All columns convertible

You can apply the function to all columns:

df.apply(pd.to_numeric)

Example:

>>> df = pd.DataFrame({'a': ['1', '2'], 
                       'b': ['45.8', '73.9'],
                       'c': [10.5, 3.7]})

>>> df.info()
<class 'pandas.core.frame.DataFrame'>
Int64Index: 2 entries, 0 to 1
Data columns (total 3 columns):
a    2 non-null object
b    2 non-null object
c    2 non-null float64
dtypes: float64(1), object(2)
memory usage: 64.0+ bytes

>>> df.apply(pd.to_numeric).info()
<class 'pandas.core.frame.DataFrame'>
Int64Index: 2 entries, 0 to 1
Data columns (total 3 columns):
a    2 non-null int64
b    2 non-null float64
c    2 non-null float64
dtypes: float64(2), int64(1)
memory usage: 64.0 bytes

Not all columns convertible

pd.to_numeric has the keyword argument errors:

  Signature: pd.to_numeric(arg, errors='raise')
  Docstring:
  Convert argument to a numeric type.

Parameters
----------
arg : list, tuple or array of objects, or Series
errors : {'ignore', 'raise', 'coerce'}, default 'raise'
    - If 'raise', then invalid parsing will raise an exception
    - If 'coerce', then invalid parsing will be set as NaN
    - If 'ignore', then invalid parsing will return the input

Setting it to ignore will return the column unchanged if it cannot be converted into a numeric type.

As pointed out by Anton Protopopov, the most elegant way is to supply ignore as keyword argument to apply():

>>> df = pd.DataFrame({'ints': ['3', '5'], 'Words': ['Kobe', 'Bryant']})
>>> df.apply(pd.to_numeric, errors='ignore').info()
<class 'pandas.core.frame.DataFrame'>
Int64Index: 2 entries, 0 to 1
Data columns (total 2 columns):
Words    2 non-null object
ints     2 non-null int64
dtypes: int64(1), object(1)
memory usage: 48.0+ bytes

My previously suggested way, using partial from the module functools, is more verbose:

>>> from functools import partial
>>> df = pd.DataFrame({'ints': ['3', '5'], 
                       'Words': ['Kobe', 'Bryant']})
>>> df.apply(partial(pd.to_numeric, errors='ignore')).info()
<class 'pandas.core.frame.DataFrame'>
Int64Index: 2 entries, 0 to 1
Data columns (total 2 columns):
Words    2 non-null object
ints     2 non-null int64
dtypes: int64(1), object(1)
memory usage: 48.0+ bytes

To modify the float output do this:

df= pd.DataFrame(range(5), columns=['a'])
df.a = df.a.astype(float)
df

Out[33]:

          a
0 0.0000000
1 1.0000000
2 2.0000000
3 3.0000000
4 4.0000000

pd.options.display.float_format = '{:,.0f}'.format
df

Out[35]:

   a
0  0
1  1
2  2
3  3
4  4