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Mayo Clinic
mayoclinic.org › diseases-conditions › hypothyroidism › symptoms-causes › syc-20350284
Hypothyroidism (underactive thyroid) - Symptoms and causes - Mayo Clinic
December 10, 2022 - Understand what happens when your thyroid is underactive and learn about treatment for this condition.
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NHS
nhs.uk › conditions › underactive-thyroid-hypothyroidism
Underactive thyroid (hypothyroidism) - NHS
An underactive thyroid (hypothyroidism) is a common condition where the thyroid gland in your neck does not make enough hormones. This can cause symptoms like tiredness and weight gain.
Discussions

Husband's symptoms may be side effects of Synthroid
I'm guessing your husband may be undermedicated. Has he been tested for Graves' disease? Ask for a TSH Receptor antibody test (TRab). Insist on a FT4 and FT3, and not just TSH, especially because he is so symptomatic. Graves' antibodies affect the TSH, so TSH is not the best dosing guideline if those antibodies are present. Feeling cold and constipated are classic hypo symptoms that sometimes resolve on a higher dose of meds. More on reddit.com
🌐 r/Hypothyroidism
25
4
June 21, 2021
Can you have symptoms at TSH level 2.2 or is it in my head?
Yes you can have symptoms. No it's not in your head & don't let anyone say that to you. Fire that doctor & find a new one! Good luck. More on reddit.com
🌐 r/Hypothyroidism
21
14
February 7, 2018
Hyper symptoms from overmedication?

Are you in your late 30s? Is it possible you’re maybe hitting perimenopause? If your estrogen levels drop, you may need to reduce your meds. I found that out the hard way. My levels had been stable for years, then all of a sudden it seems I was overmedicated, but when I looked back over the last year, I could see where I had been having some issues, but I just though it was all the pandemic stuff. But then I started losing weight and losing hair, and found out I was overmedicated at my annual Endo appointment. A few months later my GP tested FSH and LH, which were very high, so menopausal, which would explain some of what happened.

If a person goes on HRT/MHT and raises their estrogen levels, they may have to up their thyroid meds again.

More on reddit.com
🌐 r/Hypothyroidism
15
2
January 3, 2019
TSH 4.5 - MD says this value can't cause symptoms

I would get a second opinion. Some people with "subclinical hypothyroidism" feel totally fine and others feel terrible. The dividing line between subclinical hypothyroidism and hypothyroidism is fairly contentious - even within the medical community. Traditionally, a TSH between 5 & 10 was considered subclinical hypothyroidism and you wouldn't be treated unless you were trying to get pregnant regardless of symptoms. In some places (like the UK), this is still the standard. In the US, it really depends on your medical provider. For example, my endo will treat anyone automatically if their TSH is above 7 and she'll treat people with a TSH between 5 & 7 on a case by case basis (mostly depends on symptoms, comorbidities, and family history).

My TSH was barely out of range (just above 4.5) when my cholesterol skyrocketed. It took another year for my TSH to go above 10. My GP didn't have any really good advice for dealing with cholesterol because all of her diet suggestions were things I wasn't eating. I have celiac so I'm not eating fast food (deep fried breaded things, etc) or a bunch of other things on her list because I'm gluten free. My GP even acknowledged that the standard suggestions didn't make sense. I basically didn't eat eggs for a year as that was the main food on the list that was in my diet. It had zero impact.

Over the course of a year, I also developed fatigue as my other main symptom and assumed I had gluten cross contamination I hadn't identified since fatigue is one of my celiac symptoms. I was super surprised by the hypothyroidism (caused by Hashimoto's). It took about 8 months of thyroid treatment for my cholesterol to come down - my cholesterol is still a touch too high but my doctor thinks upping my veg/fruit (via like a daily smoothie) will be enough. Diet changes alone had no impact and since my cholesterol has come down so much, my doctor is no longer considering statins.

More on reddit.com
🌐 r/Hypothyroidism
7
2
May 16, 2020
People also ask

What are the common symptoms of thyroid issues?
The symptoms depend on whether the thyroid is overactive (hyperthyroidism) or underactive (hypothyroidism). Hyperthyroidism symptoms include anxiety, tremors, irregular heartbeat, heat intolerance, and weight loss. Hypothyroidism symptoms include lethargy, constipation, hair thinning, bloating, cold intolerance, and dry skin. Excessive fatigue can be a symptom of both conditions.
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mdanderson.org
mdanderson.org › cancerwise › 2023 › 10 › signs of thyroid issues: how do you know if you have them?
Signs of thyroid issues: How do you know if you have them? | MD ...
How do thyroid hormones affect heart function?
Thyroid hormones have a strong connection to heart function. Too much thyroid hormone can increase the risk of a rapid or irregular heartbeat (tachycardia and atrial fibrillation). Too little thyroid hormone can lead to a low heart rate (bradycardia) and an enlarged heart (cardiomyopathy). These heart conditions can also be a sign that a person has an undiagnosed thyroid problem.
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mdanderson.org
mdanderson.org › cancerwise › 2023 › 10 › signs of thyroid issues: how do you know if you have them?
Signs of thyroid issues: How do you know if you have them? | MD ...
Can cancer treatment affect thyroid function?
Yes, some cancer treatments can affect the thyroid gland. Radiation therapy to the head or neck area, certain immunotherapy, targeted therapy, and chemotherapy drugs can cause thyroid dysfunction. It's important for patients to report all symptoms to their cancer care team so that blood tests can be done and any thyroid issues can be addressed promptly.
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mdanderson.org
mdanderson.org › cancerwise › 2023 › 10 › signs of thyroid issues: how do you know if you have them?
Signs of thyroid issues: How do you know if you have them? | MD ...
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Liv Hospital
int.livhospital.com › home › clinics › endocrinology › hypothyroidism › symptoms and hormonal
Symptoms and Hormonal - Liv Hospital
2 days ago - When levels are low, your body produces less heat, making you feel cold even in comfortable temperatures. ... Yes, muscle and joint pain, stiffness, and weakness are common symptoms.
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MedlinePlus
medlineplus.gov › home › health topics
Hypothyroidism | Hashimoto's Disease | MedlinePlus
Because hypothyroidism develops slowly, many people don't notice symptoms of the disease for months or even years.
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NIDDK
niddk.nih.gov › home › health information › endocrine diseases › hypothyroidism (underactive thyroid)
Hypothyroidism (Underactive Thyroid) - NIDDK
October 3, 2025 - Many of these symptoms, especially fatigue and weight gain, are common and do not necessarily mean you have a thyroid problem. ... Less often, hypothyroidism is caused by too much or too little iodine in the diet or by disorders of the pituitary gland or hypothalamus.1 Iodine deficiency, however, is extremely rare in the United States.
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Johns Hopkins Medicine
hopkinsmedicine.org › health › conditions-and-diseases › hypothyroidism
Hypothyroidism | Johns Hopkins Medicine
Hypothyroidism means your thyroid gland is underactive. It isn’t making enough thyroid hormone. The most common cause is when your immune system starts to attack itself. Symptoms include dull facial expressions, tiredness, and weight gain.
Find elsewhere
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HealthLink BC
healthlinkbc.ca › healthwise › hypothyroidism
Hypothyroidism | HealthLink BC
Worldwide, iodine deficiency is the number one cause of hypothyroidism. If you have low thyroid levels, you may feel tired, weak, or depressed. Other symptoms include dry skin, brittle nails, not being able to stand the cold, constipation, memory problems, and heavy or irregular menstrual periods.
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Merck Manual
merckmanuals.com › home › hormonal and metabolic disorders › thyroid gland disorders › hypothyroidism
Hypothyroidism - Hormonal and Metabolic Disorders - Merck Manual Consumer Version
March 11, 2024 - Doctors usually suspect hypothyroidism on the basis of the symptoms and findings on physical examination, including a slow pulse.
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American Thyroid Association
thyroid.org › home › hypothyroidism
Hypothyroidism | American Thyroid Association
September 10, 2015 - If you feel these symptoms, tell your doctor. You may need to change your dose. Your doctor will check your blood 6 to 8 weeks after starting or changing your thyroid hormone dose. If you’re pregnant or take other medicines, you may need more frequent checks. Babies with hypothyroidism need ...
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KidsHealth
kidshealth.org › en › parents › hypothyroidism.html
Hypothyroidism and Hashimoto’s Thyroiditis | Nemours KidsHealth
A person with mild hypothyroidism may feel just fine. In fact, it might cause no symptoms at all.
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MyHealth Alberta
myhealth.alberta.ca › Health › pages › conditions.aspx
Hypothyroidism
If you have low thyroid levels, you may feel tired, weak, or depressed. Other symptoms include dry skin, brittle nails, not being able to stand the cold, constipation, memory problems, and heavy or irregular menstrual periods.
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Penn Medicine
pennmedicine.org › home › conditions we treat › hypothyroidism
Hypothyroidism – Symptoms and Causes | Penn Medicine
1 month ago - Hypothyroidism, also called an ... in your body use energy. When you don’t have enough of the hormones, you’ll experience symptoms like fatigue and weight gain....
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Medical News Today
medicalnewstoday.com › articles › 324535
Symptoms of Hypothyroidism (underactive thyroid)
May 2, 2025 - Hypothyroidism, or an underactive thyroid, is when the thyroid gland produces too few hormones. Low thyroid hormone levels can cause a range of signs and symptoms, from changes in mental functioning to digestive issues.

human disease

Molecular structure of the thyroxine molecule
Hypothyroidism
Hypothyroidism is an endocrine disease in which the thyroid gland does not produce enough thyroid hormones. It can cause a number of symptoms, such as poor ability to tolerate cold, extreme fatigue, … Wikipedia
Factsheet
Hypothyroidism Molecular structure of thyroxine, which is deficient in hypothyroidism
Specialty Endocrinology
Factsheet
Hypothyroidism Molecular structure of thyroxine, which is deficient in hypothyroidism
Specialty Endocrinology
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Wikipedia
en.wikipedia.org › wiki › Hypothyroidism
Hypothyroidism - Wikipedia
13 hours ago - Hypothyroidism is an endocrine ... a number of symptoms, such as poor ability to tolerate cold, extreme fatigue, muscle aches, constipation, slow heart rate, depression, and weight gain....
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KidsHealth
kidshealth.org › en › parents › congenital-hypothyroidism.html
Congenital Hypothyroidism | Nemours KidsHealth
Hypothyroidism (or underactive thyroid) is when the thyroid gland doesn't make enough thyroid hormone.
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Harvard Health
health.harvard.edu › diseases-and-conditions › hypothyroidism-symptoms-and-signs-in-an-older-person
Hypothyroidism symptoms and signs in an older person - Harvard Health
January 9, 2025 - Reduced blood volume, weaker contractions of the heart muscle, and a slower heart rate—all caused by low thyroid hormone levels—can contribute to heart failure, when your heart can't pump out blood as effectively as it should The ineffective pumping may cause subtle symptoms such as feeling less energetic or just walking more slowly. In more advanced stages, fluid can back up in the lungs and legs causing shortness of breath and leg swelling. Bowel movement changes. An older person with hypothyroidism might have constipation because stool moves more slowly through the bowels.
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NHS inform
nhsinform.scot › home › illnesses and conditions › glands › underactive thyroid
Underactive thyroid symptoms and treatments
February 10, 2025 - It’s very important that an underactive thyroid (hypothyroidism) is diagnosed as soon as possible. Low levels of thyroid-producing hormones, such as triiodothyronine (T3) and thyroxine (T4), can change the way the body processes fat. This can cause high cholesterol and atherosclerosis (clogging of the arteries), which can potentially lead to serious heart-related problems, such as angina and heart attack. Therefore, you should see your GP and ask for a blood test if you repeatedly have symptoms of an underactive thyroid.
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American Academy of Family Physicians
aafp.org › pubs › afp › issues › 2021 › 0515 › p605.html
Hypothyroidism: Diagnosis and Treatment | AAFP
May 15, 2021 - Clinical hypothyroidism affects ... (myxedema coma); more common symptoms include cold intolerance, fatigue, weight gain, dry skin, constipation, and voice changes....