It's just a matter of regional preferences.

No hay de qué might be a bit more formal in some contexts, but they mean exactly the same.

Answer from Diego Mijelshon on Stack Exchange
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Reddit
reddit.com › r/spanish › do spanish speakers think of "de nada" literally?
r/Spanish on Reddit: Do Spanish speakers think of "de nada" literally?
July 10, 2013 -

I've been wondering this for a while, “de nada” literally means “of nothing”, but in the mind of a Spanish speaker, is that “of nothing” really how they feel?

Top answer
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I agree with chclau, that it is an established expression and we give no thought so much to the idea of "nothing." A good comparison I think is the English "You're welcome" For many Spanish speakers who are students of English, the literal translation of "You're welcome" is strange. In certain context, not so much. For example, "Thanks for inviting me!" -"you're welcome". But what about "Thanks for letting me know about the practice being canceled" "You're welcome!". I am welcome to what? To receive news about something being canceled? It seems strange in translation, and yet I think English speakers give little thought to the literal meaning of welcome. A simple nuance, here in Spain we use "nada" very often, sometimes in place of "de nada", but also if you bump in to someone and say excuse me. For example: "Gracias por el regalo" "Nada, es un gusto" or When you bump into someone, "Uy, perdón!" "Nada." This second phrase perhaps comes really from "No pasa nada." Nevertheless, we use all of the expressions quite in a natural way without much thought to the meaning of "nada", and yet it still, at times, does have this connotation of "It's nothing". Also, think about the expression English "Not at all." "Thanks for helping me with my homework" "Not at all!"
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To answer your question, sometimes it can literally mean "it was nothing", especially if the person feels that it really did not require much effort. At the same time it could also just be said as a habitual phrase. Think if it in the sense that it would be similar to someone in English saying "your welcome". Sometimes they really mean it, and other times, it's just a habitual phrase that you respond after hearing "thank you". Or if you say "thank you" and the person responds "my pleasure", there's a good chance it really was a pleasure for that person to help you. There are numerous Spanish ways to say "thank you" in Spanish, besides what's mentioned in the other comments. "Por favor" is one that comes to mind, especially in Argentina. For example "Gracias por llevarme a la oficina", the response would be simply "por favor" which implies something like "please, it was nothing". "No fue nada", literally "it was nothing", is another option. "¿De que?", translated as "for what? would be another. "No hay porque", "there is no reason" (to say thank you). "Como no", "of course" "Fue un gusto (placer), "it was a pleasure" which can also be said without incluiding "fue" so it would be "un gusto (placer)"
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Spanish and Go
spanishandgo.com › learn › 15-different-ways-to-say-youre-welcome
Don’t Say “De Nada” [15 Ways to Say You’re Welcome in Spanish] - Spanish and Go
When someone helps you with something and then you say “Oh, gracias”, the other person can say “no es nada”. This is also very casual. When one says “muchas gracias por tu ayuda”, you can respond with “oh, está bien”. This is a very easy and simple way of saying you’re welcome in Spanish. You can also say no se preocupe, for a more formal setting which means “no worries” or “don’t worry”.
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DeepL
deepl.com › en › translator › q › es › de+nada › en › you're+welcome › cdfd4b49
de nada - translated from Spanish to English
Deliver accurate, enterprise-grade translations with pro features like Glossaries, Rules, Clarify and more.
Discussions

traducción - What is the difference between "De nada" and "No hay de qué"? - Spanish Language Stack Exchange
I am learning Spanish and ran across "De nada" and "No hay de qué". Both mean "You're welcome". What's the difference? More on spanish.stackexchange.com
🌐 spanish.stackexchange.com
February 15, 2012
modismos - Why is "De nada" used as a response to "Gracias"? - Spanish Language Stack Exchange
In Spanish, the term "de nada" means "[something] of little importance or value". More on spanish.stackexchange.com
🌐 spanish.stackexchange.com
August 7, 2012
Do Spanish speakers think of "de nada" literally?
I agree with chclau, that it is an established expression and we give no thought so much to the idea of "nothing." A good comparison I think is the English "You're welcome" For many Spanish speakers who are students of English, the literal translation of "You're welcome" is strange. In certain context, not so much. For example, "Thanks for inviting me!" -"you're welcome". But what about "Thanks for letting me know about the practice being canceled" "You're welcome!". I am welcome to what? To receive news about something being canceled? It seems strange in translation, and yet I think English speakers give little thought to the literal meaning of welcome. A simple nuance, here in Spain we use "nada" very often, sometimes in place of "de nada", but also if you bump in to someone and say excuse me. For example: "Gracias por el regalo" "Nada, es un gusto" or When you bump into someone, "Uy, perdón!" "Nada." This second phrase perhaps comes really from "No pasa nada." Nevertheless, we use all of the expressions quite in a natural way without much thought to the meaning of "nada", and yet it still, at times, does have this connotation of "It's nothing". Also, think about the expression English "Not at all." "Thanks for helping me with my homework" "Not at all!" More on reddit.com
🌐 r/Spanish
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July 10, 2013
If ‘De Nada’ directly translates to ‘Of Nothing’, how would you literally say ‘You’re Welcome’?
The problem is when a person literally translates, for you need to understand the intent. De nada becomes roughly it's nothing, and your welcome could be con gusto (with pleasure). The intent is what is important. More on reddit.com
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June 23, 2024
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SpanishDictionary.com
spanishdict.com › spanishdictionary.com › translate › de nada
De nada | Spanish to English Translation - SpanishDictionary.com
Gracias por ayudarme. - De nada. Tú hubieras hecho lo mismo por mí.Thank you for helping me. - Don't mention it.
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BaseLang
baselang.com › home › you’re welcome in spanish: 15 unique expressions for any situation
You’re Welcome in Spanish: Unique expressions for any situation
April 10, 2025 - You probably already know the standard Spanish expression for you’re welcome, but let’s look a bit closer at the actual Spanish de nada meaning. Nada translates directly as nothing, so the literal translation of de nada is of nothing.
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Dictionary.com
dictionary.com › browse › de-nada
DE NADA Definition & Meaning | Dictionary.com
December 5, 2025 - First recorded in 1910–15; from Spanish: literally, “of nothing;” de ( def. ), nada ( def.
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Quora
quora.com › In-Spanish-what-is-the-difference-between-De-Nada-and-No-problema
In Spanish, what is the difference between 'De Nada' and 'No problema'? - Quora
Answer (1 of 17): “De nada” is used when someone says “gracias/thank you”. It has the sense of “you’re welcome”. It is used in everyday speech with other people with whom you interact.
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Quora
quora.com › What-does-de-nada-mean-Is-this-the-standard-response-to-gracias
What does 'de nada' mean? Is this the standard response to 'gracias'? - Quora
Answer (1 of 11): De nada means “you’re welcome”. Other ways to say, “de nada” could be “no es pasa nada”, which means “it was nothing” or pretty much “you’re welcome”. You would use that when referencing something you’ve ...
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WordHippo
wordhippo.com › what-is › the-meaning-of › spanish-word-de_nada.html
What does "de nada" mean in Spanish?
English words for de nada include You're welcome!, you are welcome, you’re welcome, your welcome, you welcome, it's my pleasure and of nothing. Find more Spanish words at wordhippo.com!
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PROMT.One
online-translator.com › translation › spanish-english › nada de nada
"nada de nada" in English | Spanish to English Translation - PROMT.One
Translate "nada de nada" from Spanish to English, nothing at all, . See word usage in contexts, conjugation and declension.
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Quora
quora.com › How-do-you-say-de-nada-in-English
How to say 'de nada' in English - Quora
Answer (1 of 7): De nada is the answer to thank you in Spanish. In English, the most common way to say that would be “You’re welcome!” However, there are other ways to express this idea: No problem!
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Spring Languages
springlanguages.com › home › learn spanish › 5 different ways to say you’re welcome in spanish: stop saying de nada in spanish (+ audio)
You're Welcome in Spanish: 5 Alternatives of Saying De nada
You’re welcome in Spanish is ‘de nada‘. This phrase can be used to politely acknowledge someone for expressing their gratitude.
Published   July 16, 2024
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Pinterest
pinterest.com › pin › de-nada-meaning-what-does-de-nada-mean--612067405632046254
"De Nada" Meaning, Origin and Examples • 7ESL
July 8, 2023 - Discover the meaning and origins of "de nada," a key Spanish phrase, and learn how to use it effectively in various contexts to enhance your Spanish communication skills.
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YouTube
youtube.com › shorts › Y5qqcO8aT_k
Stop saying "DE NADA" every time | Learn Spanish - YouTube
Stop saying "DE NADA" every time | Learn Spanish
Published   September 4, 2025
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AmazingTalker®
en.amazingtalker.com › home › not just de nada: 20 ways to say you’re welcome in spanish
Not Just De Nada: 20 Ways to Say You're Welcome in Spanish
October 9, 2024 - How to say You're Welcome in Spanish: 1. De nada is most common, meaning It's nothing. 2. Por nada: for nothing. 3. Con gusto: happy to help