You could create a python virtual environment on your USB stick using your computer: python -m venv my_venv When you want to install packages on the USB-stick in the virtual environment, activate it, intall your packages and deactivate it afterwards: my_venv\Scripts\activate.bat pip install tkinder pip install pyperclip deactivate Then, on someone else's computer you don't want to change, open a terminal, navigate to your USB-stick and activate your virtual env on your USB-stick: my_venv\Scripts\activate.bat You could even start an IDE from the terminal after activating the virtual-environment and your IDE would see the Python packages as environment variables, search paths have been set. More on reddit.com

repl.it ? More on reddit.com

Yes it is possible you linked to examples. The simple way is to use a simple server and the eval() command. Or use Jupyter is the industry standard for this. More on reddit.com

Well if they are a bit familiar with python, they might copy the content of the file into python source code as string. Then you could use io.StringIO to simulate a file or use string methods instead of file methods. Jdoodle also allows you to kinda work with files, read the note they provide: Note: For file operations - upload files using upload button [icon], Files will be upload to /uploads folder. You can read those files in program from /uploads folder. To write a file from your program, write files to '/myfiles' folder. Please note the uploaded files stored in the server only for the current session. Repl.it is probably the best for both sharing, editing and using custom files as it pretty much is full blown IDE, in your browser, the downside is that you need to make an account to use it and so do any visitors that would run the code. More on reddit.com