It is possible to interact with DOM from pyscript - see this answer.

However, all documentation, tutorials, books and online courses are for vanilla JavaScript. Pyscript is still a niche. Nobody is going to help you. If you do not have strong background in web development, it is likely to be easier for you to learn JavaScript in the first place and follow the common guides.

Answer from Mikko Ohtamaa on Stack Overflow
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Towards Data Science
towardsdatascience.com › home › latest › pyscript vs. javascript: a battle of web titans
PyScript vs. JavaScript: A Battle of Web Titans | Towards Data Science
June 13, 2025 - JavaScript has been the king of web development for decades. It’s everywhere: from simple button clicks to complex web apps like Gmail and Netflix. But now, there’s a challenger stepping into the ring—PyScript—a framework that lets you run Python in the browser without needing a backend.Sounds like a dream, right?
Discussions

Pyscript vs JS
Would be a dream, but can more see rust replace JS tbh Python's WASM interest isn't that high unfortunately, would be great to get Python as the language of the web More on reddit.com
🌐 r/PyScript
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June 15, 2024
Will pyscript replace JavaScript?
I don't think so, no. JavaScript is an entrenched language, natively supported in the browser, with a wealth of frameworks and libraries. Heck, one of the reasons that PyScript is already so compelling to use is how easily it interacts with some of these JavaScript libraries. So it's not an either/or proposition: JavaScript, PyScript, and other WebAssembly-powered languages can coexist and interoperate, to everyone's benefit. More on reddit.com
🌐 r/PyScript
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May 4, 2022
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DEV Community
dev.to › kristiyanvelkov › pyscript-vs-javascript-1pph
PyScript vs JavaScript - DEV Community
June 15, 2023 - C# - Blazor Use the power of .NET and C# to build full stack web apps without writing a line of JavaScript. Python - PyScript PyScript that allows you to use Python on the web using standard HTML.
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Quora
quora.com › Is-PyScript-faster-than-JavaScript
Is PyScript faster than JavaScript? - Quora
Answer: No, it is not. The comparison is not logical Pyscript is written in Typescript with Tailspin CSS giving it the style. So in a way, pyscript cannot be said as different language.
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DEV Community
dev.to › kristiyanvelkov › pyscript-vs-javascript-1pph › comments
[Discussion] PyScript vs JavaScript — DEV Community
June 13, 2023 - Sure some languages are absolutely no brainer in terms of earnings and future stability in that sense, but us developers, the true computer scientists at heart, we like to linger in the domain of fine learning. And that's what it is, pyscript, it's an avenue to the future. Maybe not implemented as a direct alternative to javascript, but in some other shape or form.
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Medium
medium.com › the-future-machine-learning-and-ai › dont-love-javascript-pyscript-is-bringing-python-to-your-browser-81e616ac1123
Don’t Love JavaScript? PyScript is Bringing Python To Your Browser! | by M Mahfujur Rahman, PhD | Machine Learning and Deep Learning | Medium
May 12, 2022 - PyScript is developed by the team from Anaconda, which includes Peter Wang, Fabio Pliger, and Philipp Rudiger. It’s a JavaScript framework that lets you mix Python with HTML.
Find elsewhere
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DEV Community
dev.to › devsmitra › what-is-pyscript-and-why-should-you-care-10f
What is PyScript? And Why Should You Care? - DEV Community
December 10, 2022 - PyScript is a python script that can be run in the browser using a mix of Python and standard HTML.... Tagged with javascript, python, html, webdev.
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Quora
quora.com › Is-PyScript-better-than-JavaScript-What-are-the-pros-and-cons
Is PyScript better than JavaScript? What are the pros and cons? - Quora
Choose by matching strengths to your priorities: developer familiarity and rapid data-centric prototyping (PyScript) versus performance, ecosystem, and production maturity (JavaScript).
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Real Python
realpython.com › pyscript-python-in-browser
A First Look at PyScript: Python in the Web Browser – Real Python
December 1, 2023 - In other words, PyScript allows you to use Python, with or without JavaScript, to build interactive websites that don’t necessarily have to communicate with a server. The main benefit here is that you can leverage your existing knowledge of Python to enter the world of front-end development, lowering the entry barrier and making it more accessible.
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freeCodeCamp
freecodecamp.org › news › pyscript-python-front-end-framework
How to Use PyScript – A Python Frontend Framework
May 12, 2025 - PyScript isn't meant to take the role of JavaScript in the browser, though – rather, it's meant to give Python developers, particularly data scientists, more flexibility and power.
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freeCodeCamp
freecodecamp.org › news › python-vs-javascript-what-are-the-key-differences-between-the-two-popular-programming-languages
Python VS JavaScript – What are the Key Differences Between The Two Popular Programming Languages?
January 28, 2021 - While Python can be used to develop the back-end part of a web application, JavaScript can be used to develop both the back-end and the front-end of the application.
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Quora
quora.com › Has-there-been-any-benchmark-done-to-test-pyscript-versus-JavaScript-Is-pyscript-built-on-top-of-cpython-more-or-less-performant-than-JavaScript-What-are-some-performance-advantages-or-disadvantages-on-both
Has there been any benchmark done to test pyscript versus JavaScript? Is pyscript built on top of cpython more or less performant than JavaScript? What are some performance advantages or disadvantages on both? - Quora
Answer (1 of 2): Pyscript can’t replace JS. It will be useful to construct web apps for DS and ML people. Pyscript can do some amazing things. Python in the browser is certainly a great idea for many Data Scientists who have invested a lot of time and effort in learning the language and the vari...
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Lucent Innovation
lucentinnovation.com › lucent innovation › it insights › python or javascript: which language fits your development needs?
Python vs JavaScript: Which is a better choice?
Software Development & Data Science Company
How: Python controls backend functionality and APIs, while JavaScript handles the user interface. Node.js developers can utilize frameworks like Express.js to build robust server-side applications, seamlessly integrating with Python-powered APIs for full-stack development. ... How: PyScript enables ... Lucent Innovation is a global software solution provider for Digital enterprises, giving seamless web and mobile application development, data science solutions and e-commerce services. We are a leading official Shopify plus partners, Shopify Experts that concepts your idea into the product. Con
Rating: 4.8 ​
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Open Source For You
opensourceforu.com › home › audience › developers › an introduction to pyscript
An Introduction to PyScript - Open Source For You
October 6, 2024 - PyScript doesn’t need to be installed; we only have to import pyscript.js and pyscript.css. If there is no internet access it can be downloaded and used directly in the HTML files. Enable drop-in content, external file hosting, and application hosting without the reliance on server-side configuration. Let’s write a simple ‘Hello World’ Python code in the browser. Python code is enclosed in the custom py-script tag. Like JavaScript, one can have many py-script tags.
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Medium
fico-aditama.medium.com › try-create-chart-using-javascript-vs-pyscript-python-810e6762a29a
Try Create Chart Using Javascript vs Pyscript ( Python ) | by Fiko Aditama | Medium
July 15, 2023 - Learn how to create charts using JavaScript and Python. Find out whether JavaScript or Python is a better choice for your charting needs.
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LIVEcommunity
live.paloaltonetworks.com › t5 › cortex-xsoar-discussions › javascript-vs-python-scripts › td-p › 594322
LIVEcommunity - JavaScript vs Python scripts - LIVEcommunity - 594322
August 21, 2024 - I replicated this video in XSOAR (Python vs JavaScript - side by side comparison - YouTube) and I read some papers which speaks about this theme, and everyone tells that JavaScript is faster than Python by far.
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Quora
quora.com › Will-PyScript-make-JavaScript-a-less-popular-web-programming-language
Will PyScript make JavaScript a less popular web programming language? - Quora
Answer (1 of 3): Absolutely not. No way. Not a snowflake’s chance in Hell. There’s already “better” Python-to-JavaScript compiler called Transcrypt. The good part about it is that it’s intended as a replacement for JavaScript. There are also bad parts. i.e. not compatible with a lot of the Pytho...