It is because of JavaScript that captures your clicks and, because of that, interferes with your keyboard shortcuts. If you disable JavaScript then shortcuts should start to work again. You can test it by pressing CTRL+SHIFT+I (Developer tools), then clicking Settings (gear icon) and enabling option Disable JavaScript.

Hi @Lucie

Based on the information you shared, I understand that you are unable to copy content within Excel on the Web when using Google Chrome on your Mac. While pasting external content works fine, both the Command+C shortcut and the right-click "Copy" option fail to copy cells within a shared SharePoint Excel file. You have already cleared your cache, and while the copy function works in Firefox and other Mac apps, you need to use Chrome for your workflow.

I have tested this in our own environment, and the copy/paste functionality in Excel on the Web is currently working as expected. Because of this, the behavior you are experiencing can sometimes occur under certain conditions specific to the local browser environment. This may be related to how Chrome is handling clipboard permissions, a conflict with a browser extension, or synchronization behavior between this specific shared file and the web client. To help me isolate the exact cause, let's walk through a few structured steps:

-Test the Ribbon Copy Button: Instead of using the keyboard shortcut or the right-click menu, please try selecting a cell and clicking the physical "Copy" button located on the Home tab of the Excel Web ribbon at the top of the screen. Let me know if you still experience the same behavior when using this button, as this interacts with the clipboard slightly differently.

-Test in Incognito Mode: Please open an Incognito window in Chrome (which temporarily disables extensions and uses a fresh session) and log in to your Excel on the Web file. Try to copy and paste there. If it works perfectly in Incognito mode, this indicates a conflict with your standard Chrome profile or extensions. If this is the case, I recommend reinstalling Google Chrome or resetting your Chrome profile settings.

-Isolate the File: Could you please let me know if this behavior happens with both your older existing files and brand-new files? Try creating a completely new, blank Excel workbook online and see if the copy function works there. This helps me determine if the behavior is tied to the specific shared file or the browser itself.

To ensure I am looking at the right environment details, could you please confirm which Microsoft 365 subscription plan you are currently using (for example, Microsoft 365 Business Standard, Enterprise E3, Family, etc.)?

Because we do not have full visibility into your specific local environment, gathering these extra details will help me pinpoint the cause and provide you with the possible resolution.

Thank you for your understanding.

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