Sure. Python itself does not include a GUI, but python does have bindings to nearly all GUI libraries. The Windows python installer includes the tkinter GUI library and bindings, so it's probably the most universal. Here's some options in a nutshell: Tkinter: best for super fast development and if you don't want to require your windows users to install extra libraries pyGTK / PyGObject: best for native looking linux programs. You can use Glade to graphically create GUIs. PyQT/ PySide: best for highly custom very pretty interfaces and automatic event linking. Looks native on any OS. You can use QTDesigner to graphically create GUIs. wxPython: Alternative to tkinter for fast and easy interfaces. Has a GTK-like Glade. Kivy: best for multi-touch and small screens - tablets and phones Remi: best for programs that can be accessed via a browser locally or remotely Bokah: best for interactive data display in a browser. The code editor you use has no influence on what you can do with Python. You may also want to ask yourself if your project is better suited for a website / webapp interface. Modules like django and flask (and many others) make it easy to interact with your python program through your browser, either locally or remotely. More on reddit.com

Just create a website in Python using Flask or Django or some other python web framework and then turn it into a Desktop app with Electron. Discord for example uses this method. More on reddit.com

PySimpleGUI is built off Tkinter and is easier to use than Tkinter itself in my opinion. The author has a great documentation site with many examples for many different use cases. He is also active in online forums/GitHub from what I can tell. More on reddit.com

When you start with Python, and programming, you are focused on the very basics working with simple console/terminal based input and output, and everything working step-by-step linearly. When you move to a GUI, you are entering the world of event driven interaction. You can greatly limit the freedom of movement of the user, so you can still step through stages of interaction in the right order, but the way you structure some of your code is very different, and the commands you've learned for input and output change significantly. Sometimes, it will be easiest for you to work on programming problems by developing a simple text solution and then adding a GUI element afterwards when you know the basic logic is working well. There are some problems though that can only be addressed by a GUI. For example, you can learn how to write code to act as a calculator, taking in the numbers and operator using a text interface. You can then improve it and make it look more like a traditional calculator using a GUI. The basic logic will be the same. A common practice in programming is to separate business logic from the user interface. For learning material, RealPython.com have a lot of content that is free to read. Some content will require you to sign up for a free account. (They have a lot more content that is only available to subscribers, I leave you to decide whether that is something you want to spend money on.) They have a great free guide on learning tkinter. Python GUI Programming With Tkinter EDIT: typos More on reddit.com