It may be worth to try this:

Time_Out=Blank()

I have found in some cases that this may be delegated whereas IsBlank() is not.

This is not documented anywhere, PowerApps documentation has a long way to go.

To achieve this you need to do the following two steps:

1. Set the form mode - Whenever you work with the Edit Form component you need to specify in which mode you are going to work. Since you want to add a new record to the list, you need to set the Form Mode as NewForm. You can set OnVisible property of the current screen or OnSelect property of the button (if you are navigating from any other screen) as NewForm(Form1). You can find more ways to do so and more insight over here.

2. To enable or disable the button as per your requirement, set the DisplayMode property of the button as:

If( 
    Or( 
       IsBlank(Field1.Text), 
       IsBlank(Field2.Text),
       IsBlank(Field3.Text), 
       IsBlank(Field4.Text)
      ),
    DisaplayMode.Disabled,
    DisaplayMode.Edit
)

Source: PowerApp DataCardValue.Text Returning as blank when not blank - Thanks to @SumitSingh.

Use IsBlank and Trim to check for any empty or whitespace strings.

IsBlank(Trim(Column2))

Trim will remove any whitespace and IsBlank will return a true/false if the string is empty or not after the trim.

IsBlank

Trim

UPDATE: Check only for IsBlank where Column2 is evaluated, the way you wrote it it's checking if Column2 = bool which will have a type mismatch since it's checking a string vs a bool, change to this:

ClearCollect(Test,LookUp(Table1,Column1=DataCardValue6.Text && IsBlank(Trim(Column2))))