UCLA Health
uclahealth.org › medical-services › surgery › endocrine-surgery › patient-resources › patient-education › endocrine-surgery-encyclopedia › hypothyroidism-secondary
Hypothyroidism Secondary - Endocrine Surgery | UCLA Health
Symptoms vary from mild to severe. The most severe form is called myxedema, which is a medical emergency and can lead to coma and death. Risk factors for secondary hypothyroidism include being over 50 years old, being female, and having a history of pituitary or hypothalamic dysfunction.
Verywell Health
verywellhealth.com › secondary-hypothyroidism-5272471
Secondary Hypothyroidism: Causes, Symptoms, Treatment
October 16, 2025 - Secondary hypothyroidism happens when the pituitary gland does not make enough TSH to stimulate the thyroid, often due to a pituitary tumor. Symptoms include fatigue, dry skin, joint and muscle pain, and weight gain.
Secondary Hypothyroidism..?
What's your MCV, MCH, hemoglobin, prolactin, IGF1?
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June 28, 2022Is this suggestive of secondary hypothyroidism?
This looks suspiciously like central hypothyroidism. Your pituitary gland isn't putting out enough TSH, and so your body isn't producing enough T4.
You need to get all your other pituitary hormones (and the related hormones) checked, in particular prolactin, IGF-1, ACTH and cortisol. ACTH and cortisol are for adrenal insufficiency. If your prolactin is high, that indicates that your hypothalamus is putting out a lot of TRH in order to drive TSH production. As a side effect, prolactin is often moderately elevated.
The problem is that many doctors appear to think that central hypothyroidism means your TSH has to be close to zero. This is not the case. It just has to be "inappropriately low", and with your very low fT4 and symptoms, your TSH is most definitely "inappropriately low".
It is fairly likely that you have deficiencies in other pituitary hormones as well.
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January 27, 2020Anyone have experience with Central (Secondary) Hypothyroidism? I just got my diagnosis.
Yes, I have Central Hypothyroidism after a Pituitary tumor removal. I've had this condition for over 14 1/2 years. When correcting the Central Hypothyroidism, your fT3 and fT4 levels are what should be looked at. In my case, my TSH is non-existent, so it's useless for determining how my thyroid meds are working. With Central Hypothyroidism, your fT3 and fT4 levels must be in the UPPER HALF of the range. Just being in range isn't good enough and you will still be Hypothyroid. If both fT3 and fT4 are low, you need to replace with Synthroid(Levothyroxine), which replaces fT4 and Cytomel(Liothyronine), which replaces fT3. Best Wishes! More on reddit.com
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April 21, 2022Just diagnosed with secondary hypothyroidism..anyone else?
What are your labs? I believe initially I was diagnosed with this, as my TSH was normal, but somewhere along the way that diagnosis got changed.
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February 6, 2023Videos
Video: Hypothyroidism - Video Explanation! | Osmosis | Osmosis
04:26
Hypothyroidism (Underactive Thyroid): Symptoms, Diagnosis & Treatment ...
02:26
Signs of Hypothyroidism | UCLA Endocrine Center - YouTube
03:04
Hypothyroidism: A Diagnostic Approach - YouTube
07:32
Hypothyroidism & Myxedema Coma - Medical-Surgical - Endocrine | ...
05:40
Hypothyroidism and Hashimoto's Thyroiditis: Visual Explanation ...
Merck Manual
merckmanuals.com › professional › endocrine and metabolic disorders › thyroid disorders › hypothyroidism
Hypothyroidism - Endocrine and Metabolic Disorders - Merck Manual Professional Edition
June 5, 2024 - Secondary hypothyroidism is caused by hypothalamic or pituitary disease. Signs and symptoms of primary hypothyroidism are often mild and nonspecific and can include fatigue, cold intolerance, constipation, fluid retention, periorbital edema, and/or impaired mental clarity.
Endocrinologyadvisor
endocrinologyadvisor.com › home › ddi › central hypothyroidism
Central Hypothyroidism - Endocrinology Advisor
August 13, 2025 - Central hypothyroidism occurs when there is a problem with the pituitary gland (secondary) or hypothalamus (tertiary) rather than with the thyroid gland itself. CeH affects approximately 1 in 16,000 to 1 in 100,000 people.2 · In infants and children, central hypothyroidism may be caused by gene mutations or other issues such as2: craniopharyngiomas (benign tumors of the pituitary gland) ... Other symptoms may include low sodium, high cholesterol, heart failure, and QT interval prolongation.
Texas Department of State Health Services
dshs.texas.gov › home › newborn screening program › newborn screening parent resources › secondary hypothyroidism
Secondary Hypothyroidism | Texas DSHS
Children who have hypothyroidism due to a pituitary or hypothalamus gland problem should take thyroid hormone replacement. Sometimes children with secondary hypothyroidism have problems with other endocrine glands, such as the adrenal gland. One of the effects of taking hormone replacement is an increased metabolic rate.
Healthline
healthline.com › health › hypothryroidism › pituitary-hypothyroidism
Pituitary Hypothyroidism: Causes, Symptoms, and Treatment
March 23, 2023 - Secondary hypothyroidism is a rare form of hypothyroidism caused by your pituitary gland underproducing TSH. It makes up · less than 1% of cases of hypothyroidism and can cause symptoms like fatigue, poor cold tolerance, and weight gain.
NCBI
ncbi.nlm.nih.gov › books › NBK519536
Hypothyroidism - StatPearls - NCBI Bookshelf
February 18, 2024 - The less commonly seen secondary or central hypothyroidism occurs when the thyroid gland functions normally; however, hypothyroidism results from the abnormal pituitary gland or hypothalamus function. Untreated hypothyroidism increases morbidity and mortality.
Mayo Clinic
mayoclinic.org › diseases-conditions › hypothyroidism › symptoms-causes › syc-20350284
Hypothyroidism (underactive thyroid) - Symptoms and causes - Mayo Clinic
December 10, 2022 - Understand what happens when your thyroid is underactive and learn about treatment for this condition.
American Academy of Family Physicians
aafp.org › pubs › afp › issues › 2021 › 0515 › p605.html
Hypothyroidism: Diagnosis and Treatment | AAFP
May 15, 2021 - Clinical hypothyroidism occurs ... hypothyroidism can contribute to numerous physiologic and metabolic derangements. Signs and symptoms are nonspecific and can vary in individual presentations (Table 2 and Table 31,3,10). Diagnosis is based on blood levels of decreased FT4, with a corresponding elevated thyrotropin (i.e., TSH) level in primary causes (thyroid source); the TSH level may be normal to low in secondary (pituitary ...
PrimeHealth Denver
primehealthdenver.com › home › education › what is secondary hypothyroidism? diagnosis & treatment
What Is Secondary Hypothyroidism? Diagnosis & Treatment | PrimeHealth Denver
May 31, 2021 - Imagine you’re feeling tired all the time, gaining weight, or dealing with muscle soreness—these symptoms could be linked to a myriad of health issues, not just hypothyroidism. Due to its rarity, secondary hypothyroidism might not even be on the radar initially, leading to a delayed diagnosis.
NHS
nhs.uk › conditions › underactive-thyroid-hypothyroidism
Underactive thyroid (hypothyroidism) - NHS
An underactive thyroid (hypothyroidism) is a common condition where the thyroid gland in your neck does not make enough hormones. This can cause symptoms like tiredness and weight gain.
Better Health Channel
betterhealth.vic.gov.au › health › conditionsandtreatments › thyroid-hypothyroidism
Thyroid - hypothyroidism | Better Health Channel
Primary hypothyroidism means that the thyroid gland itself is diseased, while secondary hypothyroidism is caused by problems with the pituitary gland, the brain structure that supervises the thyroid gland. The most common cause of primary hypothyroidism is the autoimmune condition Hashimoto’s disease. The symptoms of hypothyroidism can be mild, moderate or severe.
Johns Hopkins Medicine
hopkinsmedicine.org › health › conditions-and-diseases › hypothyroidism
Hypothyroidism | Johns Hopkins Medicine
You may be more likely to have hypothyroidism if you: ... Have an iodine deficiency. Your body needs iodine to make thyroid hormone. Symptoms are different for each person. They are often hard to notice and start slowly. They may be mistaken for symptoms of depression.
Merck Manual
merckmanuals.com › home › hormonal and metabolic disorders › thyroid gland disorders › hypothyroidism
Hypothyroidism - Hormonal and Metabolic Disorders - Merck Manual Consumer Version
March 11, 2024 - Secondary hypothyroidism is much rarer than primary. Insufficient thyroid hormones cause body functions to slow. Symptoms are subtle and develop gradually.
MedlinePlus
medlineplus.gov › ency › article › 000353.htm
Hypothyroidism: MedlinePlus Medical Encyclopedia
You develop new symptoms · Myxedema; Adult hypothyroidism; Underactive thyroid; Goiter - hypothyroidism; Thyroiditis - hypothyroidism; Thyroid hormone - hypothyroidism · Thyroid gland removal - discharge · Endocrine glands · Hypothyroidism · Brain-thyroid link · Primary and secondary hypothyroidism ·
Ucsf
ccpd.ucsf.edu › pituitary-disorders › hormonal-conditions › hypothyroidism
Hypothyroidism | California Center for Pituitary Disorders
Thyroid hormone deficiency causes mental retardation in infants, growth delay in children, and myxedema in adults. Symptoms of thyroid hormone insufficiency include cold intolerance, weight gain, memory loss, dry skin, hair loss, brittle nails, constipation, increased sleep demand, and fatigue.
BMJ Best Practice
bestpractice.bmj.com › topics › en-us › 36
Central hypothyroidism - Symptoms, diagnosis and treatment | BMJ Best Practice US
January 17, 2023 - Symptoms of central hypothyroidism are similar to those of primary hypothyroidism (including fatigability, cold intolerance, weight gain, and depression), and may or may not be accompanied by symptoms of hypopituitarism, such as those of hypogonadism (i.e., decreased libido, infertility) and secondary adrenal insufficiency (i.e., weakness, nausea, vomiting).
Paloma Health
palomahealth.com › learn › secondary-hypothyroidism
What Is Secondary Hypothyroidism? | Paloma Health
September 25, 2024 - Hashimoto’s is the most common cause of hypothyroidism in developed countries where iodine is prevalent. In this autoimmune condition, the immune system flags thyroid cells as foreign and begins to attack them. With time, this leads to chronic inflammation, eventual thyroid gland failure, and an inability to produce thyroid hormones. ... In secondary hypothyroidism, the thyroid gland itself is normal and healthy, but there is a problem with the pituitary gland.
Verywell Health
verywellhealth.com › pituitary-hypothyroidism-5272133
Pituitary Hypothyroidism: Causes, Symptoms, Treatment
September 15, 2025 - Symptoms include fatigue, weight gain, constipation, and changes in skin, hair, and nails. Secondary hypothyroidism is treated with medications like synthetic thyroid hormones and sometimes surgery for pituitary tumors.
AMBOSS
amboss.com › us › knowledge › hypothyroidism
Hypothyroidism - Knowledge @ AMBOSS
2 weeks ago - Initially, edema is pretibial, but as the condition progresses it can generalize, resulting in a range of symptoms (see “Clinical features” below). Register or log in , in order to read the full article. ... Woltman sign: a delayed relaxation of the deep tendon reflexes, which is commonly seen in patients with hypothyroidism, but may also be associated with advanced age, pregnancy, and diabetes mellitus. Entrapment syndromes (e.g., carpal tunnel syndrome) ... Abnormal menstrual cycle; (esp. secondary amenorrhea; or menorrhagia)