This is kinda straightforward solution which shows the idea, also code isn`t very pythonic but for simplicity i think its good enough. Ok as example we want to fit equation of a kind y = ax^2 + bx + c to a data obtained from equation y = x^2. It obvious that parameter a = 1 and b,c should equal to 0. Since differential evolution algorithm finds minimum of a function we want to find a minimum of a root mean square deviation (again, for simplicity) of analytic solution of general equation (y = ax^2 + bx + c) with given parameters (providing some initial guess) vs "experimental" data. So, to the code:

from scipy.optimize import differential_evolution

def func(parameters, *data):

    #we have 3 parameters which will be passed as parameters and
    #"experimental" x,y which will be passed as data

    a,b,c = parameters
    x,y = data

    result = 0

    for i in range(len(x)):
        result += (a*x[i]**2 + b*x[i]+ c - y[i])**2

    return result**0.5

if __name__ == '__main__':
    #initial guess for variation of parameters
    #             a            b            c
    bounds = [(1.5, 0.5), (-0.3, 0.3), (0.1, -0.1)]

    #producing "experimental" data 
    x = [i for i in range(6)]
    y = [x**2 for x in x]

    #packing "experimental" data into args
    args = (x,y)

    result = differential_evolution(func, bounds, args=args)
    print(result.x)
Answer from Tierprot B. on Stack Overflow
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SciPy
docs.scipy.org โ€บ doc โ€บ scipy โ€บ reference โ€บ generated โ€บ scipy.optimize.differential_evolution.html
differential_evolution โ€” SciPy v1.17.0 Manual
The default is โ€˜best1binโ€™. Strategies that may be implemented are outlined in โ€˜Notesโ€™. Alternatively the differential evolution strategy can be customized by providing a callable that constructs a trial vector.
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Pablormier
pablormier.github.io โ€บ 2017 โ€บ 09 โ€บ 05 โ€บ a-tutorial-on-differential-evolution-with-python
A tutorial on Differential Evolution with Python | Pablo Rodriguez-Mier
September 5, 2017 - Differential Evolution (DE) is a very simple but powerful algorithm for optimization of complex functions that works pretty well in those problems where other techniques (such as Gradient Descent) cannot be used. In this post, weโ€™ve seen how to implement it in just 27 lines of Python with Numpy, and weโ€™ve seen how the algorithm works step by step.
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Nry
nry.me โ€บ posts โ€บ 2017-08-27 โ€บ simple-differential-evolution-with-python
Differential Evolution Optimization from Scratch with Python
August 27, 2017 - Putting everything together, adding a few lines for text output, score keeping, and some example cost functions, the final code looks like this (github repository -> here): #------------------------------------------------------------------------------+ # # Nathan A. Rooy # A simple, bare bones, implementation of differential evolution with Python # August, 2017 # #------------------------------------------------------------------------------+ #--- IMPORT DEPENDENCIES ------------------------------------------------------+ import random #--- EXAMPLE COST FUNCTIONS ---------------------------------------------------+ def func1(x): # Sphere function, use any bounds, f(0,...,0)=0 return sum([x[i]**2 for i in range(len(x))]) def func2(x): # Beale's function, use bounds=[(-4.5, 4.5),(-4.5, 4.5)], f(3,0.5)=0.
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MachineLearningMastery
machinelearningmastery.com โ€บ home โ€บ blog โ€บ differential evolution from scratch in python
Differential Evolution from Scratch in Python - MachineLearningMastery.com
October 12, 2021 - How to implement the differential evolution algorithm from scratch in Python. How to apply the differential evolution algorithm to a real-valued 2D objective function. ... It provides self-study tutorials with full working code on: Gradient Descent, Genetic Algorithms, Hill Climbing, Curve Fitting, RMSProp, Adam, and much more...
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ScienceDirect
sciencedirect.com โ€บ science โ€บ article โ€บ pii โ€บ S2352711024003844
DetPy (Differential Evolution Tools): A Python toolbox for solving optimization problems using differential evolution - ScienceDirect
January 2, 2025 - The library we designed, DetPy (Differential Evolution Tools), provides implementations of the standard differential evolution algorithm along with 15 distinct variants. This tool allows researchers working on optimization problems to compare ...
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PyMoo
pymoo.org โ€บ algorithms โ€บ soo โ€บ de.html
DE: Differential Evolution โ€” pymoo: Multi-objective Optimization in Python 0.6.1.6 documentation
The classical single-objective differential evolution algorithm [13] is where different crossover variations and methods can be defined.
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MachineLearningMastery
machinelearningmastery.com โ€บ home โ€บ blog โ€บ differential evolution global optimization with python
Differential Evolution Global Optimization With Python - MachineLearningMastery.com
October 12, 2021 - Click to sign-up and also get a free PDF Ebook version of the course. Start your FREE Mini-Course now! The Differential Evolution global optimization algorithm is available in Python via the differential_evolution() SciPy function.
Find elsewhere
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GitHub
github.com โ€บ nathanrooy โ€บ differential-evolution-optimization
GitHub - nathanrooy/differential-evolution-optimization: A simple, bare bones, implementation of differential evolution optimization.
A simple, bare bones, implementation of differential evolution optimization that accompanies a tutorial I made which can be found here: https://nathanrooy.github.io/posts/2017-08-27/simple-differential-evolution-with-python/
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Datatechnotes
datatechnotes.com โ€บ 2022 โ€บ 04 โ€บ differential-evolution-optimization.html
DataTechNotes: Differential Evolution Optimization Example in Python
September 1, 2022 - In this blog post, we'll explore the basics of Differential Evolution and demonstrate its application on a specific function using the SciPy differential_evolution() function in Python. ... We'll start by loading the required libraries. import numpy as np from scipy.optimize import differential_evolution import matplotlib.pyplot as plt from matplotlib import cm ... We'll start creating the objective function to optimize and visualize it in a 3D plot. In below code, we'll define ranges and function in a mesh grid then visualize it in a plot.
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GitHub
github.com โ€บ hpparvi โ€บ PyDE
GitHub - hpparvi/PyDE: Differential evolution global optimization in Python.
Global optimization using differential evolution in Python [Storn97].
Starred by 34 users
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GitHub
github.com โ€บ tiagoCuervo โ€บ EvoFuzzy
GitHub - tiagoCuervo/EvoFuzzy: A Python implementation of the Differential Evolution algorithm for the optimization of Fuzzy Inference Systems.
A Python implementation of the Differential Evolution algorithm for the optimization of Fuzzy Inference Systems. - tiagoCuervo/EvoFuzzy
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GitHub
github.com โ€บ smkalami โ€บ ypde
GitHub - smkalami/ypde: Differential Evolution in Python
# External Libraries import numpy as np import matplotlib.pyplot as plt from ypstruct import structure # From This Project import de import benchmarks # Problem Definition problem = structure() problem.objfunc = benchmarks.rastrigin # See benchmarks module for other functions problem.nvar = 100 problem.varmin = -10 problem.varmax = 10 # Parameters of Differential Evolution (DE) params = structure() params.maxit = 1000 params.npop = 100 params.F = 0.2 params.CR = 0.4 params.DisplayInfo = True # Run DE out = de.run(problem, params) # Print Final Result print("Final Best Solution: {0}".format(out.bestsol)) # Plot of Best Costs History plt.semilogy(out.bestcosts) plt.xlim(0, params.maxit) plt.xlabel("Iterations") plt.ylabel("Best Cost") plt.title("Differential Evolution") plt.grid(True) plt.show()
Author ย  smkalami
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Towards Data Science
towardsdatascience.com โ€บ home โ€บ latest โ€บ pymoode: differential evolution in python
pymoode: Differential Evolution in Python | Towards Data Science
January 17, 2025 - In this article, the Python package [pymoo](https://pymoo.org/)de was presented with tutorials for solving single-, multi-, and many-objective problems. The package is an extension of pymoo focusing on Differential Evolution algorithms, with a variety of operators that ensure great performance and allow high customization. All the code used to produce this article is available on Github.
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GitConnected
levelup.gitconnected.com โ€บ full-guide-to-implementing-differential-evolution-in-python-9fc7fdeccaa8
A Guide to Implementing Differential Evolution In Python | Level Up Coding
January 21, 2025 - In this guide, we covered the core components of the Differential Evolution algorithm and its Python implementation. The example that we went through and the Python code provided showed the simple process of optimization with this algorithm, its advantages, and its shortcomings.
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Medium
medium.com โ€บ @shubham.k.dokania โ€บ evolutionary-algorithms-i-differential-evolution-4d60b8f4e79b
Evolutionary Algorithms I: Differential Evolution | by Shubham Dokania | Medium
May 17, 2018 - One such algorithm belonging to the family of Evolutionary Algorithms is Differential Evolution (DE) algorithm. In this post, we shall be discussing about a few properties of the Differential Evolution algorithm while implementing it in Python (github link) for optimizing a few test functions.
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Evolutionary Genius
evolutionarygenius.com โ€บ home โ€บ python code for differential evolution algorithm
Python Code for Differential Evolution Algorithm - Evolutionary Genius
July 29, 2023 - Here we will learn step-by-step implementation of the Python Code for Differential Evolution Algorithm. DE is fast, easy-to-implement and robust optimizer.
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GitHub
github.com โ€บ xKuZz โ€บ pyade
GitHub - xKuZz/pyade: Python Advanced Differential Evolution
PyADE is a Python package that allows any user to use multiple differential evolution algorithms allowing both using them without any knowledge about what they do or to specify control parameters to obtain optimal results while your using this ...
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Python Guides
pythonguides.com โ€บ scipy-differential-evolution
Python SciPy Differential Evolution
June 24, 2025 - Learn how to use Python SciPy's differential evolution algorithm to solve complex optimization problems with constraints. Includes examples and performance tips