Just create the file with QPython before use in your script. You can create an txt file with QPython. In My case I create the file whith name "pontoText.txt" Inside folder "MyPythonScripts" (Im create that folder to put my python files) so the file is in the same folder of the script and are created in QPython Now an example code im make ton test:

import time
import os
a = input("1 to save date on file or 2  too see records on file. ")
folder= '/storage/emulated/0/MyPythonScripts'
if(a == "1"):
    pontoTxt=open(os.path.join(folder,'pontoText.txt'),'w')
    pontoTxt.write(time.strftime("%I %M %p on %A, %B %e, %Y"))
if(a == "2"):
    pontoTxt=open(os.path.join(folder,'pontoText.txt'),'r')
    exibe = pontoTxt.read()
    print(exibe)

There is also the new Android Scripting Environment (ASE/SL4A) project. It looks awesome, and it has some integration with native Android components.

Note: no longer under "active development", but some forks may be.