Hi Ricky,
The selected mode should correspond to the interface you want together with the connections. They are all linked.
In RS-422 mode (which is 4-wire) the 4-wire attribute mist be selected with no short between RX & TX.
In RS-485 mode (which is 2-wire) the 2-wire Auto attribute must be selected with the short between RX & TX.
In RS-422 mode the transmitter is always enabled (single master configuration) in RS-485 the transceiver must (automatically) switch between transmit and receive mode.
RS-422 can be used as a Full-duplex interface i.e. transmit and receive at the same time
RS-485 can only be used in Half-Duplex i.e. either transmit data or receive data.
You mentioned 'protocol'. Where we talked about is only hardware. As we say the first layer, the hardware layer. A communication protocol is 1 or more levels higher and is related to software. e.g. a ModBus protocol.
From the hardware perspective a line is used to transport data. Any data.
A protocol defines the rules how to communicate. Commands, formats, etc. This can be done through any hardware layer. RS-422, RS-485, RS-232, ethernet, smoke, etc.
Terminators:
RS-485 is a very robust interface. It will work also in harsh environments. When I connect two (or more) device together on my workbench I don't care about terminators, twisted pair cable, RS-485 cable, Ground connection,etc. Just using a few fires and it works. If it doesn't I have to keep in mind that I used a sh*t connection.
If we are installing an interface at the customer site it has to work for many years and we want to be sure that it will always work.
So that is why we use the terminators, Daisy chain wiring and good RS-485 cable.
RS-485 (and RS-422) are balanced lines. If you have an electronic background you know what that is.
Balanced lines must be terminated to have a guaranteed energy transport. To be sure that the lines are forced in a idle state fail-safe terminators are use at one side. See attached picture.
Vcc and Gnd are the power supply connection of the RS-485 transceiver.
At the outside it is not always possible to wire it this way. Look in the manual to see if your master has terminitors. If you are not able to create a fail-safe terminator use the next step. A passive terminator as connected to the end of the line.
Kees
Windmill Software
windmill.co.uk › rs485.html
Understanding RS485: Wiring, Connection, Monitoring Software
Ideally an RS485 system consists of a single linear cable (no branches) with 120 ohm resistors connected across the 2 wires at each end of the cable.
Innon
know.innon.com › howtowire-non-optoisolated
How do I wire RS485 devices? - Knowledge Base
When the devices on the RS485 network are all opto-isolated, it is common practice to use a 2 wire twisted pair shielded cable, where the shield is used also as "return path" (ground) and is connected to each device like shown here:
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RS-485 Connection Wires: 2-Wire vs 3-Wire Explained
NI
knowledge.ni.com › KnowledgeArticleDetails
Set Up 2-Wire (Half-Duplex) Communication with RS-485 Port - NI
August 3, 2023 - RS-485 is set up for four-wire communication by default. To connect a 2-wire device, you will need to short the transmit and receive signals together on the RS-485 port. Note that this is necessary to connect RJ45 (8-pin modular jack) ports to RJ50 (10-pin modular jack) ports.
NI
knowledge.ni.com › KnowledgeArticleDetails
Set Up 2-Wire (Half-Duplex) Communication with RS-485 Port
August 3, 2023 - Privacy | Terms of Use | Other Legal Info | National Instruments Corporation. All rights reserved
EKM Support Desk
help.ekmmetering.com › support › solutions › articles › 6000058103-rs485-wiring-how-to-best-practices
RS485 Wiring - How to - Best Practices : EKM Support Desk
May 6, 2026 - Regardless of the communication device, the wiring connections are the same. RS-485 communication is done with 2-wire connections that connect A and B ports on the meter(s) to A and B ports on the communication device.
Control Solutions
csimn.com › CSI_pages › RS-485-FAQ.html
RS-485 FAQ - Control Solutions
The 2 wires being referred to any time you hear “2-wire” are the data lines. Both of them are data. Neither of them is signal ground. RS-485 is a differential signaling method. What this means is that the same data is transmitted on both wires, but in exact opposite polarity.
Go4b
go4b.com › usa › technical-support › product-manuals › t500-hotbus › rs485-wiring-guide.pdf pdf
Proper Wiring for RS-485
RS-485 is designed to be a balanced system. Simply put, this means there are 2 wires, other than ground,
AutoCtrls
autoctrls.com › home › understanding the rs485 2-wire pinout: a comprehensive guide
Understanding the RS485 2-Wire Pinout: A Comprehensive Guide
November 24, 2025 - The RS485 2-Wire Pinout consists of two wires: one for transmitting data (TX) and one for receiving data (RX). These wires are commonly referred to as A and B, with A being the non-inverting line and B being the inverting line.
Advantech
advantech.com › home › support › resources › basics of the rs-485 standard
Basics of the RS-485 Standard - Advantech
August 28, 2018 - An RS-485 network can be configured in two ways: “two-wire” or “four- wire.” In a “two-wire” network the transmitter and receiver of each device are connected to a twisted pair. “Four-wire” networks have one master port with the transmitter connected to each of the “slave” ...