New England Journal of Medicine
nejm.org › doi › full › 10.1056 › NEJMoa040079
Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism | New England Journal of Medicine
Given the importance of maternal euthyroidism for normal fetal cognitive development, we propose that women with hypothyroidism increase their levothyroxine dose by approximately 30 percent as soon as pregnancy is confirmed.
American Thyroid Association
thyroid.org › home › patients portal › clinical thyroidology for the public › october 2016 › vol 9 issue 10 p.5-6
Increasing levothyroxine doses early in pregnancy is associated with a lower risk for pregnancy loss in hypothyroid women
October 9, 2016 - Many endocrinologists advise pregnant women to take a higher dose of Levothyroxine as soon as pregnancy is confirmed and to come in to have blood tests for TSH more often to ensure that the level remains normal. This study was done to evaluate the effect of increasing Levothyroxine dose in preventing pregnancy loss in women with hypothyroidism.
PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC4873573
Levothyroxine Dosage Requirement During Pregnancy in Well-Controlled Hypothyroid Women: A Longitudinal Study - PMC
Of the 81 pregnancies studied, the pregnancy outcomes were 74 full-term births, six abortions and one pre-term birth. The levothyroxine dosage needed to be increased in 84% (CI95%= 74-90) of the pregnancies (OR=5.2, CI95%= 2.9-9.4). Most levothyroxine dose adjustments were made in the first ...
PubMed
pubmed.ncbi.nlm.nih.gov › 15254282
Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism - PubMed
July 15, 2004 - Given the importance of maternal euthyroidism for normal fetal cognitive development, we propose that women with hypothyroidism increase their levothyroxine dose by approximately 30 percent as soon as pregnancy is confirmed …
PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC8900377
Levothyroxine dosages during pregnancy among hypothyroid women. An experience from a tertiary care center of Karachi, Pakistan, based on data from Maternal Hypothyroidism on Pregnancy Outcomes Study (MHPO-5) - PMC
To the best of our knowledge, we ... were reviewed. The median LT4 dosages prescribed before conception was 85.7 mcg per day which increased by 14.3 mcg per day in the first trimester (P 0.001)....
American Thyroid Association
thyroid.org › home › thyroid health – management of hypothyroidism during pregnancy: when and how to treat?
Thyroid Health Blog - Management of Hypothyroidism During Pregnancy: When and how to treat?
March 3, 2024 - Levothyroxine dose should be adjusted to target a TSH level between the lower limit of the reference range and 2.5 mU/L. The patient may be advised to increase the dose of levothyroxine by 20 to 30 % as soon as pregnancy is confirmed to avoid ...
Harvard Gazette
news.harvard.edu › gazette › story › 2004 › 07 › increased-dosage-of-thyroid-medication-necessary-early-in-pregnancy
Increased dosage of thyroid medication necessary early in pregnancy — Harvard Gazette
July 22, 2004 - The researchers found that 85 percent of pregnancies required a nearly 50 percent increase in the dosage of levothyroxine, and this occurred almost exclusively during the first trimester of the pregnancy.
GoodRx
goodrx.com › goodrx health › drugs › levothyroxine › levothyroxine and pregnancy: what you need to know
Levothyroxine and Pregnancy: What You Need to Know - GoodRx
March 23, 2022 - Your healthcare provider may adjust your levothyroxine dose during and after pregnancy. ... morning sickness — are very obvious to the pregnant person. But other changes may not be so obvious. In pregnancy, your body adapts to accommodate your growing baby.
New England Journal of Medicine
nejm.org › doi › full › 10.1056 › NEJMe048110
Increased Levothyroxine Requirements in Pregnancy — Why, When, and How Much? | New England Journal of Medicine
The development of sensitive assays for measuring thyrotropin has led to a reduction in levothyroxine doses; in most patients, a dose of only 100 to 125 μg daily restores serum thyrotropin levels to the reference range, thereby satisfying the ...
Healio
healio.com › news › endocrinology › 20201209 › levothyroxine-overtreatment-during-pregnancy-increases-odds-for-preterm-delivery
Levothyroxine overtreatment during pregnancy increases odds for preterm delivery
December 9, 2020 - Of 9,869 women included in analysis ... timing for first adjustment during weeks 5 and 6 of gestation. Levothyroxine dosage increased as pregnancy progressed....
Ugeskriftet
ugeskriftet.dk › dmj › dose-levothyroxine-pregnant-women-hypothyroidism-should-be-increased-20-30-first-trimester
The dose of levothyroxine in pregnant women with hypothyroidism should be increased by 20-30% in the first trimester | Ugeskriftet.dk
The foetus is entirely dependent ... [6]. The increase of the L-T4 dosage is usually 30% in the first trimester, and there is an average increase of 48% by 16-20 weeks [7]....
GPnotebook
gpnotebook.com › home › pages › general information › pregnancy (hypothyroidism during)
Pregnancy (hypothyroidism during): Management of hypothyroidism during pregnancy – GPnotebook
June 29, 2021 - an alternative approach is to advise the woman to increase the dose of levothyroxine by 30%-50% as soon as pregnancy is confirmed to avoid any delay in dose increment (1)
Reddit
reddit.com › r/pregnant › hypothyroid ladies: how often did you get your thyroid hormone medication adjusted in pregnancy?
r/pregnant on Reddit: Hypothyroid ladies: How often did you get your thyroid hormone medication adjusted in pregnancy?
January 7, 2024 -
If you’re on thyroid hormone during pregnancy (levothyroxine) — how often was your dose increased during pregnancy?
Background: working with an endocrinologist for monitoring (labs every 2 weeks). 17 weeks pregnant, and my levothyroxine dose has increased every month. Went from 12.5mcg to now 88mcg…. Seems like my TSH levels will be stable (2-3) for about a month before creeping high (3-5) again, and my dose having to be increased.
I have Hashimotos, but did not need to medicate pre-pregnancy because my TSH was usually 4-6 but with no symptoms. About 5 months before getting pregnant went on 12.5-25mcg levothyroxine and that made me HYPERthyroid (TSH <0.45!).
These constant increases have me kind of confused, and trying to understand if I should be pushing my endocrinologist for more answers (vs her just increasing my dose every 2-4 weeks).
Top answer 1 of 6
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I have extreme hypothyroidism, and have my entire life. I would have to go to my primary every 3 months to get my TSH & T4 checked. When I got pregnant, I was already on 125mcg and checked my levels with my OB at my first prenatal appt which was 9 weeks and they were 2.4. My OB wants me between 0.4 and 2.5 during pregnancy, so I stayed on that same 125mcg script I had pre pregnancy for awhile. Having thyroid issues my whole life, I can tell when it’s not where it should be and at 17 weeks I had her check it again. I was right, and it had jumped up to 3.3 so she increased my levothyroxine by 25% and I now take an 25mcg pill in addition to my 125mcg every morning totaling 150mcg. I am now currently 25 weeks and just got my levels checked again at my appointment last week, and I was sitting at a 1.7, so am still taking 150mcg daily! For me, it’s more so she tests me whenever I request it but again I have been dealing with this and having symptoms of it my entire life so I know my body enough, but it’s not something they have ever checked without me asking. Pregnancy hormones can really mess with your thyroid and even someone with no prior thyroid issues could end up needing to supplement during pregnancy just due to the changes in our body! As long as you’re being tested often and increased as needed I wouldn’t worry too much.
PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC6532810
Thyroid hormone replacement in the preconception period and pregnancy - PMC
On conception, levothyroxine dose should be increased to mirror the post-conception increase in thyroid hormone requirements.1 A rule of thumb is to increase levothyroxine dose by 25 mcg daily in women receiving doses of ≤100 mcg, and by 50 mcg daily in women receiving >100 mcg daily.2,5 ...
UHS Sussex
uhsussex.nhs.uk › wp-content › uploads › 2022 › 08 › Pregnancy-and-hypothyroidism.pdf pdf
Pregnancy and hypothyroidism Department of Endocrinology Patient information
Hypothyroidism is treated with thyroxine (also called levothyroxine), which is a synthetic (man-made) form of the natural ‘T4’ hormone · produced by the thyroid gland. Thyroxine is safe to take whilst · pregnant and whilst breast-feeding. Thyroxine should be taken ·
New England Journal of Medicine
nejm.org › doi › abs › 10.1056 › NEJMoa040079
Timing and Magnitude of Increases in Levothyroxine ...
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
ScienceDirect
sciencedirect.com › science › article › pii › S1028455923002450
Effect of extra-low dose levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism undergoing in vitro fertilization and embryo transfer - ScienceDirect
November 25, 2023 - SCH is defined as normal serum free thyroxine (T4) level and an elevated serum thyroid stimulating hormone (TSH) level >4 mIU/L. Extra-low dose of levothyroxine (LT4; 25 mcg/day) was prescribed to the SCH women from the establish of diagnosis ...
Oxford Academic
academic.oup.com › jcem › article › 95 › 7 › 3234 › 2596283
Thyroid Hormone Early Adjustment in Pregnancy (The THERAPY) Trial ...
July 1, 2010 - Increasing the l-T4 dose once pregnant (regardless of study arm) prevented TSH elevation over 5.0 mIU/liter throughout the first trimester and replicated physiological changes of pregnancy.
American Thyroid Association
thyroid.org › home › patients portal › clinical thyroidology for the public › vol 7 issue 2 › vol 7 issue 2 p.3
How much levothyroxine should be started for hypothyroidism diagnosed during pregnancy?
January 30, 2014 - This is an important study as it provides recommendations for the selection of an initial levothyroxine dose in women with hypothyroidism diagnosed during pregnancy. This guidance is important in decreasing the risks of untreated hypothyroidism, which during pregnancy can result in poor outcomes to the mother and baby.
