Related answer, but if you want to run clean up a user inputting values into a form, here's what you can do:

const numFormatter = new Intl.NumberFormat('en-US', {
  style: "decimal",
  maximumFractionDigits: 2
})

// Good Inputs
parseFloat(numFormatter.format('1234').replace(/,/g,"")) // 1234
parseFloat(numFormatter.format('123').replace(/,/g,"")) // 123

// 3rd decimal place rounds to nearest
parseFloat(numFormatter.format('1234.233').replace(/,/g,"")); // 1234.23
parseFloat(numFormatter.format('1234.239').replace(/,/g,"")); // 1234.24

// Bad Inputs
parseFloat(numFormatter.format('1234.233a').replace(/,/g,"")); // NaN
parseFloat(numFormatter.format('$1234.23').replace(/,/g,"")); // NaN

// Edge Cases
parseFloat(numFormatter.format(true).replace(/,/g,"")) // 1
parseFloat(numFormatter.format(false).replace(/,/g,"")) // 0
parseFloat(numFormatter.format(NaN).replace(/,/g,"")) // NaN

Use the international date local via format. This cleans up any bad inputs, if there is one it returns a string of NaN you can check for. There's no way currently of removing commas as part of the locale (as of 10/12/19), so you can use a regex command to remove commas using replace.

ParseFloat converts the this type definition from string to number

If you use React, this is what your calculate function could look like:

updateCalculationInput = (e) => {
    let value;
    value = numFormatter.format(e.target.value); // 123,456.78 - 3rd decimal rounds to nearest number as expected
    if(value === 'NaN') return; // locale returns string of NaN if fail
    value = value.replace(/,/g, ""); // remove commas
    value = parseFloat(value); // now parse to float should always be clean input

    // Do the actual math and setState calls here
}

function removeLastComma(str) {
   return str.replace(/,(\s+)?$/, '');   
}

you can use reg ex for this

/[,\s]+|[,\s]+/g

var str= "your string here";
//this will be new string after replace
str = str.replace(/[,\s]+|[,\s]+/g, 'your string here');

RegEx Explained and Demo

In this specific case (there is always a single character at the start you want to remove) you'll want:

str.substring(1)

However, if you want to be able to detect if the comma is there and remove it if it is, then something like:

if (str[0] == ',') { 
  str = str.substring(1);
}

s = s.substring(0, s.length - 1);