I'm disappointed that nobody in the other answers interpreted "best way" as "fastest way"...

I pulled the 2 examples from here and added str.join() and str.reduce() from nishanths's answer above. Here are my results on Firefox 77.0.1 on Linux.

Note: I discovered while testing these that if I place str = str.concat() and str += directly before or after each other, the second one always performs a fair bit better... So I ran these tests individually and commented the others out for the results...

Even still, they varied widely in speed if I reran them, so I measured 3 times for each.

1 character at a time:

• str = str.concat(): 841, 439, 956 ms / 1e7 concat()'s
• ............str +=: 949, 1130, 664 ms / 1e7 +='s
• .........[].join(): 3350, 2911, 3522 ms / 1e7 characters in []
• .......[].reduce(): 3954, 4228, 4547 ms / 1e7 characters in []

26 character string at a time:

• str = str.concat(): 444, 744, 479 ms / 1e7 concat()'s
• ............str +=: 1037, 473, 875 ms / 1e7 +='s
• .........[].join(): 2693, 3394, 3457 ms / 1e7 strings in []
• .......[].reduce(): 2782, 2770, 4520 ms / 1e7 strings in []

So, regardless of whether appending 1 character at a time or a string of 26 at a time:

• Clear winner: basically a tie between str = str.concat() and str +=
• Clear loser: [].reduce(), followed by [].join()

My code, easy to run in a browser console:

{
  console.clear();

  let concatMe = 'a';
  //let concatMe = 'abcdefghijklmnopqrstuvwxyz';

  //[].join()
  {
    s = performance.now();
    let str = '', sArr = [];
    for (let i = 1e7; i > 0; --i) {
      sArr[i] = concatMe;
    }
    str = sArr.join('');
    e = performance.now();
    console.log(e - s);
    console.log('[].join(): ' + str);
  }

  //str +=
  {
    s = performance.now();
    let str = '';
    for (let i = 1e7; i > 0; --i) {
      str += concatMe;
    }
    e = performance.now();
    console.log(e - s);
    console.log('str +=: ' + str);
  }

  //[].reduce()
  {
    s = performance.now();
    let str = '', sArr = [];
    for (let i = 1e7; i > 0; --i) {
      sArr[i] = concatMe;
    }
    str = sArr.reduce(function(pre, next) {
      return pre + next;
    });
    e = performance.now();
    console.log(e - s);
    console.log('[].reduce(): ' + str);
  }

  //str = str.concat()
  {
    s = performance.now();
    let str = '';
    for (let i = 1e7; i > 0; --i) {
      str = str.concat(concatMe);
    }
    e = performance.now();
    console.log(e - s);
    console.log('str = str.concat(): ' + str);
  }

  'Done';
}