' button on a list view does not open the record in a new tab. - Known Error - Now Support Portal
April 7, 2024 - On a list view of records, using CTRL+Click(left Click) on the 'i' button is expected to open up the specific record in a new tab. This is working fine for Versions prior to Kingston for both IE and Chrome