Mayo Clinic
mayoclinic.org › diseases-conditions › hypothyroidism › symptoms-causes › syc-20350284
Hypothyroidism (underactive thyroid) - Symptoms and causes - Mayo Clinic
December 10, 2022 - Understand what happens when your thyroid is underactive and learn about treatment for this condition.
NCBI
ncbi.nlm.nih.gov › books › NBK536970
Subclinical Hypothyroidism - StatPearls - NCBI Bookshelf
February 15, 2024 - In the Thyroid Hormone Replacement for Untreated older adults with subclinical hypothyroidism—a randomized placebo-controlled Trial (TRUST), a double-blinded, randomized, placebo-controlled trial, 737 adults who were aged 65 or older above with subclinical hypothyroidism (TSH between 4.60 and 19.99 mIU/L and free T4 within the reference range) were included. A total of 368 participants received low-dose levothyroxine of 50 mcg daily, except in patients with body weight less than 50 kg or a history of coronary artery disease. After 1 year, no difference was noted in the treatment and placebo groups for the hypothyroid symptoms scale and tiredness score.
Videos
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Subclinical Hypothyroidism
You’re going to get a lot of bad advice on this sub. But yes, retesting in a month or two is good medical advice before starting a life long medication that may or may not help with your symptoms. Hypothyroid symptoms look like a lot of other disorders. Don’t go doctor shopping because your first one didn’t push pills on you after one borderline TSH test. More on reddit.com
How many people got treated with subclinical hypothyroidism?
Levothyroxine resolved my anger, mental confusion, and poor memory. TSH of 5.22 at the time of diagnosis. More on reddit.com
Subclinical hypothyroidism overdiagnosis and treatment
Subclinical hypothyroidism is a difficult topic because is has two categories of symptoms that can occur: Symptoms that can be easily and precisely measured (female infertility, miscarriage, deterioration of cholesterol) and symptoms that are non-specific and not easily measured (anhedonia, fatigue, depression, hair loss, anxiety). Infertility and miscarriages are easily measured and as a consequence most women will get treated if their TSH is above 2.5, certainly if it's above 5. On the other hand, fatigue, depression and anxiety are common, very non-specific and hard to measure objectively. What's more, levothyroxine tends to have a narrow therapeutic index (in most patients, not in all) and if you overdose the patient by a few mcgs she may be just as or even more anxious and fatigued (while mild overdoses on the other hand do not increase the risk of miscarriage, infertility or bad cholesterol), and patient A will do fine at a TSH level that may be too high for patient B but too low for patient C. This makes for very messy and contradictory clinical research and vague guidelines (much less so on the matter of pregnant women, of course). As a consequence, the same doctor who aggressively treats a woman for a TSH of 2.6 if she wants to get pregnant may scoff at the idea of treating someone with a TSH of 8 despite the latter's complaints that she can barely get out of bed and that half her eyebrows have fallen out. From the patients' perspective, this is very unsatisfactory and makes no sense. There's no reason to assume that hard-to-measure symptoms only occur at much higher TSH levels than easy-to-measure symptoms. More practically, many endos take an unexplained elevation of LDL cholesterol and the elevation of TPO/TG antibodies as an argument for treatment, as both make it much more likely that high-in-range or mildly elevated TSH indicates actual thyroid dysfunction. On a side note, the symptoms of iron deficiency (with or without anemia) broadly overlap with the symptoms of thyroid dysfunction, and according to newer studies, iron deficiency affects approximately 20-40% of the pre-menopausal female population, so it may be useful to give a patient complaining of non-specific symptoms iron for a few months unless their ferritin is actually high. More on reddit.com
Subclinical hypothyroidism for dummies
I was hit with a subclinical hypothyroidism diagnosis last year after one blood test where my TSH was 5.8. They prescribed medication and asked me to come back in for a more comprehensive blood test, but they cancelled on me and life happened, so when I saw my new PCP this year, she ran the full blood work. My TSH was down to 4.95, but the TPO antibodies came back positive/high, so my PCP diagnosed me with Hashimoto's and recommend I start a low dose of Levothyroxine because there is no cure. I've been taking 25mcg Levo for about 10 weeks. I did the follow up blood work about a week and a half ago. My TSH is down to 3.03 now. There are a few highlights from my experience I wanted to share: The symptoms are so gradual, I had no idea I was definitely experiencing them and had been for probably two years. I was taking more naps to get through the day, I couldn't eat anything without feeling full, slightly fluffier, more prone to mild depression, mild hair loss, etc. About a week ago, I noticed my energy levels are back to probably 85% of what they were before (along with the other symptoms being generally back to normal as well) and I feel more like myself again. I didn't realize how off I was until getting back to generally how I felt before. I too did a deep dive of the hypothyroidism / hashimotos subs and it is a doom spiral. I obviously can't say what your experience will be - or hell, even predict my own, but something that helped me when I first got the diagnosis was a random comment that said something like, "The majority of the people posting/commenting are the people having problems. I wanted to share my experience - I live a normal life." Tracking my symptoms alongside taking the medication has helped me feel more in control. My doctor is great, but it is really helpful to be able to say, "X started on Friday." Breathe, step away from Google, and be kind to yourself during this time. Good luck! More on reddit.com
Women's Health Network
womenshealthnetwork.com › home › thyroid health › resolving subclinical hypothyroidism symptoms
Subclinical Hypothyroidism Symptoms - Women's Health Network
October 21, 2025 - Fatigue, weight gain, hair loss, skin changes — do any of these symptoms sound familiar? Maybe something feels “off” in your body, yet your healthcare practitioner said that your thyroid levels are fine and everything is functioning normally. How can both things be true? Subclinical hypothyroidism refers to abnormally low thyroid function.
Don't Forget the Bubbles
dontforgetthebubbles.com › home › view all › subclinical hypothyroidism
Subclinical hypothyroidism - Don't Forget the Bubbles
August 9, 2023 - The decision to treat subclinical hypothyroidism in children remains a matter of debate. Management should take into account TSH level and the cause of thyroid dysfunction. Children with TSH >10 ulU/L should be treated whatever the cause, while children with TSH between 5-10 ulUL are treated on an individual basis. Treatment should be recommended in children with a goitre, anti-thyroid autoantibodies and hypothyroid signs or symptoms.
American Academy of Family Physicians
aafp.org › pubs › afp › issues › 2021 › 0515 › p605.html
Hypothyroidism: Diagnosis and Treatment | AAFP
May 15, 2021 - Clinical hypothyroidism affects one in 300 people in the United States, with a higher prevalence among female and older patients. Symptoms range from minimal to life-threatening (myxedema coma); more common symptoms include cold intolerance, fatigue, weight gain, dry skin, constipation, and voice changes.
American Academy of Family Physicians
aafp.org › pubs › afp › issues › 1998 › 0215 › p776.html
Subclinical Hypothyroidism: Deciding When to Treat | AAFP
February 15, 1998 - Dry skin, cold intolerance and easy fatigability were significantly more common in the patients with raised TSH levels, and these symptoms improved after treatment with thyroid hormone. In another study11 of 69 female patients with subclinical hypothyroidism, a clinical index based on symptoms and physical signs was shown to be more abnormal in patients with higher TSH levels, even though all patients had normal serum levels of T4 and free T4.
Gdatf
gdatf.org › home › bulletins › other topics › diagnosis and treatment of subclinical hypothyroidism
Diagnosis and Treatment of Subclinical Hypothyroidism | Graves' Disease and Thyroid Foundation
August 18, 2021 - One may present with mild non-specific symptoms of hypothyroidism, such as fatigue, constipation and depression. A mild thyroid gland enlargement or goiter may be seen. In some studies treatment with thyroid hormone was associated with a significant decrease in goiter in cases of subclinical ...
Merck Manual
merckmanuals.com › professional › endocrine and metabolic disorders › thyroid disorders › hypothyroidism
Hypothyroidism - Endocrine and Metabolic Disorders - Merck Manual Professional Edition
June 5, 2024 - Signs and symptoms of primary hypothyroidism are often mild and nonspecific and can include fatigue, cold intolerance, constipation, fluid retention, periorbital edema, and/or impaired mental clarity. Subclinical hypothyroidism (minimal or no symptoms and an elevated serum level of thyroid-stimulating hormone [TSH]) and normal free thyroxine [T4]) is common.
UpToDate
uptodate.com › contents › subclinical-hypothyroidism-in-nonpregnant-adults
Subclinical hypothyroidism in nonpregnant adults
UpToDate, the evidence-based clinical decision support resource from Wolters Kluwer, is trusted at the point of care by clinicians worldwide.
WebMD
webmd.com › women's health › reference
Hypothyroidism (Underactive Thyroid): Symptoms, Causes, Tests, Treatments
January 13, 2025 - About 3%-20% of people may develop subclinical hypothyroidism. You may be more likely to develop if you’re a woman or person assigned female at birth (AFAB), over 60, or have type 2 diabetes. You may not have symptoms and may not need treatment, but your doctor will want to monitor your thyroid ...
Mount Sinai
mountsinai.org › health-library › report › hypothyroidism
Hypothyroidism Information | Mount Sinai - New York
The prevalence of overt hypothyroidism in the general population varies between 0.3% and 3.7% in the United States. Many more people have mildly underactive thyroid glands (subclinical hypothyroidism). ... In older patients symptoms can be only fatigue, weakness, memory loss, or chest pain.
Patient.info
patient.info › doctor › endocrine-disorders › subclinical-hypothyroidism
Subclinical Hypothyroidism: Causes and Treatment | Doctor
June 28, 2024 - In the elderly a diagnosis of hypothyroidism may be delayed by wrongly attributing the symptoms of, for example, fatigue and constipation to ageing. Clinical manifestations can be explained by assuming that a low T4 level, although inside the normal range, may represent a significant decrease from their previous normal and is therefore low for this particular patient. Some studies have suggested that if symptoms are present in subclinical hypothyroidism then treatment with thyroxine will lead to resolution.
Thyroid UK -
thyroiduk.org › home › if you are hypothyroid › about hypothyroidism › subclinical hypothyroidism
Subclinical Hypothyroidism - Thyroid UK
March 12, 2025 - Subclinical hypothyroidism can be asymptomatic making diagnosis problematic; however, some patients may present with symptoms that would indicate overt hypothyroidism, the main ones being:9,10,11,12,13