Hi. I have the same problem on two different PCs, one running Windows 10 Enterprise (PrimaLuceLab Eagle4 Pro), and the other running Windows 10 Pro ( ASRock H270M-ITX/ac motherboard). In both cases if I install the Prolific USB-to_Serial Comm Port driver they work just fine. But if I allow Microsoft to install the latest driver it replaces it with a driver that fails every time on both computers. If I then go back and once again install the Prolific USB-to Serial Comm Port driver both computers begin to work just fine once more. I have tried all of the Microsoft troubleshooting suggestions and the Microsoft latest driver never works, but the Prolific driver always works. The funny (and annoying) thing about this is that a few months later I forget about the problem and run Norton 360 Driver Update Utility and the driver issue once again occurs. I then have to retrace my steps, and once again discover that the issue is with the Microsoft driver, find the Prolific driver, and install it once more. Sigh...

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Driver Easy
drivereasy.com › home › knowledge base › driver error › solved: prolific usb to serial driver not working on windows
Solved: Prolific USB to Serial Driver Not Working on Windows - Driver Easy
January 17, 2024 - Double-click Ports(COM & LPT), then right-click on your Prolific USB to Serial driver to select Update driver. Click Browse my computer for driver software. Select Let me pick from a list of available drivers on my computer.
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Hi. I have the same problem on two different PCs, one running Windows 10 Enterprise (PrimaLuceLab Eagle4 Pro), and the other running Windows 10 Pro ( ASRock H270M-ITX/ac motherboard). In both cases if I install the Prolific USB-to_Serial Comm Port driver they work just fine. But if I allow Microsoft to install the latest driver it replaces it with a driver that fails every time on both computers. If I then go back and once again install the Prolific USB-to Serial Comm Port driver both computers begin to work just fine once more. I have tried all of the Microsoft troubleshooting suggestions and the Microsoft latest driver never works, but the Prolific driver always works. The funny (and annoying) thing about this is that a few months later I forget about the problem and run Norton 360 Driver Update Utility and the driver issue once again occurs. I then have to retrace my steps, and once again discover that the issue is with the Microsoft driver, find the Prolific driver, and install it once more. Sigh...

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Hi, here to work with you on this issue.

If Windows is indicating that the USB to serial converter won't start and suggests reloading the driver, but you've already attempted that and it still doesn't work, there are a few troubleshooting steps you can try:

  1. Unplug and reconnect the USB to serial converter: Disconnect the converter from your computer's USB port and wait for a few seconds. Then plug it back in, ensuring it is securely connected. Sometimes, a simple reconnection can resolve connection issues.
  2. Try a different USB port: Connect the USB to serial converter to a different USB port on your computer. It's possible that the current port you're using is experiencing problems, and trying a different one might help.
  3. Restart your computer: Sometimes, a system restart can fix driver-related issues. Restart your computer and see if the USB to serial converter starts working after the reboot.
  4. Update the driver manually: Even if Windows claims the correct driver is installed, there's a possibility that it may be outdated or corrupted. You can try manually updating the driver by following these steps: a. Go to the Device Manager by right-clicking on the Start button and selecting "Device Manager" from the menu. b. In the Device Manager window, locate the USB to serial converter. It might be listed under "Ports (COM & LPT)" or "Universal Serial Bus controllers." c. Right-click on the USB to serial converter and select "Update driver" from the context menu. d. Choose the option to manually search for the driver. You can either provide the specific driver file if you have it or let Windows search online for the latest driver version. e. If Windows finds an updated driver, follow the on-screen instructions to install it. Once the installation is complete, restart your computer and check if the converter starts working.
  5. Contact the manufacturer's support: If none of the above steps resolve the issue, it's recommended to reach out to the manufacturer's support for further assistance. They may provide specific troubleshooting steps or advice tailored to your USB to serial converter model.

Remember to provide as much information as possible when contacting support, such as the make and model of the USB to serial converter and the version of Windows you're using.

I hope this is helpful. If you require any additional assistance, don't hesitate to respond to this.

Regards,

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Bjornsblog
bjornsblog.nl › home › fix: prolific pl2303 windows 10/11
Fix: Prolific PL2303 Windows 10/11 - Björns Blog
March 4, 2024 - You can download working drivers below. They are just the 2008 version of the official driver.
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Ifamilysoftware
ifamilysoftware.com › Prolific_PL-2303_Code_10_Fix.html
Prolific PL-2303 Driver Solution for Code 10 Error
Prolific PL-2303 Code 10 Fix · Copyright 2018, Family Software. All rights reserved
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HP Support Community
h30434.www3.hp.com › t5 › Notebooks-Archive-Read-Only › Need-the-Prolific-USB-to-Serial-Comm-Port-Driver › td-p › 8930213
Need the Prolific USB-to-Serial Comm Port Driver - HP Support Community - 8930213
December 9, 2023 - I need a driver for windows 10 22H2. ... The windows update should have found it. Else try any of these · https://www.prolific.com.tw/US/ShowProduct.aspx?p_id=225&pcid=41
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Quora
recoverit.quora.com › How-to-Fix-Prolific-USB-to-Serial-Driver-not-Working-on-Windows-10
How to Fix Prolific USB to Serial Driver not Working on Windows 10? - Recoverit Data Recovery - Quora
This video is entirely dedicated to users who often connect serial devices to their PC using a prolific USB-to-serial cable. While these cables work fine most of the time, there are a few situations when you might not be able to establish a successful connection between the serial device and your...
Find elsewhere
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GitHub
gist.github.com › phamhieu › d7b6aad785a6e49fa42da32f56ea2099
Prolific USB-to-Serial Fix · GitHub
Prolific USB-to-Serial Fix. GitHub Gist: instantly share code, notes, and snippets.
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Plugable
plugable.com › plugable technologies › usb serial adapter drivers (prolific)
USB Serial Adapter Drivers (Prolific) ~ Plugable Technologies
October 1, 2020 - Download the latest drivers for your Plugable PL2303-DB9 USB Serial Adapter. Please note, these may not be the latest drivers, but they are the ones we recommend. Additional drivers, provided directly by Prolific, can be found on this page .
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Dell
dell.com › home › support home › product support › driver details
Prolific USB to Serial Controller Driver | Driver Details | Dell United Arab Emirates
2. Read the information in the dialog window. 3. Download and install any prerequisites that are identified in the dialog window before proceeding. 4. Click the Install button. 5. Follow the remaining prompts to perform the update. For more downloads go to the Drivers and downloads.
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EEVblog
eevblog.com › forum › microcontrollers › prolific-usb-to-serial-comm-port-driver-windows-10
prolific usb to serial comm port driver windows 10
May 1, 2018 - EEVblog Captcha · We have seen a lot of robot like traffic coming from your IP range, please confirm you're not a robot · This security check has been powered by · CrowdSec
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GitHub
github.com › theAmberLion › Prolific
GitHub - theAmberLion/Prolific: Windows 11 compatible drivers for older Prolific PL2303 USB to RS232 cables (including fake chips) · GitHub
Windows 11 compatible drivers for older Prolific PL2303 USB to RS232 cables (including fake chips) - theAmberLion/Prolific
Starred by 99 users
Forked by 29 users
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FTDI
ftdichip.com › home › drivers
Drivers - FTDI
March 17, 2026 - D3XX drivers are only suitable for FTDI’s Superspeed USB bridge services (e.g. FT60x series). ... FT4222H requires the D2XX drivers and LibFT4222 library for operation (no VCP). ... FT260 and FT602 use built in OS drivers (no need to install any drivers manually). ... When editing driver INF files, refer to the following document:AN_107 Advanced Driver Options. Note that for Windows this breaks driver signing.
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Dell
dell.com › home › support home › product support › driver details
Prolific USB to Serial Controller Driver | Driver Details | Dell US
2. Read the information in the dialog window. 3. Download and install any prerequisites that are identified in the dialog window before proceeding. 4. Click the Install button. 5. Follow the remaining prompts to perform the update. For more downloads go to the Drivers and downloads.
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Driverscape
driverscape.com › download › prolific-usb-to-serial-comm-port
Prolific USB-to-Serial Comm Port Drivers Download for Windows 10, 8.1, 7, Vista, XP
Use the links on this page to download the latest version of Prolific USB-to-Serial Comm Port drivers. All drivers available for download have been scanned by antivirus program.
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Varvayanis
varvayanis.com › miscellaneous › Software & Drivers › Prolific PL2303
Prolific PL2303 USB-to-Serial Comm Port drivers
Latest PL2303 Windows drivers on the Prolific website ... GUID: 618D450A-B26A-4CB2-ABCA-F59C209B312E PL2303GC / GC_Q20 / GS / GT / GT_2AB / GL / GE / GR / GD: ... WDF WHQL Driver: v5.1.9.0 (7/23/2025) Windows 7 / 8.1 / 10 Server 2008 / 2008 R2 / 2012 / 2012 R2 / 2016 / 2019 (32 & 64-bit) PL2303HXD / EA / RA / SA:
Address   185 Fairview Lane, 95370, Sonora
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Ten Forums
tenforums.com › drivers-hardware › 58264-prolific-usb-serial.html
Prolific USB-Serial - Windows 10 Help Forums
August 2, 2016 - If rollback fails you need to reinstall the original driver that came with your USB-Serial port attachment. The problem relates to China imports which are fake chips and were used in many devices sold in recent years. See the warning on the Prolific page and also do a Google search.
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Microsoft
catalog.update.microsoft.com › Search.aspx
Microsoft Update Catalog
We cannot provide a description for this page right now
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Naviter
naviter.com › profilic-usb-serial-driver
Profilic USB-Serial Driver – Naviter.com
First and second generation Flytec varios with integrated GPS (Series 5000 and 6000, Bräuniger IQ Competino / IQ Compeo as well as IQ Basic GPS / IQ Competino+ / IQ Compeo+) use a so-called USB-to-serial interface for their communication with a computer. This requires the installation of a driver on the computer, which is available from the website of Prolific, the developer of USB-to-serial chips: For Microsoft Windows: Prolific PL2303 Windows Driver Download