You can use selectors for handle I/O multiplexing:

https://docs.python.org/3/library/selectors.html

Try this out:

#! /usr/bin/python3

import sys
import fcntl
import os
import selectors

# set sys.stdin non-blocking
orig_fl = fcntl.fcntl(sys.stdin, fcntl.F_GETFL)
fcntl.fcntl(sys.stdin, fcntl.F_SETFL, orig_fl | os.O_NONBLOCK)

# function to be called when enter is pressed
def got_keyboard_data(stdin):
    print('Keyboard input: {}'.format(stdin.read()))

# register event
m_selector = selectors.DefaultSelector()
m_selector.register(sys.stdin, selectors.EVENT_READ, got_keyboard_data)

while True:
    sys.stdout.write('Type something and hit enter: ')
    sys.stdout.flush()
    for k, mask in m_selector.select():
        callback = k.data
        callback(k.fileobj)

The above code will hold on the line

for k, mask in m_selector.select():

until a registered event occurs, returning a selector_key instance (k) and a mask of monitored events.

In the above example we registered only one event (Enter key press):

m_selector.register(sys.stdin, selectors.EVENT_READ, got_keyboard_data)

The selector key instance is defined as follows:

abstractmethod register(fileobj, events, data=None)

Therefore, the register method sets k.data as our callback function got_keyboard_data, and calls it when the Enter key is pressed:

callback = k.data
callback(k.fileobj)

A more complete example (and hopefully more useful) would be to multiplex stdin data from user with incoming connections from network:

import selectors
import socket
import sys
import os
import fcntl

m_selector = selectors.DefaultSelector()

# set sys.stdin non-blocking
def set_input_nonblocking():
    orig_fl = fcntl.fcntl(sys.stdin, fcntl.F_GETFL)
    fcntl.fcntl(sys.stdin, fcntl.F_SETFL, orig_fl | os.O_NONBLOCK)

def create_socket(port, max_conn):
    server_addr = ('localhost', port)
    server = socket.socket(socket.AF_INET, socket.SOCK_STREAM)
    server.setsockopt(socket.SOL_SOCKET, socket.SO_REUSEADDR, 1)
    server.setblocking(False)
    server.bind(server_addr)
    server.listen(max_conn)
    return server

def read(conn, mask):
    global GO_ON
    client_address = conn.getpeername()
    data = conn.recv(1024)
    print('Got {} from {}'.format(data, client_address))
    if not data:
         GO_ON = False

def accept(sock, mask):
    new_conn, addr = sock.accept()
    new_conn.setblocking(False)
    print('Accepting connection from {}'.format(addr))
    m_selector.register(new_conn, selectors.EVENT_READ, read)

def quit():
    global GO_ON
    print('Exiting...')
    GO_ON = False


def from_keyboard(arg1, arg2):
    line = arg1.read()
    if line == 'quit\n':
        quit()
    else:
        print('User input: {}'.format(line))

GO_ON = True
set_input_nonblocking()

# listen to port 10000, at most 10 connections
server = create_socket(10000, 10)

m_selector.register(server, selectors.EVENT_READ, accept)
m_selector.register(sys.stdin, selectors.EVENT_READ, from_keyboard)

while GO_ON:
    sys.stdout.write('>>> ')
    sys.stdout.flush()
    for k, mask in m_selector.select():
        callback = k.data
        callback(k.fileobj, mask)


# unregister events
m_selector.unregister(sys.stdin)

# close connection
server.shutdown()
server.close()

#  close select
m_selector.close()

You can test using two terminals. first terminal:

$ python3 test.py 
>>> bla

open another terminal and run:

 $ nc localhost 10000
 hey!

back to the first

>>> qwerqwer     

Result (seen on the main terminal):

$ python3 test.py 
>>> bla
User input: bla

>>> Accepting connection from ('127.0.0.1', 39598)
>>> Got b'hey!\n' from ('127.0.0.1', 39598)
>>> qwerqwer     
User input: qwerqwer

>>>