Euthyroid hyperthyroxinemia is defined as a condition in which the serum total thyroxine (T4) and triiodothyronine (T3) concentrations are increased, but the thyroid-stimulating hormone (TSH) concentration is normal and there are no clinical signs or symptoms of thyroid dysfunction.

A normal Total T4 level in adults ranges from 5.0 to 12.0μg/dL. A normal Total T3 level in adults ranges from 80-220 ng/dL. Free T3 assays are often unreliable and not routinely used to assess thyroid function.

September 4, 2025 - Subclinical hypothyroidism happens when you have elevated thyroid-stimulating hormone (TSH) levels with normal levels of the hormone thyroxine (T4).

For example, both fractionated ... TH levels. Interestingly, such changes are not generally associated with clinical thyrotoxicosis, and TSH is usually normal....

A mildly elevated thyroid stimulating hormone (TSH – also called thyrotropin) concentration is the most common thyroid function test abnormality encountered in everyday practice. Most patients who have a mildly elevated TSH have a normal free thyroxine (T4) level.

February 15, 2024 - Subclinical hypothyroidism characteristically presents with normal thyroxine (T4) levels and elevated thyroid stimulating hormone (TSH) levels. The incidence of subclinical hypothyroidism is estimated at 3% to 15%, depending on the population studied. Minor fluctuations in T4 levels result ...

Elevated free T4 with normal TSH is relatively uncommon but can occur in specific clinical scenarios. A study conducted in the Netherlands found that 3.34% of patients had this combination, with 12.3% showing increased free T4 .

February 15, 1998 - Its very sensitivity, however, may create a dilemma, since some patients are found to have elevated serum TSH levels, suggesting hypothyroidism, but have normal levels of thyroid hormone, whether measured as free thyroxine (T4) or free T4 index.

December 18, 2023 - A thyroid function test measures levels of thyroid-stimulating hormone (TSH) and thyroxine (T4) in the blood. This is also called “free” T4. Generally, high TSH can indicate hypothyroidism, while low TSH can indicate hyperthyroidism, though ...

June 8, 2020 - Estrogens, such as in birth control pills, or in pregnancy, cause high levels of total T4 and T3. This is because estrogens increase the level of the binding proteins. In these situations, it is better to ask both for TSH and free T4 for thyroid evaluation, which will typically be in the normal range.

September 30, 2021 - Your free T4 level is normal, meaning ... hormone) level that is above the normal range, which indicates your thyroid gland has to work harder to pump out that thyroid hormone....

May 15, 2000 - When thyroid hormone levels are low, more TSH is produced to stimulate production. When levels are normal, the pituitary gland stops producing TSH. The TSH test measures how much or how little TSH there is in the bloodstream. Thyroxine (T4) is one of two hormones produced by the thyroid gland.

TSH tells your thyroid how much hormone to make. Normally, if your T4 levels are too low, your pituitary makes more TSH to make your thyroid work harder. If your T4 levels are too high, your pituitary stops ...

July 21, 2025 - This is a lack of T4 production due to an issue with your thyroid that’s causing your pituitary gland to release excess TSH to try to stimulate your thyroid into making more T4. Having high TSH and high T4 levels may indicate that you have an issue with your pituitary gland that’s causing it to release too much TSH, and thus triggering your thyroid to make excess T4.

4 weeks ago - So this early rise in TSH can be used as a sensitive marker for early thyroid GLAND dysfunction. By the way, you may find that both your free T3 and free T4 stay “normal” despite having a very high TSH.

Laboratories are permitted to substitute free hormone assays when total T3 or T4 have been ordered. Measurement of fT3 is rarely indicated in suspected thyroid disease6, 13. This is reserved for situations where thyroid disease is suspected clinically and TSH is abnormal, but fT4 is inappropriately normal.

These studies suggest that very high TSH but normal T3 and T4 levels can be due to factors such as macro-TSH complex, inadequate L-T4 therapy, pituitary alterations, or partial peripheral resistance to thyroid hormone action.

February 23, 2024 - For female patients above the age of 70 who had a free T4 value above the 85th percentile of the normal range, their absolute risk of death and having heart disease was greater than 5%. For male patients above the age of 70 who had a free T4 ...

TSH levels between 0.45 and 4.5 mU/L indicate normal thyroid function. TSH levels under 0.45 mU/L suggest hyperthyroidism, which is overactive thyroid, or overtreated hypothyroidism. ... If TSH levels appear abnormal, your provider may order a free T4 test. Low levels of T4 suggest hypothyroidism.