You don't have to set either of them. PYTHONPATH can be set to point to additional directories with private libraries in them. PYTHONHOME sets the location of default libraries.

Documentation:

PYTHONHOME
Change the location of the standard Python libraries. By default, the libraries are searched in prefix/lib/pythonversion and exec_prefix/lib/pythonversion, where prefix and exec_prefix are installation-dependent directories, both defaulting to /usr/local.

When PYTHONHOME is set to a single directory, its value replaces both prefix and exec_prefix. To specify different values for these, set PYTHONHOME to prefix:exec_prefix.

PYTHONPATH
Augment the default search path for module files. The format is the same as the shell’s PATH: one or more directory pathnames separated by os.pathsep (e.g. colons on Unix or semicolons on Windows). Non-existent directories are silently ignored.

In addition to normal directories, individual PYTHONPATH entries may refer to zipfiles containing pure Python modules (in either source or compiled form). Extension modules cannot be imported from zipfiles.

The default search path is installation dependent, but generally begins with prefix/lib/pythonversion (see PYTHONHOME above). It is always appended to PYTHONPATH.

An additional directory will be inserted in the search path in front of PYTHONPATH as described above under Interface options. The search path can be manipulated from within a Python program as the variable sys.path.

Try appending to PYTHONPATH instead of overwriting it completely.

export PYTHONPATH=$PYTHONPATH:/home/dev/python-files

References:

According to the the Python documentation on PYTHONPATH

Augment the default search path for module files. [...]

The default search path is installation dependent, but generally begins with prefix/lib/pythonversion (see PYTHONHOME above). It is always appended to PYTHONPATH.

meaning that some values exist in PYTHONPATH and the default search path is also only appended.

Additionally, this blog post (Archive.org link) also explains clearly why you need to append to PYTHONPATH and not overwrite it. Scrolling down to the section - Special cases and examining the search path explains it clearly (unfortunately no relative URL to that link so you'll have to scroll). Although the user gives the examples on a mac they are very much relevant to any platform

Typically, the environment variable $PYTHONPATH is empty (try echo $PYTHONPATH). The actual list of folders python searches for libraries can be found with (in python):

import sys
print(sys.path)

This will consist (in search order) of the current directory, any directories in your $PYTHONPATH, and finally the default library directories, set by site.py. The main default locations are (where X.Y is the python version, eg 2.7):

/usr/lib/pythonX.Y (python system libraries, eg re, urllib)
/usr/lib/pythonX.Y/dist-packages (python libraries installed with deb packages)

If you use pip install --user or similar to install libraries as yourself, it will also contain the user library directory:

/home/USERNAME/.local/lib/pythonX.Y/site-packages

You can manipulate the PYTHONPATH by either setting the environment variable before you launch python (PYTHONPATH=$PYTHONPATH:/foo/bar), or by editing sys.path once you've started python (import sys; sys.path = ["/foo/bar"] + sys.path).

However, if you want to play with your own python libraries, a good idea is to create a virtualenv. This is a directory in which you can play around with your own versions of python libraries without any risk of messing up the python libraries used by the system. See How to set up and use a virtual python environment in Ubuntu? for information about creating and using a virtualenv.