Here is one way in Python/OpenCV. Threshold the image on white. Then apply some morphology to clean it up a bit. Then invert it to make a mask. Then apply the mask to the input. I note that your pills overlap the ring. So this method does not remove the ring.
Input:

import cv2
import numpy as np
# Read image
img = cv2.imread('pills.jpg')
hh, ww = img.shape[:2]
# threshold on white
# Define lower and uppper limits
lower = np.array([200, 200, 200])
upper = np.array([255, 255, 255])
# Create mask to only select black
thresh = cv2.inRange(img, lower, upper)
# apply morphology
kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (20,20))
morph = cv2.morphologyEx(thresh, cv2.MORPH_CLOSE, kernel)
# invert morp image
mask = 255 - morph
# apply mask to image
result = cv2.bitwise_and(img, img, mask=mask)
# save results
cv2.imwrite('pills_thresh.jpg', thresh)
cv2.imwrite('pills_morph.jpg', morph)
cv2.imwrite('pills_mask.jpg', mask)
cv2.imwrite('pills_result.jpg', result)
cv2.imshow('thresh', thresh)
cv2.imshow('morph', morph)
cv2.imshow('mask', mask)
cv2.imshow('result', result)
cv2.waitKey(0)
cv2.destroyAllWindows()
Threshold image:

Morphology cleaned image:

Mask image:

Result:

Here is one way in Python/OpenCV. Threshold the image on white. Then apply some morphology to clean it up a bit. Then invert it to make a mask. Then apply the mask to the input. I note that your pills overlap the ring. So this method does not remove the ring.
Input:

import cv2
import numpy as np
# Read image
img = cv2.imread('pills.jpg')
hh, ww = img.shape[:2]
# threshold on white
# Define lower and uppper limits
lower = np.array([200, 200, 200])
upper = np.array([255, 255, 255])
# Create mask to only select black
thresh = cv2.inRange(img, lower, upper)
# apply morphology
kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (20,20))
morph = cv2.morphologyEx(thresh, cv2.MORPH_CLOSE, kernel)
# invert morp image
mask = 255 - morph
# apply mask to image
result = cv2.bitwise_and(img, img, mask=mask)
# save results
cv2.imwrite('pills_thresh.jpg', thresh)
cv2.imwrite('pills_morph.jpg', morph)
cv2.imwrite('pills_mask.jpg', mask)
cv2.imwrite('pills_result.jpg', result)
cv2.imshow('thresh', thresh)
cv2.imshow('morph', morph)
cv2.imshow('mask', mask)
cv2.imshow('result', result)
cv2.waitKey(0)
cv2.destroyAllWindows()
Threshold image:

Morphology cleaned image:

Mask image:

Result:

Here is another way to do that in Python/OpenCV removing the ring. But it will remove parts of the pills that overlap the ring.
- Read the input
- Threshold on white
- Apply morphology close to remove the center strip
- Get the contours
- Draw the contours as white filled on black background
- Get the convex hull of the white filled contours
- Fit an ellipse to the convex hull
- Print the ellipse shape to make sure it is close to a circle
- Draw the convex hull outline in red on the input to check if fits the white region
- Draw a circle using the average ellipse radii and center as white filled on black background
- Erode the circle a little to avoid leaving a partial white ring
- Combine the inverted morph image and the circle image to make a final mask
- Apply the final mask to the input
- Save the results
import cv2
import numpy as np
# Read image
img = cv2.imread('pills.jpg')
hh, ww = img.shape[:2]
# threshold on white
# Define lower and uppper limits
lower = np.array([200, 200, 200])
upper = np.array([255, 255, 255])
# Create mask to only select black
thresh = cv2.inRange(img, lower, upper)
# apply morphology
kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (20,20))
morph = cv2.morphologyEx(thresh, cv2.MORPH_CLOSE, kernel)
# get contours
contours = cv2.findContours(morph, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_SIMPLE)
contours = contours[0] if len(contours) == 2 else contours[1]
# draw white contours on black background as mask
mask = np.zeros((hh,ww), dtype=np.uint8)
for cntr in contours:
cv2.drawContours(mask, [cntr], 0, (255,255,255), -1)
# get convex hull
points = np.column_stack(np.where(thresh.transpose() > 0))
hullpts = cv2.convexHull(points)
((centx,centy), (width,height), angle) = cv2.fitEllipse(hullpts)
print("center x,y:",centx,centy)
print("diameters:",width,height)
print("orientation angle:",angle)
# draw convex hull on image
hull = img.copy()
cv2.polylines(hull, [hullpts], True, (0,0,255), 1)
# create new circle mask from ellipse
circle = np.zeros((hh,ww), dtype=np.uint8)
cx = int(centx)
cy = int(centy)
radius = (width+height)/4
cv2.circle(circle, (cx,cy), int(radius), 255, -1)
# erode circle a bit to avoid a white ring
kernel = cv2.getStructuringElement(cv2.MORPH_ELLIPSE, (6,6))
circle = cv2.morphologyEx(circle, cv2.MORPH_ERODE, kernel)
# combine inverted morph and circle
mask2 = cv2.bitwise_and(255-morph, 255-morph, mask=circle)
# apply mask to image
result = cv2.bitwise_and(img, img, mask=mask2)
# save results
cv2.imwrite('pills_thresh2.jpg', thresh)
cv2.imwrite('pills_morph2.jpg', morph)
cv2.imwrite('pills_mask2.jpg', mask)
cv2.imwrite('pills_hull2.jpg', hull)
cv2.imwrite('pills_circle.jpg', circle)
cv2.imwrite('pills_result2.jpg', result)
cv2.imshow('thresh', thresh)
cv2.imshow('morph', morph)
cv2.imshow('mask', mask)
cv2.imshow('hull', hull)
cv2.imshow('circle', circle)
cv2.imshow('mask2', mask2)
cv2.imshow('result', result)
cv2.waitKey(0)
cv2.destroyAllWindows()
Threshold image:

Morphology image:

Filled contours image:

Convex hull on input:

Circle image:

Final mask image:

Result:

I solved your problem using the OpenCV's watershed algorithm. You can find the theory and examples of watershed here.
First I selected several points (markers) to dictate where is the object I want to keep, and where is the background. This step is manual, and can vary a lot from image to image. Also, it requires some repetition until you get the desired result. I suggest using a tool to get the pixel coordinates. Then I created an empty integer array of zeros, with the size of the car image. And then I assigned some values (1:background, [255,192,128,64]:car_parts) to pixels at marker positions.
NOTE: When I downloaded your image I had to crop it to get the one with the car. After cropping, the image has size of 400x601. This may not be what the size of the image you have, so the markers will be off.
Afterwards I used the watershed algorithm. The 1st input is your image and 2nd input is the marker image (zero everywhere except at marker positions). The result is shown in the image below.

I set all pixels with value greater than 1 to 255 (the car), and the rest (background) to zero. Then I dilated the obtained image with a 3x3 kernel to avoid losing information on the outline of the car. Finally, I used the dilated image as a mask for the original image, using the cv2.bitwise_and() function, and the result lies in the following image:

Here is my code:
import cv2
import numpy as np
import matplotlib.pyplot as plt
# Load the image
img = cv2.imread("/path/to/image.png", 3)
# Create a blank image of zeros (same dimension as img)
# It should be grayscale (1 color channel)
marker = np.zeros_like(img[:,:,0]).astype(np.int32)
# This step is manual. The goal is to find the points
# which create the result we want. I suggest using a
# tool to get the pixel coordinates.
# Dictate the background and set the markers to 1
marker[204][95] = 1
marker[240][137] = 1
marker[245][444] = 1
marker[260][427] = 1
marker[257][378] = 1
marker[217][466] = 1
# Dictate the area of interest
# I used different values for each part of the car (for visibility)
marker[235][370] = 255 # car body
marker[135][294] = 64 # rooftop
marker[190][454] = 64 # rear light
marker[167][458] = 64 # rear wing
marker[205][103] = 128 # front bumper
# rear bumper
marker[225][456] = 128
marker[224][461] = 128
marker[216][461] = 128
# front wheel
marker[225][189] = 192
marker[240][147] = 192
# rear wheel
marker[258][409] = 192
marker[257][391] = 192
marker[254][421] = 192
# Now we have set the markers, we use the watershed
# algorithm to generate a marked image
marked = cv2.watershed(img, marker)
# Plot this one. If it does what we want, proceed;
# otherwise edit your markers and repeat
plt.imshow(marked, cmap='gray')
plt.show()
# Make the background black, and what we want to keep white
marked[marked == 1] = 0
marked[marked > 1] = 255
# Use a kernel to dilate the image, to not lose any detail on the outline
# I used a kernel of 3x3 pixels
kernel = np.ones((3,3),np.uint8)
dilation = cv2.dilate(marked.astype(np.float32), kernel, iterations = 1)
# Plot again to check whether the dilation is according to our needs
# If not, repeat by using a smaller/bigger kernel, or more/less iterations
plt.imshow(dilation, cmap='gray')
plt.show()
# Now apply the mask we created on the initial image
final_img = cv2.bitwise_and(img, img, mask=dilation.astype(np.uint8))
# cv2.imread reads the image as BGR, but matplotlib uses RGB
# BGR to RGB so we can plot the image with accurate colors
b, g, r = cv2.split(final_img)
final_img = cv2.merge([r, g, b])
# Plot the final result
plt.imshow(final_img)
plt.show()
If you have a lot of images you will probably need to create a tool to annotate the markers graphically, or even an algorithm to find markers automatically.
The problem is that you're subtracting arrays of unsigned 8 bit integers. This operation can overflow.
To demonstrate
>>> import numpy as np
>>> a = np.array([[10,10]],dtype=np.uint8)
>>> b = np.array([[11,11]],dtype=np.uint8)
>>> a - b
array([[255, 255]], dtype=uint8)
Since you're using OpenCV, the simplest way to achieve your goal is to use cv2.absdiff().
>>> cv2.absdiff(a,b)
array([[1, 1]], dtype=uint8)














