Python has powerful built-in types, but Python lists are not mathematical vectors or matrices. You could do this with lists, but it will likely be cumbersome for anything more than trivial operations.

If you find yourself needing vector or matrix arithmetic often, the standard in the field is NumPy, which probably already comes packaged for your operating system the way Python also was.

I share the confusion of others about exactly what it is you're trying to do, but perhaps the numpy.linalg.norm function will help:

>>> import numpy
>>> a = numpy.array([1, 2, 3, 4])
>>> b = numpy.array([2, 3, 4, 5])
>>> numpy.linalg.norm((a - b), ord=1)
4

To show how that's working under the covers:

>>> a
array([1, 2, 3, 4])
>>> b
array([2, 3, 4, 5])
>>> (a - b)
array([-1, -1, -1, -1])
>>> numpy.linalg.norm((a - b))
2.0
>>> numpy.linalg.norm((a - b), ord=1)
4