Python has a keyboard module with many features. Install it, perhaps with this command:

pip3 install keyboard

Then use it in code like:

import keyboard  # using module keyboard
while True:  # making a loop
    try:  # used try so that if user pressed other than the given key error will not be shown
        if keyboard.is_pressed('q'):  # if key 'q' is pressed 
            print('You Pressed A Key!')
            break  # finishing the loop
    except:
        break  # if user pressed a key other than the given key the loop will break

I was searching for a simple solution without window focus. Jayk's answer, pynput, works perfect for me. Here is the example how I use it.

from pynput import keyboard

def on_press(key):
    if key == keyboard.Key.esc:
        return False  # stop listener
    try:
        k = key.char  # single-char keys
    except:
        k = key.name  # other keys
    if k in ['1', '2', 'left', 'right']:  # keys of interest
        # self.keys.append(k)  # store it in global-like variable
        print('Key pressed: ' + k)
        return False  # stop listener; remove this if want more keys

listener = keyboard.Listener(on_press=on_press)
listener.start()  # start to listen on a separate thread
listener.join()  # remove if main thread is polling self.keys

It can be done using ctypes:

import ctypes
from ctypes import wintypes
import time

user32 = ctypes.WinDLL('user32', use_last_error=True)

INPUT_MOUSE    = 0
INPUT_KEYBOARD = 1
INPUT_HARDWARE = 2

KEYEVENTF_EXTENDEDKEY = 0x0001
KEYEVENTF_KEYUP       = 0x0002
KEYEVENTF_UNICODE     = 0x0004
KEYEVENTF_SCANCODE    = 0x0008

MAPVK_VK_TO_VSC = 0

# msdn.microsoft.com/en-us/library/dd375731
VK_TAB  = 0x09
VK_MENU = 0x12

# C struct definitions

wintypes.ULONG_PTR = wintypes.WPARAM

class MOUSEINPUT(ctypes.Structure):
    _fields_ = (("dx",          wintypes.LONG),
                ("dy",          wintypes.LONG),
                ("mouseData",   wintypes.DWORD),
                ("dwFlags",     wintypes.DWORD),
                ("time",        wintypes.DWORD),
                ("dwExtraInfo", wintypes.ULONG_PTR))

class KEYBDINPUT(ctypes.Structure):
    _fields_ = (("wVk",         wintypes.WORD),
                ("wScan",       wintypes.WORD),
                ("dwFlags",     wintypes.DWORD),
                ("time",        wintypes.DWORD),
                ("dwExtraInfo", wintypes.ULONG_PTR))

    def __init__(self, *args, **kwds):
        super(KEYBDINPUT, self).__init__(*args, **kwds)
        # some programs use the scan code even if KEYEVENTF_SCANCODE
        # isn't set in dwFflags, so attempt to map the correct code.
        if not self.dwFlags & KEYEVENTF_UNICODE:
            self.wScan = user32.MapVirtualKeyExW(self.wVk,
                                                 MAPVK_VK_TO_VSC, 0)

class HARDWAREINPUT(ctypes.Structure):
    _fields_ = (("uMsg",    wintypes.DWORD),
                ("wParamL", wintypes.WORD),
                ("wParamH", wintypes.WORD))

class INPUT(ctypes.Structure):
    class _INPUT(ctypes.Union):
        _fields_ = (("ki", KEYBDINPUT),
                    ("mi", MOUSEINPUT),
                    ("hi", HARDWAREINPUT))
    _anonymous_ = ("_input",)
    _fields_ = (("type",   wintypes.DWORD),
                ("_input", _INPUT))

LPINPUT = ctypes.POINTER(INPUT)

def _check_count(result, func, args):
    if result == 0:
        raise ctypes.WinError(ctypes.get_last_error())
    return args

user32.SendInput.errcheck = _check_count
user32.SendInput.argtypes = (wintypes.UINT, # nInputs
                             LPINPUT,       # pInputs
                             ctypes.c_int)  # cbSize

# Functions

def PressKey(hexKeyCode):
    x = INPUT(type=INPUT_KEYBOARD,
              ki=KEYBDINPUT(wVk=hexKeyCode))
    user32.SendInput(1, ctypes.byref(x), ctypes.sizeof(x))

def ReleaseKey(hexKeyCode):
    x = INPUT(type=INPUT_KEYBOARD,
              ki=KEYBDINPUT(wVk=hexKeyCode,
                            dwFlags=KEYEVENTF_KEYUP))
    user32.SendInput(1, ctypes.byref(x), ctypes.sizeof(x))

def AltTab():
    """Press Alt+Tab and hold Alt key for 2 seconds
    in order to see the overlay.
    """
    PressKey(VK_MENU)   # Alt
    PressKey(VK_TAB)    # Tab
    ReleaseKey(VK_TAB)  # Tab~
    time.sleep(2)
    ReleaseKey(VK_MENU) # Alt~

if __name__ == "__main__":
    AltTab()

hexKeyCode is the virtual keyboard mapping as defined by the Windows API. The list of codes is available on MSDN: Virtual-Key Codes (Windows)

You could make a little Tkinter app:

import Tkinter as tk

def onKeyPress(event):
    text.insert('end', 'You pressed %s\n' % (event.char, ))

root = tk.Tk()
root.geometry('300x200')
text = tk.Text(root, background='black', foreground='white', font=('Comic Sans MS', 12))
text.pack()
root.bind('<KeyPress>', onKeyPress)
root.mainloop()