Since strptime returns a datetime object which has tzinfo attribute, We can simply replace it with desired timezone.

>>> import datetime

>>> date_time_str = '2018-06-29 08:15:27.243860'
>>> date_time_obj = datetime.datetime.strptime(date_time_str, '%Y-%m-%d %H:%M:%S.%f').replace(tzinfo=datetime.timezone.utc)
>>> date_time_obj.tzname()
'UTC'

strptime uses %z to specify a UTC offset in the format of ±HHMM[SS[.ffffff]]. Since minutes are required and your sample input only has hours, you can concatenate '00' to the string before parsing:

datetime.strptime(s + '00', '%Y-%m-%d %H:%M:%S.%f%z')

%z is supported in Python 3.2+:

>>> from datetime import datetime
>>> datetime.strptime('2009/05/13 19:19:30 -0400', '%Y/%m/%d %H:%M:%S %z')
datetime.datetime(2009, 5, 13, 19, 19, 30,
                  tzinfo=datetime.timezone(datetime.timedelta(-1, 72000)))

On earlier versions:

from datetime import datetime

date_str = '2009/05/13 19:19:30 -0400'
naive_date_str, _, offset_str = date_str.rpartition(' ')
naive_dt = datetime.strptime(naive_date_str, '%Y/%m/%d %H:%M:%S')
offset = int(offset_str[-4:-2])*60 + int(offset_str[-2:])
if offset_str[0] == "-":
   offset = -offset
dt = naive_dt.replace(tzinfo=FixedOffset(offset))
print(repr(dt))
# -> datetime.datetime(2009, 5, 13, 19, 19, 30, tzinfo=FixedOffset(-240))
print(dt)
# -> 2009-05-13 19:19:30-04:00

where FixedOffset is a class based on the code example from the docs:

from datetime import timedelta, tzinfo

class FixedOffset(tzinfo):
    """Fixed offset in minutes: `time = utc_time + utc_offset`."""
    def __init__(self, offset):
        self.__offset = timedelta(minutes=offset)
        hours, minutes = divmod(offset, 60)
        #NOTE: the last part is to remind about deprecated POSIX GMT+h timezones
        #  that have the opposite sign in the name;
        #  the corresponding numeric value is not used e.g., no minutes
        self.__name = '<%+03d%02d>%+d' % (hours, minutes, -hours)
    def utcoffset(self, dt=None):
        return self.__offset
    def tzname(self, dt=None):
        return self.__name
    def dst(self, dt=None):
        return timedelta(0)
    def __repr__(self):
        return 'FixedOffset(%d)' % (self.utcoffset().total_seconds() / 60)

In Python 3.7+:

from datetime import datetime

time_str = "2012-07-24T23:14:29-07:00"
dt_aware = datetime.fromisoformat(time_str)
print(dt_aware.isoformat('T'))
# -> 2012-07-24T23:14:29-07:00

In Python 3.2+:

from datetime import datetime

time_str = "2012-07-24T23:14:29-0700"
dt_aware = datetime.strptime(time_str, '%Y-%m-%dT%H:%M:%S%z')
print(dt_aware.isoformat('T'))
# -> 2012-07-24T23:14:29-07:00

Note: Before Python 3.7 this variant didn't support : in the -0700 part (both formats are allowed by rfc 3339). See datetime: add ability to parse RFC 3339 dates and times.

On older Python versions such as Python 2.7, you could parse the utc offset manually:

from datetime import datetime

time_str = "2012-07-24T23:14:29-0700"
# split the utc offset part
naive_time_str, offset_str = time_str[:-5], time_str[-5:]
# parse the naive date/time part
naive_dt = datetime.strptime(naive_time_str, '%Y-%m-%dT%H:%M:%S')
# parse the utc offset
offset = int(offset_str[-4:-2])*60 + int(offset_str[-2:])
if offset_str[0] == "-":
   offset = -offset
dt = naive_dt.replace(tzinfo=FixedOffset(offset))
print(dt.isoformat('T'))

where FixedOffset class is defined here.

The dateutil.parser function will parse that timezone format:

from dateutil.parser import parse

dt = parse('2020-10-23T11:50:19+00:00')
print(dt.date())
print(dt.time())
print(dt.tzinfo)

Result:

2020-10-23
11:50:19
tzutc()

You can combine the separate date, time and tzinfo objects into a datetime, if that's what you need, like this:

dt = datetime.combine(dt.date(), dt.time(), tzinfo=dt.tzinfo)
print(dt)

Result:

2020-10-23 11:50:19+00:00