human disease

Molecular structure of the thyroxine molecule
Hypothyroidism
Hypothyroidism
Photograph of a Labrador Retriever dog with sagging facial skin characteristic of hypothyroidism
signs and symptoms of hypothyroidism
Hypothyroidism is an endocrine disease in which the thyroid gland does not produce enough thyroid hormones. It can cause a number of symptoms, such as poor ability to tolerate cold, extreme fatigue, … Wikipedia
Factsheet
Hypothyroidism Molecular structure of thyroxine, which is deficient in hypothyroidism
Specialty Endocrinology
Factsheet
Hypothyroidism Molecular structure of thyroxine, which is deficient in hypothyroidism
Specialty Endocrinology
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Paloma Health
palomahealth.com › learn › hypothyroid-without-hashimotos
Can You Be Hypothyroid Without Hashimoto’s? | Paloma Health
August 22, 2024 - What if you’ve been diagnosed with hypothyroidism, but antibody tests show no evidence of Hashimoto’s? What caused your hypothyroidism? Ahead, a look at how you can be hypothyroid without testing positive for Hashimoto’s disease.
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NIDDK
niddk.nih.gov › home › health information › endocrine diseases › hypothyroidism (underactive thyroid)
Hypothyroidism (Underactive Thyroid) - NIDDK
October 3, 2025 - Less often, hypothyroidism is caused by too much or too little iodine in the diet or by disorders of the pituitary gland or hypothalamus.1 Iodine deficiency, however, is extremely rare in the United States. Hashimoto’s disease, an autoimmune disorder, is the most common cause of hypothyroidism.
Discussions

Hashimoto’s without hypothyroid?
There is a lot of us yeah. So basically your body starts to attack your thyroid by making TPO and sometimes Tg antibodies. This is Hashimoto's. The presence of antibodies and active attack of your thyroid. Eventually it will start to become damaged enough that your TSH will be high on lab tests. TSH is a hormone that the pituitary gland makes and send to your thyroid to tell it to make T3 and T4 hormones. When your TSH is high on a lab that means that your body does not have enough TSH, so it is low. Confusing, right? This is subclinical hypothyroidism. Once your T4 is low your are considered to have full blown hypothyroidism. That means your body is not making enough to meet the demands of your body that is when you are supposedly supposed to feel symptoms. Can you go your whole life without having hypothyroidism? I guess in theory. I have no idea how long people go on average before their thyroid starts to die. Can they go for decades? Does it depend on what it started? I am not sure. Personally, I was diagnosed in June, but the year before had subclinical hypothyroidism. Mine went back to normal when I cut out gluten. Does that work for everyone? no. More on reddit.com
🌐 r/Hashimotos
42
7
November 14, 2022
Hashimoto's diagnosis without hypothyroidism: recommended lifestyle changes?

You are in the same boat as my kid. Autoantibodies, but thyroid still functioning. If you are lucky, you can go for years before needing thyroid hormone replacement.

I have had Hashimoto’s for over 25 years and have never seen an endocrinologist. Treatment for Hashimoto’s is not rocket science. Medication is based on thyroid panel results and with patient input. I do see a gastroenterologist because I have celiac disease and autoimmune gastritis. He/she has the equipment to look into my gut. Since you have GI problems, please rule out celiac disease before altering your diet or risk being stuck in diagnostic limboland.

Lifestyle changes do help manage symptoms. Work on things like good sleep to help with fatigue which is common with ANY autoimmune disease. Get some sun. I never need vitamin D supplements. I am sitting outside now soaking up a cool winter day. I walk my dog daily and cycle. The sun and nature is good for the body and the mind. Reducing stress is important. I learned that you cannot be good at everything. Pick and choose what makes you happy. Check your other hormones. Your thyroid is just one of many. Insulin is a hormone that can contribute to weight gain. Reducing carb intake can make a huge difference if insulin resistant. 70% of the U.S. population is overweight or obese and not all of them have a thyroid problem. Weight loss is so complicated. Start by eliminating as much ultra processed foods. Hard to overdose on fresh veg and fruit compared to a bag of chips.

Research is your best defense. You can life a long and healthy life, but there is no magic cure. Just hard work. I wish you well.

More on reddit.com
🌐 r/Hashimotos
1
3
January 16, 2023
What is the difference between hashimotos and hypothyroidsim
Basically, Hashimoto’s is the disease that caused your hypothyroidism. Hashimoto’s is an autoimmune disease that causes your immune system to attack your thyroid and destroy the thyroid tissue. Once the thyroid is damaged, it can no longer make enough thyroid hormone, leading to hypothyroidism. Your thyroid hormone replacement medication (levothyroxine) addresses the hypothyroidism, but not the disease that causes it (Hashimoto’s). More on reddit.com
🌐 r/Hashimotos
47
26
March 15, 2024
Hashimoto’s but no treatment

I mean… it sounds like you need treatment. 50 pounds in a year is insane, and can cause so many health problems down river (which I’m sure you know). When you get your thyroid labs done, be sure to get them done first thing in the morning before eating. This is when your TSH will be the highest, and you need to treat to that number. Also be sure you aren’t taking biotin. 4.7 is still too high.

Maybe ask for an endo referral? If you’re a woman of child bearing age and it’s easier to see a gyn than an endo, they may be more prone to treat you compared to your pcp.

More on reddit.com
🌐 r/Hypothyroidism
19
6
September 14, 2022
People also ask

What can be mistaken for Hashimoto's disease?
Like with other causes of hypothyroidism, the symptoms of Hashimotos can be vague. Many aspects of your health and well-being could be affected by the disease, such as your: Energy levels Hair and nails Weight Mood Sleep Digestion Menstrual periods It can be hard to piece it all together. As a result, Hashimotos can easily be mistaken for other conditions, including but not limited to: Menopause Chronic fatigue syndrome Depression Anxiety Irritable bowel syndrome Premenstrual syndrome ( PMS )
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goodrx.com
goodrx.com › goodrx health › health conditions › hypothyroidism: symptoms, causes, and treatments › hashimoto’s thyroiditis vs. hypothyroidism: what to know
Hashimoto’s Thyroiditis vs. Hypothyroidism: What to Know - GoodRx
What does a Hashimoto's flare feel like?
When thyroid hormone levels drop, this can cause more noticeable symptoms, like: Tremors Weight loss Fast heart rate Joint pains Muscle weakness Symptoms can differ between women and men .
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goodrx.com
goodrx.com › goodrx health › health conditions › hypothyroidism: symptoms, causes, and treatments › hashimoto’s thyroiditis vs. hypothyroidism: what to know
Hashimoto’s Thyroiditis vs. Hypothyroidism: What to Know - GoodRx
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Endocrine Society
endocrine.org › patient-engagement › endocrine-library › hashimoto-disease
Hashimoto Disease | Endocrine Society
March 31, 2022 - Most people with Hashimoto disease have these antibodies, but people whose hypothyroidism is caused by other conditions may not. TPO antibodies may also be present in normal people without hypothyroidism.
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GoodRx
goodrx.com › goodrx health › health conditions › hypothyroidism: symptoms, causes, and treatments › hashimoto’s thyroiditis vs. hypothyroidism: what to know
Hashimoto’s Thyroiditis vs. Hypothyroidism: What to Know - GoodRx
August 9, 2024 - But in Hashimoto’s, the body creates antibodies that mistakenly attack the thyroid. Sometimes, this destruction is so widespread that it leads to hypothyroidism (but not always). Scientists still aren’t exactly sure what triggers the immune system to attack the thyroid in · Hashimoto’s disease.
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Drtsoukalas
drtsoukalas.com › why_many_patients_with_hashimoto_s_thyroiditis_do_not_feel_well_despite_their_thyroid_function_tests_appearing_normal-lp-7.html
Why many Patients with Hashimoto`s Thyroiditis do not Feel Well Despite their Thyroid Function tests Appearing Normal - Dr Tsoukalas
To our clinical experience, even when the thyroid gland is under-functioning by up to 80%, this can be corrected through hormonal replacement without negatively affecting the patient's quality of life. The remaining 20% of the gland's function can cover a significant percentage of usual adjustments of metabolism to the needs of daily life, allowing an excellent quality of life. Therefore, it is essential to maintain any remaining gland function, allowing the body to adapt to these changes metabolically. To significantly improve health in patients with Hashimoto's disease, treatment must go beyond just regulating thyroid hormones.
Find elsewhere
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NHS
nhs.uk › conditions › underactive-thyroid-hypothyroidism
Underactive thyroid (hypothyroidism) - NHS
If you have Hashimoto's disease, your immune system attacks your thyroid gland meaning it cannot make enough thyroid hormone.
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American Association of Clinical Endocrinology
aace.com › disease-and-conditions › thyroid › what-hashimotos-disease
What Is Hashimoto's Disease? | American Association of Clinical Endocrinology
Thyroid hormone therapy is not needed if the thyroid is functioning normally, since it doesn't help with symptoms in that setting. Treatment of hypothyroidism caused by Hashimoto’s disease generally consists of taking a single daily tablet of levothyroxine.
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Mayo Clinic
mayoclinic.org › diseases-conditions › hashimotos-disease › symptoms-causes › syc-20351855
Hashimoto's disease-Hashimoto's disease - Symptoms & causes - Mayo Clinic
April 30, 2025 - A myxedema coma may be triggered by exposure to cold, sedatives, infection or other stress on your body. Myxedema requires immediate emergency medical treatment. ... Hashimoto's thyroiditis (lymphocytic thyroiditis).
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UpToDate
uptodate.com › contents › disorders-that-cause-hypothyroidism
Disorders that cause hypothyroidism
UpToDate, the evidence-based clinical decision support resource from Wolters Kluwer, is trusted at the point of care by clinicians worldwide.
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Mayo Clinic
mayoclinic.org › diseases-conditions › hypothyroidism › symptoms-causes › syc-20350284
Hypothyroidism (underactive thyroid) - Symptoms and causes - Mayo Clinic
December 10, 2022 - Understand what happens when your thyroid is underactive and learn about treatment for this condition.
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American Thyroid Association
thyroid.org › home › hashimoto’s thyroiditis
Hashimoto’s Thyroiditis | American Thyroid Association
August 25, 2023 - Hashimoto’s thyroiditis often progresses very slowly over many years. You may not have any symptoms early on, even if thyroid antibodies are detected in your blood tests. In some cases, the inflammation can cause your thyroid gland to become bigger than normal (goiter), which may cause neck discomfort, pressure or difficulty swallowing. Your thyroid gland may become underactive causing your thyroid hormone levels to be low (see Hypothyroidism ...
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Verywell Health
verywellhealth.com › hashimotos-disease-treatment-3233013
How Hashimoto's Disease Is Treated
October 9, 2025 - Lifestyle changes, like improved nutrition, often can treat Hashimoto's disease without medication when thyroid-stimulating hormones (TSH) levels are normal. Synthetic levothyroxine is standard treatment for Hashimoto's when TSH is not normal.
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JAMA Network
jamanetwork.com › jama network › subclinical hypothyroidism
Subclinical Hypothyroidism | Endocrinology | JAMA | JAMA Network
July 9, 2019 - This JAMA Patient Page describes subclinical hypothyroidism and its causes, symptoms, and treatment.
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Healthline
healthline.com › health › hypothryroidism › hashimotos-vs-hypothyroidism
Hashimoto's vs. Hypothyroidism: What's the Difference?
August 9, 2023 - Fluctuating thyroid hormones: Some individuals with Hashimoto’s thyroiditis may experience fluctuating thyroid hormone levels, leading to periods of hyperthyroidism before eventually progressing to hypothyroidism. Non-specific symptoms: Symptoms of Hashimoto’s thyroiditis, like fatigue, weight gain, and hair loss, can be vague and similar to other health issues, leading to misdiagnosis or delayed identification of the underlying cause. Symptom overlap: Hashimoto’s thyroiditis can share symptoms with other thyroid disorders or autoimmune diseases, making it challenging to differentiate without proper testing.
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC9821760
Hashimoto Thyroiditis, but Not Hypothyroidism Due to Other Causes, Is Associated with Lower Phase Angle Score in Adult Women: A Pilot Cross-Sectional Study - PMC
Conclusions: Decreased PhA scores in patients with HT may indicate that the inflammatory process in this autoimmune disease has an influence on cellular health and on the function of the entire body. Such an association was not found in women with non-HT hypothyroidism. Keywords: Hashimoto’s thyroiditis, hypothyroidism, inflammation, bioimpedance analysis, phase angle
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Everyday Health
everydayhealth.com › health conditions › thyroid disease › hypothyroidism
10 Common Causes of Hypothyroidism You Need to Know
October 5, 2022 - Hashimoto’s thyroiditis isn’t the only risk factor for an underactive thyroid. There are 10 well-studied causes of the disease, including pregnancy, thyroid surgery, and certain medications. Here’s what to know. ... Hypothyroidism, when your thyroid gland is underactive, develops when ...
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Thyroid Cancer
thyroidcancer.com › blog › graves-disease-vs-hashimoto-s-disease-top-4-things-to-know
Graves’ Disease vs. Hashimoto’s Disease
Both are caused by dysfunction of the immune system (autoimmune condition), but each is different in numerous ways. Graves’ is the most common cause of hyperthyroidism (too much thyroid hormone) in most countries, while Hashimoto’s disease is by far the most common cause of hypothyroidism (too little thyroid hormone production).
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC3565903
Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two brothers - PMC
Subclinical hypothyroidism (SH) is a biochemical condition characterized by serum levels of TSH above the statistically defined upper limit of reference range, with normal concentrations of thyroid hormones and without severe clinical features of hypothyroidism [1]. The prevalence has been ...